Corpus Luteum Development and Function in Cattle with Episodic Release of Luteinizing Hormone Pulses Inhibited in the Follicular and Early Luteal Phases of the Estrous Cycle1

Quintal-Franco, JA; Kojima, F. N.; Melvin, E.J.; Lindsey, B.R.; Zanella, Eraldo Lourenso; Fike, K. E.; Wehrman, M. E.; Clopton, Debra T.; Kinder, J. E.

doi:10.1095/biolreprod61.4.921

Cited by 41 publications

(14 citation statements)

References 25 publications

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“…Stress might also reduce fertility by negatively affecting CL formation. LH pulses after the pre‐ovulatory LH surge are necessary for both structural and functional CL development in cattle (Quintal‐Franco et al. 1999).…”

Section: Discussionmentioning

confidence: 99%

Endocrine and Ovarian Responses to Prolonged Adrenal Stimulation at the Time of Induced Corpus Luteum Regression

Gabai

Mollo

Marinelli

et al. 2006

Reprod Domestic Animals

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The endocrine and ovarian responses to prolonged adrenal stimulation at the time of corpus luteum (CL) regression were studied in non-lactating non-pregnant Friesian cows. Cows were synchronized with two cloprostenol (PG) injections 11 days apart (second PG referred as time 0). Experiment 1 was carried out on five animals in two phases with a resting period in between. Between -48 and 84 h, animals received 12 injections of either saline (CTR) or adrenocorticotrophic hormone (ACTH) agonist (Synacthen; SYN) every 12 h. Cortisol (C), progesterone (P4), oestradiol (E2) and LH were analysed in the blood samples collected every 8-12 h between days -3 and 4. Pulsatile LH release was studied 4 h before and 4 h after naloxone administration beginning at 96 h. Experiment 2 was carried out on four cows in a cross-over experimental design (two phases, with a resting period in between). Treatments were performed by administering either saline (CTR) or Synacthen (SYN) every 12 h between -36 and 24 h. The concentrations of C, P4 and E2 were measured in blood plasma every 4-12 h from days -3 to 3, then every day from days 5 to 9. In both experiments, ovaries were examined by ultrasonography every 1-3 days. ACTH administration induced a significant increase (p < 0.001) of plasma C lasting for 7 days (experiment 1), and for 3-4 days (experiment 2). Plasma C returned to baseline levels within 6 days (expt 1) or 36 h (expt 2) after treatment interruption. During the SYN phase, LH pre-ovulatory surge was not detectable. During the CTR phase, naloxone administration induced a significant increase (p< 0.05) of average LH concentrations that was not evident during the SYN phase. The dominant follicle development was retarded and mean plasma E2 concentrations were significantly lower during the SYN phase (p < 0.01). Luteolysis was completed within 2 days. However, P4 decline between 0 and 4 h was slower (p < 0.01) during the SYN phase. Our results indicate that, under prolonged adrenal stimulation, follicular development is delayed and LH release is impaired, which are independent of CL function.

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Section: Discussionmentioning

confidence: 99%

Endocrine and Ovarian Responses to Prolonged Adrenal Stimulation at the Time of Induced Corpus Luteum Regression

Gabai

Mollo

Marinelli

et al. 2006

Reprod Domestic Animals

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“…In the 1980s, it was demonstrated during the midluteal phase that the peak of a progesterone fluctuation occurs 10 min after the peak of an LH pulse [49]. The essentiality of LH for progesterone production by the bovine corpus luteum was well established in the 1990s [50]. During the past decade, the temporal and functional association between LH pulses and progesterone fluctuations have been clarified, and the involvement of both PGF and LH in progesterone rebounds have been demonstrated.…”

Section: Progesterone Rebounds and Lh-driven Progesterone Fluctuationmentioning

confidence: 99%

Dynamics of Circulating Progesterone Concentrations Before and During Luteolysis: A Comparison Between Cattle and Horses1

