Corpus callosum areas in first-episode patients with bipolar disorder

Abstract

The findings suggest that CC morphology may be associated with the pathophysiology of bipolar disorder.

Corpus callosum area in patients with bipolar disorder with and without psychotic features: an international multicentre study

“…Other groups have proposed that the CC is more susceptible to aging in patients with BD. [6][7][8][9]11 Here, in a relatively large sample, we found a positive association between the CC rostral area and illness duration, but only in the BD subgroup with a positive history of psychosis, adjusted for TBV. This correlation was absent in other CC regions.…”

“…[5][6][7][8][9]11 As the CC follows a topographical organ ization, 4 reductions of the posterior areas suggest that BD may be associated with decreased interhemispheric connectivity between homologous regions wired through the posterior callosum (i.e., parietal, temporal and occipital cortices). 36 Interestingly, a growing number of diffusion MRI studies have independently reported microstructural CC alterations in patients with BD, [1][2][3]27,37 suggesting that callosal abnormalities are identifiable both at a macrostructural and microstructural level in these patients.…”

“…Reduced posterior CC area is the most commonly reported difference between patients with BD and healthy controls. [5][6][7][8][9][10][11] However, several studies have also reported reduced areas of the anterior CC in patients with BD, 7,8,10,12,13 while others have reported no such regional difference. [14][15][16][17] These heterogeneous results may be partly explained by the phenotypic variability of patients with BD, such as the proportion of patients with psychotic features or mean illness duration, across studies.…”

Reduced posterior corpus callosum area in suicidal and non-suicidal patients with bipolar disorder

“…A structural study on bipolar I patients in their first episode of mania (or in a mixed state) showed that these patients have smaller total areas of the posterior body and isthmus regions compared with healthy controls and that mania is inversely correlated with the area of those regions (Atmaca et al, 2007). Other structural studies have also shown that there are significant decreases in the total area of the genu, posterior body and isthmus regions in BD patients compared with healthy controls (Coffman et al, 1990;Brambilla et al, 2003).…”

Staging bipolar disorder: Clinical framework, biomarkers and interventions

“…Corpus callosum takodje može biti izmenjem u ranim fazama BAP. Studije na različitim populacijama obolelih od BAP (prva epizoda bolesti, adolescentni, odrasli sa hronič-nim oblikom bolesti) [64][65][66] nalaze izmene bele mase corpus-a callosum-a , što može biti potencijalni indikator izmenjene mijelinizacije i posledično narušene interhemisferične komunikacije kod BAP [66] .…”