Corpus Intra Cristam: A Dense Body Within Mitochondria of Cells in Hyperplastic Mouse Epidermis

Frei, J; Sheldon, H.

doi:10.1083/jcb.11.3.724

Cited by 46 publications

(15 citation statements)

References 15 publications

(10 reference statements)

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“…The st. corneum appears to show persistent lipid vesicles, an ultrastructural feature which has been previously reported in psoriatic epidermis (37). Mitochondrial aberrations similar to the ones which we observed in the fsn/fsn mice have been previously reported in hyperplastic mouse epidermis (38). Those authors suggested that they represented keratohyalin granules which continue to grow causing eventual dissolution of mitochondrial function (38).…”

Section: Discussionsupporting

confidence: 86%

Cutaneous Ultrastructural Features of the Flaky Skin (fsn) Mouse Mutation

Morita

Hogan

Nanney³

et al. 1995

The Journal of Dermatology

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An autosomal recessive genetic disease with clinical and histopathological skin features resembling human psoriasis vulgaris occurs naturally in flaky skin mice (fsn/fsn). Affected mice are normal at birth, except for a hypochromic anemia. Subsequently, they develop hyperkeratotic plaques and acanthosis with elongation of rete ridges. Scanning electron microscopic examination revealed a greatly thickened epidermis, a sparsity of hairs and scale accumulations on the epidermal surface. Hair shafts had conspicuous pits, striations, and exophytic protrusions. Nails were bent at a 90 degrees angle with surface irregularities and accumulations of scale at the nail base. Transmission electron microscopic examination showed increased epidermal thickness, mitochondrial aberrations, and intraepidermal invasion by neutrophils. Keratohyalin abnormalities were detected using immunocytochemical staining for profilaggrin. At the dermal-epidermal junction, numerous macrophages and mast cells were seen in close proximity to focal dissolutions of the basement membrane. A high density of collagen fibers and cellular infiltrates were evident in the papillary dermis. This constellation of ultrastructural aberrations is typically found in psoriasis vulgaris and supports the theory that the flaky skin mouse mutation is a naturally occurring analog to one variety of human psoriasis vulgaris.

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Section: Discussionsupporting

confidence: 86%

Cutaneous Ultrastructural Features of the Flaky Skin (fsn) Mouse Mutation

Morita

Hogan

Nanney³

et al. 1995

The Journal of Dermatology

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“…Several other investigators observed inclusions within keratinocyte mitochondria. A 1961 report describes mitochondrial inclusions in mouse epidermis made hyperplastic by the application of croton oil (15). The inclusions were termed "corpus intra cristam" and were considered to be involved in the formation of keratohyaline granules even though they were not demonstrated in normal mouse skin.…”

Section: Mitochondrial Inclusions In Keratinocytesmentioning

confidence: 99%

Mitochondrial inclusions in keratinocytes of hairless mouse skin exposed to UVB radiation

Feldman¹,

Bryce²,

Shapiro³

1990

J Cutan Pathol

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Mitochondrial inclusions were observed in keratinocytes during an ultrastructural investigation of the skin of hairless mice exposed to UVB radiation. Mice were irradiated 3 times a week for 5-6 months with sunlamps at individual doses seldom exceeding 0.06 J/cm2. Strips of dorsal skin were processed for electron microscopic examination; blocks were sectioned to include both epidermis and dermis. Mitochondrial inclusions were observed in keratinocytes of the basal, spinous and granular layers. They were spherical in shape and of moderate and homogeneous electron density. Mitochondria toward the upper regions of the epidermis were swollen and had fragmented cristae; mitochondria in the lower areas of the epidermis usually contained smaller and less dense inclusions and intact or partially disrupted cristae. Because mitochondria are essential in providing the energy for cellular function, keratinocyte mitochondrial damage induced by UVB radiation may have serious pathological consequences. Possible mechanisms involved in mitochondrial inclusion formation are suggested.

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“…Large internal bodies surrounded bv a halo were observed in mitochondria of Aconthonzoebo during cncvstationebv Viclterman (1960). Frei and Sheldon ( 1961) also discovered similar bodies in mitochondria in mouse e~idermal cells in resDonse to treatment with carcino-1 1 gens. In both instances.…”

mentioning

confidence: 89%