The digital economy uses its own digital information advantages to reduce the intensity of energy consumption brought by economic growth. Intelligent manufacturing achieves cost reduction and efficiency through the integration of manufacturing and intelligence as well as digitalization and information technology. The two have become a new engine for sustainable economic development at present, and they can promote and influence each other. However, there is a lack of research on the relationship between them. In this regard, this study aims to build a coupling coordination model of digital economy and intelligent manufacturing and to make an empirical analysis using the data of Chinese provincial administrative regions in order to provide a theoretical reference for promoting sustainable economic development. The research finds that (1) the digital economy and intelligent manufacturing are mainly cross-coupled from four aspects: infrastructure, technological innovation, product optimization and organizational change. The development level and speed of the former are significantly higher than those of the latter, and the gap does not decrease with time. The two have a strong correlation, but there is no high-quality coupling coordination. (2) The main obstacle factors to the digital economy lie in the imperfect supporting facilities, the short board of technological innovation and the lack of technological application capacity. Intelligent manufacturing lacks intelligent application and technological innovation. (3) Influencing factors such as opening to the outside world, economic development, high-level talent input, industrial structure and innovation emphasis have different effects on their coupling and coordinated development in different regions. (4) The spatial correlation test shows that the coupling coordination degree of each region is spatially positively correlated. This research helps to promote the coupling and coordinated development of the digital economy and intelligent manufacturing.