2023
DOI: 10.1002/mp.16657
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Correcting statistical CT number biases without access to raw detector counts: Applications to high spatial resolution photon counting CT imaging

Abstract: BackgroundDue to the nonlinear nature of the logarithmic operation and the stochastic nature of photon counts (N), sinogram data of photon counting detector CT (PCD‐CT) are intrinsically biased, which leads to statistical CT number biases. When raw counts are available, nearly unbiased statistical estimators for projection data were developed recently to address the CT number bias issue. However, for most clinical PCD‐CT systems, users' access to raw detector counts is limited. Therefore, it remains a challeng… Show more

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Cited by 1 publication
(2 citation statements)
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References 33 publications
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“…However, at extremely low exposure levels, the photon count at a detector element can be in single digits, rendering this leading-order approximation potentially inadequate. In such cases, it may be beneficial to include higher-order contributions and address potential zero counts, as recently demonstrated in CT number bias correction [55][56][57][58] by our research group. These advanced methods can significantly reduce the statistical bias of the estimator, resulting in an estimator that is almost free of statistical bias.…”
Section: Statistical Estimator Of Projection Data Variance From a Sin...mentioning
confidence: 95%
See 1 more Smart Citation
“…However, at extremely low exposure levels, the photon count at a detector element can be in single digits, rendering this leading-order approximation potentially inadequate. In such cases, it may be beneficial to include higher-order contributions and address potential zero counts, as recently demonstrated in CT number bias correction [55][56][57][58] by our research group. These advanced methods can significantly reduce the statistical bias of the estimator, resulting in an estimator that is almost free of statistical bias.…”
Section: Statistical Estimator Of Projection Data Variance From a Sin...mentioning
confidence: 95%
“…This method has been rigorously explored in our previous studies, especially in efforts to rectify CT number bias. [55][56][57][58]…”
Section: R E F E R E N C E Smentioning
confidence: 99%