Corpus Callosum Integrity Relates to Improvement of Upper-Extremity Function Following Intensive Rehabilitation in Children With Unilateral Spastic Cerebral Palsy

Robert, Maxime; Gutterman, Jennifer; Ferre, Claudio L; Chin, Karen; Brandão, Marina de Brito; Gordon, Andrew; Friel, Kathleen M.

doi:10.1177/15459683211011220

Cited by 10 publications

(10 citation statements)

References 60 publications

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“…This is further supported by studies on other pediatric populations which have shown that damage to certain neurological networks is associated with motor planning deficits in children with tumors [ 133 , 134 ] or in children with neurodevelopmental disorders [ 135 , 136 ]. In addition, the results in bilateral tasks cannot be compared to those of unilateral tasks as both types of tasks rely on different neural networks [ 137 , 138 ]. This review also included a large age range to explore the atypical maturation of motor processes from a developmental perspective.…”

Section: Discussionmentioning

confidence: 99%

Upper Limb Motor Planning in Individuals with Cerebral Palsy Aged between 3 and 21 Years Old: A Systematic Review

et al. 2021

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Individuals with cerebral palsy have difficulties performing activities of daily living. Beyond motor execution impairments, they exhibit motor planning deficits contributing to their difficulties. The objective of this review is to synthesize the behavioral evidence of motor planning deficits during an upper limb motor task in children, adolescents and young adults with cerebral palsy aged between 3 and 21 years. Methods: The inclusion criteria were: (1) including individuals with cerebral palsy from 3 to 21 years old; (2) assessing upper limb motor planning. Six databases were screened. The quality assessment of the studies was performed. Results: Forty-six studies and 686 participants were included. Five articles have been identified as very high quality, 12 as high, 20 as moderate, six as low, three as very low. Force planning studies reported a deficit for the more affected hand but adequate performances for the less affected hand. Object-manipulation studies reported hand posture planning deficits irrespectively of the hand assessed. Conclusions: Motor planning deficits has been shown in the more affected hand for force scaling, while the results for other variables showed overall deficits. Hence, variables affected by motor planning deficits in both hands should be considered in children with cerebral palsy to optimize intervention.

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Section: Discussionmentioning

confidence: 99%

Upper Limb Motor Planning in Individuals with Cerebral Palsy Aged between 3 and 21 Years Old: A Systematic Review

et al. 2021

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“…Greater damage to the motor area of the CC is associated with worse manual dexterity in the more and less affected hands [101]. Further, worse manual dexterity moderately relates to the reduced structural integrity of the CC [24]. Therefore, although the motor and sensory tracts show relationships with grasp impairments in children with USCP, the impairments may not be a sensory tract or motor tract problem.…”

Section: Relationship Between Sensory and Motor Information And The C...mentioning

confidence: 99%

“…The CC is thought to transfer somatosensory information between hemispheres [22,23]. However, children with USCP display structural abnormalities of the CC [24,25]. Thus, when the sensory and motor tracts are in different hemispheres and somatosensory information needs to be transferred between hemispheres, damage to the CC may further contribute to grasp impairments in children with this sensory-motor dissociation.…”

Section: Introductionmentioning

confidence: 99%

Neural Correlates of Impaired Grasp Function in Children with Unilateral Spastic Cerebral Palsy

Gutterman

Gordon

2023

Brain Sciences

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Unilateral spastic cerebral palsy (USCP) is caused by damage to the developing brain and affects motor function, mainly lateralized to one side of the body. Children with USCP have difficulties grasping objects, which can affect their ability to perform daily activities. Although cerebral palsy is typically classified according to motor function, sensory abnormalities are often present as well and may contribute to motor impairments, including grasping. In this review, we show that the integrity and connectivity pattern of the corticospinal tract (CST) is related to execution and anticipatory control of grasping. However, as this may not explain all the variance of impairments in grasping function, we also describe the potential roles of sensory and sensorimotor integration deficits that contribute to grasp impairments. We highlight studies measuring fingertip forces during object manipulation tasks, as this approach allows for the dissection of the close association of sensory and motor function and can detect the discriminant use of sensory information during a complex, functional task (i.e., grasping). In addition, we discuss the importance of examining the interactions of the sensory and motor systems together, rather than in isolation. Finally, we suggest future directions for research to understand the underlying mechanisms of grasp impairments.

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“…The CC is considered important for the efficient sensorimotor function of the whole body. The structural properties of CC have been repeatedly associated with the bimanual performance both in CP (Weinstein et al 2014 ; Hung et al 2019 ; Robert et al 2021 ) and in normal development (for a review, see Gooijers and Swinnen 2014 ). In addition, the severity of CP has been linked with the degree of the structural CC deficits: greater motor impairments according to the Gross Motor Functioning Classification Scale (GMFCS), have been associated with a smaller CC volume (Kułak et al 2007 ; Reid et al 2015 ) and decreased fractional anisotropy (FA) values in the CC (Lee et al 2011 ; Ballester-Plané et al 2017 ; Jiang et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Altered corpus callosum structure in adolescents with cerebral palsy: connection to gait and balance

Jaatela,

Nurmi,

Vallinoja

et al. 2023

Brain Struct Funct

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Cerebral palsy (CP) is the most common motor disorder in childhood. Recent studies in children with CP have associated weakened sensorimotor performance with impairments in the major brain white-matter (WM) structure, corpus callosum (CC). However, the relationship between CC structure and lower extremity performance, specifically gait and balance, remains unknown. This study investigated the transcallosal WM structure and lower limb motor stability performance in adolescents aged 10–18 years with spastic hemiplegic (n = 18) or diplegic (n = 13) CP and in their age-matched controls (n = 34). The modern diffusion-weighted MRI analysis included the diffusivity properties of seven CC subparts and the transcallosal lower limb sensorimotor tract of the dominant hemisphere. Children with CP had comprehensive impairments in the cross-sectional area, fractional anisotropy, and mean diffusivity of the CC and sensorimotor tract. Additionally, the extent of WM alterations varied between hemiplegic and diplegic subgroups, which was seen especially in the fractional anisotropy values along the sensorimotor tract. The diffusion properties of transcallosal WM were further associated with static stability in all groups, and with dynamic stability in healthy controls. Our novel results clarify the mechanistic role of the corpus callosum in adolescents with and without CP offering valuable insight into the complex interplay between the brain’s WM organization and motor performance. A better understanding of the brain basis of weakened stability performance could, in addition, improve the specificity of clinical diagnosis and targeted rehabilitation in CP.

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Corpus Callosum Integrity Relates to Improvement of Upper-Extremity Function Following Intensive Rehabilitation in Children With Unilateral Spastic Cerebral Palsy

Cited by 10 publications

References 60 publications

Upper Limb Motor Planning in Individuals with Cerebral Palsy Aged between 3 and 21 Years Old: A Systematic Review

Upper Limb Motor Planning in Individuals with Cerebral Palsy Aged between 3 and 21 Years Old: A Systematic Review

Neural Correlates of Impaired Grasp Function in Children with Unilateral Spastic Cerebral Palsy

Altered corpus callosum structure in adolescents with cerebral palsy: connection to gait and balance

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