Corpus callosotomy in pediatric patients with non-lesional epileptic encephalopathy with electrical status epilepticus during sleep

Yokosako, Suguru; Muraoka, Norihiro; Watanabe, S.; Kosugi, Kenzo; Takayama, Yutaro; Iijima, Keiya; Kimura, Yoshihiko; Kaneko, Yu; Sumitomo, Noriko; Saito, Takashi; Nakagawa, Eiji; Iwasaki, Masaki

doi:10.1016/j.ebr.2021.100463

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…After surgery, one patient showed complete ESES resolution and IQ improvement, while in the other two cases, EEG paroxysmal abnormalities were lateralized to one hemisphere and the SWI decreased with moderate development and seizure improvement. In these last two cases, from 6 months after surgery, the SWI increased again, but without developmental regression [147].…”

Section: Neurosurgical Treatmentmentioning

confidence: 74%

Continuous Spike–Waves during Slow Sleep Today: An Update

Posar,

Visconti

2024

Children

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In the context of childhood epilepsy, the concept of continuous spike–waves during slow sleep (CSWS) includes several childhood-onset heterogeneous conditions that share electroencephalograms (EEGs) characterized by a high frequency of paroxysmal abnormalities during sleep, which have negative effects on the cognitive development and behavior of the child. These negative effects may have the characteristics of a clear regression or of a slowdown in development. Seizures are very often present, but not constantly. The above makes it clear why CSWS have been included in epileptic encephalopathies, in which, by definition, frequent EEG paroxysmal abnormalities have an unfavorable impact on cognitive functions, including socio-communicative skills, causing autistic features, even regardless of the presence of clinically overt seizures. Although several decades have passed since the original descriptions of the electroclinical condition of CSWS, there are still many areas that are little-known and deserve to be further studied, including the EEG diagnostic criteria, the most effective electrophysiological parameter for monitoring the role of the thalamus in CSWS pathogenesis, its long-term evolution, the nosographic location of Landau–Kleffner syndrome, standardized neuropsychological and behavioral assessments, and pharmacological and non-pharmacological therapies.

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Section: Neurosurgical Treatmentmentioning

confidence: 74%

Continuous Spike–Waves during Slow Sleep Today: An Update

Posar,

Visconti

2024

Children

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“…Callosotomy, which has been used since the 1940s, is an effective palliative treatment of multifocal drug-resistant epilepsy with secondarily generalized seizures. The operation thus contributes to limiting developmental regression, which is a complication of frequent epileptic seizures [67]. Callosotomy is a good form of treatment for diseases such as early infantile epileptic encephalopathy [67].…”

Section: Ethosuximidementioning

confidence: 99%

“…The operation thus contributes to limiting developmental regression, which is a complication of frequent epileptic seizures [67]. Callosotomy is a good form of treatment for diseases such as early infantile epileptic encephalopathy [67]. Traditionally, callosotomy assumes craniotomy, but in recent years, a trend has been observed to use neuroablative techniques to reduce the invasiveness of the procedure [66].…”

Section: Ethosuximidementioning

confidence: 99%

Epilepsy diagnosis and treatment in children – new hopes and challenges – literature review

Urbańska,

Leśniewski,

Welian-Polus

et al. 2024

J Pre Clin Clin Res.

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Introduction andObjective. Epilepsy is one of the most commonly diagnosed neurological aberrations. Epileptic seizures are the main symptoms of the condition. Reducing the seizures is the main objective of the treatment. The aim of the review is to summarise current knowledge on diagnosis and various treatment methods of epilepsy among children. Review Methods. Scientific publications in PubMed, Google Scholar, Wiley Library, Web of Science, Clinicaltrials.gov, and NCBI databases were searched for the review. More than 93% of the articles are less than eight years old. After an initial assessment of articles, meta-analyses and reviews on epilepsy, concerning the pharmacological, surgical, and gene therapy of epilepsy, were selected. Publications were analyzed using a non-systematic review method to create a brief synthesis of the information. Brief description of the state of knowledge. Diagnosis of epilepsy consists of subjective and objective examination of the patient and performing electroencephalography. Additional procedures, such as neuroimaging of the central nervous system, genetic testing, metabolic and immunological tests, may expand the diagnostic stage. Pharmacological methods prove that early initiation of treatment reduces the risk of relapse. First-line pharmacological treatment consists of carbamazepine, valproic acid, oxcarbazepine, and phenytoin. If epilepsy proves to be drug resistant, surgery is an alternative to pharmacotherapy. Invasive treatment consists of resection, separation and neurostimulation. Current knowledge also proves that there is relevant comorbidity among paediatric patients with epilepsy. Summary. The review emphasizes the development of currently used diagnostic methods, therapeutic options, and importance of further research.

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“…Jointly provided by AANSMethods:Results:A total of 184 acute complications were reported in 50 patients (16.8%) and included: wound infection (6), CSF leak (3), malpositioned catheters(18), intracranial hemorrhages(12), transient neurological deficits (80), permanent neurological deficits (24), symptomatic perilesional edema (27), hydrocephalus(12), and death (2). The incidence of complications for low-, medium-, and high-volume centers was 30.0%, 23.2%, and 11.9%, respectively.Conclusions:Our results suggest that SLA is an effective and generally safe treatment option for pediatric patients, although not without risks.…”

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confidence: 99%

46th Annual Meeting The American Society of Pediatric Neurosurgeons

2023

Journal of Neurosurgery: Pediatrics

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Institutions:(1) Divisions of Neurosurgery, (2) Nephrology and (3) Neonatology, (4) and the Children's Mercy Bioethics Center4 Children's Mercy Kansas City Kansas City, MO All authors have no relevant disclosures. Introduction:Informed consent is a pillar of modern bioethics and is supported by numerous ethical principles, including beneficence, respect for persons and personal autonomy. It is also now a legal requirement for most research and medical care. Its elements include that the patient understands the risks/benefits, that "relevant" information has been disclosed to the patient and that the patient has the ability to make a voluntary decision to proceed. Methods:The advent of maternal-fetal medicine has presented unique challenges, starting with the notion of two patients. Furthermore, much of the care offered is at the leading edge of innovation. The impact on informed consent is broad, including uneven distribution of risks, tangible benefit for one patient only, fetal benefit being highest in lethal conditions, the fetus cannot consent and has poorly defined rights (up until delivery) and the father's rights remain unclear. Results:The process of fetal repair of myelomeningocele has passed through the stages of innovation/experiment, research and ultimately to "standard of care" in <25 years. As a non-lethal condition, the risk/benefit approach is much harder to define, particularly as the risks can evolve with the growth of the procedure. It is proposed that the development of the procedures must be based on the hope of reducing disability, with consent being based on the principles of autonomy and beneficence for the mother, but on the beneficence principle only for the baby. Conclusion:An example of a less than ideal informed consent will be presented, and the historical lessons learned from the development of caesarian section will also be reviewed.

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Corpus callosotomy in pediatric patients with non-lesional epileptic encephalopathy with electrical status epilepticus during sleep

Cited by 7 publications

References 23 publications

Continuous Spike–Waves during Slow Sleep Today: An Update

Continuous Spike–Waves during Slow Sleep Today: An Update

Epilepsy diagnosis and treatment in children – new hopes and challenges – literature review

46th Annual Meeting The American Society of Pediatric Neurosurgeons

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