Corpus callosum morphology in first-episode and chronic schizophrenia: combined magnetic resonance and diffusion tensor imaging study of Chinese Singaporean patients

Collinson, Simon L.; Gan, Swu Chyi; Woon, Puay San; Kuswanto, Carissa Nadia; Sum, Min Yi; Yang, Guo Liang; Lui, Ji Min; Sitoh, Yih Yian; Nowinski, Wiesław L.; Sim, Kang

doi:10.1192/bjp.bp.113.127886

Cited by 48 publications

(49 citation statements)

References 31 publications

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“…In the Arnone, et al meta-analysis, first episode patients were more likely to have decreased corpus callosum areas, and chronic patients were more likely to demonstrate an increase in area (Arnone et al, 2008). A more recent study of first-episode and chronic schizophrenia patients found decreased corpus callosum area and volume in all patients, but in comparing first-episode and chronic patients reported that chronicity contributed to greater decrease in four of five corpus callosum area segments; in fact, this particular study reported that first-episode patients only differed from healthy controls in two of five area regions (Collinson et al, 2014). One longitudinal study of the corpus callosum in adult-onset chronic schizophrenia patients demonstrated progressive decline in collosal size, with poor-outcome patients demonstrating more pronounced decline (Mitelman et al, 2009).…”

Section: 2 Structural Neuroimagingmentioning

confidence: 85%

Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings

Ordóñez

Luscher

Gogtay

2016

Schizophrenia Research

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Childhood onset schizophrenia (COS), with onset of psychosis before age 13, is a rare form of schizophrenia that represents a more severe and chronic form of the adult onset illness. In this review we examine structural and functional magnetic resonance imaging (MRI) studies of COS and non-psychotic siblings of COS patients in the context of studies of schizophrenia as a whole. Studies of COS to date reveal progressive loss of gray matter volume and cortical thinning, ventricular enlargement, progressive decline in cerebellar volume and a significant but fixed deficit in hippocampal volume. COS is also associated with a slower rate of white matter growth and disrupted local connectivity strength. Sibling studies indicate that non-psychotic siblings of COS patients share many of these brain abnormalities, including decreased cortical thickness and disrupted white matter growth, yet these abnormalities normalize with age. Cross-sectional and longitudinal neuroimaging studies remain some of the few methods for assessing human brain function and play a pivotal role in the quest for understanding the neurobiology of schizophrenia as well as other psychiatric disorders. Parallel studies in non-psychotic siblings provide a unique opportunity to understand both risk and resilience in schizophrenia.

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Section: 2 Structural Neuroimagingmentioning

confidence: 85%

Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings

Ordóñez

Luscher

Gogtay

2016

Schizophrenia Research

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“…In these cross-sectional studies, it was found that WM deficits in first-episode patients were either absent or less severe than in the multi-episode patients (Collinson et al, 2014; Friedman et al, 2008; Kong et al, 2011). Several studies have found greater FA decline with increasing age in schizophrenia patients, compared to healthy controls, from young-adulthood to late adulthood (reviewed by Peters et al (Peters et al, 2010)), which would be consistent with the model that includes decline after illness onset (i.e.…”

Section: White Matter Development In Schizophreniamentioning

confidence: 98%

“…DTI studies have produced evidence for WM abnormalities in first-episode patients (Cheung et al, 2011; Douaud et al, 2009; Luck et al, 2011; Peters et al, 2010; Rathi et al, 2011; Wang et al, 2011) and chronic patients (Konrad and Winterer, 2008), though findings are less consistent in the first-episode group. A significant portion of studies have shown no differences between first-episode patients and healthy individuals (Kong et al, 2011; Mulert and Scarr, 2012; Peters et al, 2010), while whole brain voxel-based analyses tend to produce positive findings and fiber tracking or region-of-interest analyses more often indicate no abnormalities (Collinson et al, 2014; Kong et al, 2011; Mulert et al, 2012; Peters et al, 2010). One factor that might contribute to the conflicting results is variability in medication status and symptom history, even in those individuals relatively early in the illness.…”

Section: White Matter Development In Schizophreniamentioning

confidence: 99%

White matter development in the early stages of psychosis

Peters

Karlsgodt

2015

Schizophrenia Research

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Schizophrenia has been conceptualized as a disorder of both neurodevelopment and a disorder of connectivity. One important aspect of the neurodevelopmental hypothesis is that schizophrenia is no longer thought to have discrete illness time points, but rather a long trajectory of brain changes, spanning many years, across a series of stages of the disease including the prodrome, first episode, and chronic period. As the disease progresses, there is a complex relationship between age related changes and disease related changes. Therefore, neural changes, and specifically white matter based connectivity changes, in schizophrenia may be best conceptualized based on a lifespan trajectory. In this selective review, we discuss healthy changes in white matter integrity that occur with age, as well as changes that occur across illness stages. We further propose a set of models that might explain lifespan changes in white matter integrity in schizophrenia, with the conclusion that the evidence most strongly supports a pattern of disrupted maturation during adolescence, with the potential for later changes that may be a result of disease neurotoxicity, abnormal or excessive aging effects, as well as medication, cohort or other effects. Thus, when considering white matter integrity in psychosis, it is critical to consider age in addition to other contributing factors including disease specific effects. Discovery of the factors driving healthy white matter development across the lifespan and deviations from the normal developmental trajectory may provide insights relevant to the discovery of early treatment interventions.

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“…In fact, it has been previously reported that callosal connections are altered in the brain of patients with schizophrenia, especially via reduction of the connection between the hemispheres [4]. It has also been reported that the volume of the corpus callosum, where the myelinated axons of the callosal projection neurons are located, is reduced in schizophrenia [27][28][29]. There is a possibility that FILIP is involved in the pathogenesis of schizophrenia through the reduction of cortico-cortical connections.…”

Section: Discussionmentioning

confidence: 99%

Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex

Yagi

Oka

Komada

et al. 2016

Neuroscience Letters

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Corpus callosum morphology in first-episode and chronic schizophrenia: combined magnetic resonance and diffusion tensor imaging study of Chinese Singaporean patients

Abstract: Morphological abnormalities in the corpus callosum may increase with illness progression.

Cited by 48 publications

References 31 publications

Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings

Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings

White matter development in the early stages of psychosis

Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex

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