Ginther

Beg

2012

Biology of Reproduction

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The profile of circulating progesterone concentration is more dynamic in cattle than in horses. Greater prominence of progesterone fluctuations in cattle than in horses reflect periodic interplay in cattle between pulses of a luteotropin (luteinizing hormone; LH) and pulses of a luteolysin (prostaglandin F2alpha; PGF2alpha). A dose of PGF2alpha that induces complete regression of a mature corpus luteum with a single treatment in cattle or horses is an overdose. The overdose effects on the progesterone profile in cattle are an immediate nonphysiological increase taking place over about 30 min, a decrease to below the original concentration, a dose-dependent rebound 2 h after treatment, and a progressive decrease until the end of luteolysis. An overdose of PGF2alpha in horses results in a similar nonphysiological increase in progesterone followed by complete luteolysis; a rebound does not occur. An overdose of PGF2alpha and apparent lack of awareness of the rebound phenomenon has led to faulty interpretations on the nature of spontaneous luteolysis. A transient progesterone suppression and a transient rebound occur within the hours of a natural PGF2alpha pulse in cattle but not in horses. Progesterone rebounds are from the combined effects of an LH pulse and the descending portion of a PGF2alpha pulse. A complete transitional progesterone rebound occurs at the end of preluteolysis and the beginning of luteolysis and returns progesterone to its original concentration. It is proposed that luteolysis does not begin in cattle until after the transitional rebound. During luteolysis, rebounds are incomplete and gradually wane. A partial rebound during luteolysis in cattle is associated with a concomitant increase in luteal blood flow. A similar increase in luteal blood flow does not occur in mares.

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“…The comparatively poor beneficial impact of buserelin acetate on luteal profile can be justified by the less duration and amplitude of the induced LH surge which plays a role in optimum differentiation and growth rate of CL (Quintal-Franco et al 1999). In normal circumstances, the duration of preovulatory LH surge is 10 h (Chenault et al 1990), whereas GnRH analogueinduced LH surge starting 2 h after GnRH administration lasts to 7 h in buffalo (Roy and Prakash 2008).…”

Section: Discussionmentioning

confidence: 99%

Impact of Buserelin Acetate or hCG Administration on the Day of First Artificial Insemination on Subsequent Luteal Profile and Conception Rate in Murrah Buffalo (Bubalus bubalis)

Pandey

Ghuman

Dhaliwal

et al. 2016

Reprod Domestic Animals

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This study was designed to investigate the impact of buserelin acetate (BA) or human chorionic gonadotropin (hCG) administration on the day of first artificial insemination (AI) on subsequent luteal profile (diameter of corpus luteum (CL) and plasma progesterone) and conception rate in Murrah buffalo. The present experiment was carried out at two locations in 117 buffalo that were oestrus-synchronized using cloprostenol (500 μg) administered (i.m.) 11 days apart followed by AI during standing oestrus. Based on treatment (i.m.) at the time of AI, buffalo were randomly categorized (n = 39 in each group) into control (isotonic saline solution, 5 ml), dAI-BA (buserelin acetate, 20 μg) and dAI-hCG (hCG, 3000 IU) group. Out of these, 14 buffalo of each group were subjected to ovarian ultrasonography on the day of oestrus to monitor the preovulatory follicle and on days 5, 12, 16 and 21 post-ovulation to monitor CL diameter. On the day of each sonography, jugular vein blood samples were collected for the estimation of progesterone concentrations. All the buffalo (n = 117) were confirmed for pregnancy on day 40 post-ovulation. The conception rate was better (p < 0.05) in dAI-BA (51.3%) and dAI-hCG (66.7%) groups as compared to their control counterparts (30.8%). Furthermore, the buffalo of dAI-hCG group had improved (p < 0.05) luteal profile, whereas the buffalo of dAI-BA group failed (p > 0.05) to exhibit stimulatory impact of treatment on luteal profile when compared to control group. In brief, buserelin acetate or hCG treatment on the day of first AI leads to an increase in conception rate; however, an appreciable impact on post-ovulation luteal profile was observed only in hCG-treated Murrah buffalo.

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Corpus Luteum Development and Function in Cattle with Episodic Release of Luteinizing Hormone Pulses Inhibited in the Follicular and Early Luteal Phases of the Estrous Cycle1

Cited by 41 publications

References 25 publications

Endocrine and Ovarian Responses to Prolonged Adrenal Stimulation at the Time of Induced Corpus Luteum Regression

Endocrine and Ovarian Responses to Prolonged Adrenal Stimulation at the Time of Induced Corpus Luteum Regression

Dynamics of Circulating Progesterone Concentrations Before and During Luteolysis: A Comparison Between Cattle and Horses1

Impact of Buserelin Acetate or hCG Administration on the Day of First Artificial Insemination on Subsequent Luteal Profile and Conception Rate in Murrah Buffalo (Bubalus bubalis)

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