Corpus Callosotomy for Intractable Epilepsy in Children

Raffel, Corey; Kongelbeck, S. Redick; Snead, O. Carter

doi:10.1159/000120680

Cited by 10 publications

(2 citation statements)

References 16 publications

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“…The patients that appear to benefit most from this procedure are those with a predominance of drop attacks [3]. The benefit observed in other seizure types varies depending on the reported series [4, 5, 6], however these have not been studied in a controlled, prospective fashion. The literature on corpus callosotomy is comprised largely of retrospective series [3].…”

Section: Introductionmentioning

confidence: 99%

“…Although Dandy initially reported no adverse effects from this procedure, complete sectioning was eventually noted to be associated with a substantial risk of disconnection syndrome and speech disturbances [2, 4]. The advent of partial callosotomy was an attempt to obtain the surgical benefits of seizure control without an increased risk of undesired side-effects.…”

Section: Introductionmentioning

confidence: 99%

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Image-Guided, Frameless Stereotactic Sectioning of the Corpus callosum in Children with Intractable Epilepsy

et al. 2001

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Corpus callosotomy is an effective neurosurgical procedure for children with intractable atonic or drop attack seizures. While this procedure has not changed significantly over the past three decades, some technical issues remain to be resolved. These include the intraoperative determination of the extent of the callosotomy, the need to stage the procedure, as well as side of approach of craniotomy. We report our 8-year experience with corpus callosotomy using a frameless stereotactic image-guided system (ISG Viewing Wand^®). Seventeen children with atonic seizures underwent sectioning of the corpus callosum. The mean patient age was 10.5 years. Six children underwent complete callosotomy while 11 underwent resection of the anterior two-thirds. MRI 3D reconstruction of the sagittal sinus and draining cerebral veins was undertaken in all cases. The side of the craniotomy was determined on the basis of favorability of the draining veins with respect to the extent of the callosotomy. The extent of the callosotomy was determined by intraoperative feedback using the ISG Viewing Wand^®. Nine of 11 patients in the partial callosotomy group and 4 of 6 patients in the complete callosotomy group showed significant improvement in atonic seizures. We conclude that the use of frameless stereotaxy can function as an important adjunct in the planning and conduction of successful sectioning of the corpus callosum in children with intractable seizures.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%