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Silveira, Iani; Martinez, Brigitte

doi:10.7759/cureus.c67

Cited by 1 publication

(2 citation statements)

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“…1 Consequently, present day applications of CaHA-CMC routinely employ the practice of an on-label dilution volume of 0.26 mL (0.26 mL of diluent added to a 1.5 mL syringe of CaHA-CMC), or off-label dilution ratios of 1:1, 1:2, 1:3, 1:4, and 1:6. [8][9][10][11] In practice, CaHA-CMC is considered dilute at a 1:1 ratio and hyperdilute above a 1:1 dilution ratio. However, the extent to which aqueous dilution of these gels impacts their rheological properties and potential behavior within tissues has not been described.…”

Section: Introductionmentioning

confidence: 99%

“…This dilutional optimization stems from enhanced product spread that results in increased cell‐microsphere contact within the target tissue plane 1 . Consequently, present day applications of CaHA‐CMC routinely employ the practice of an on‐label dilution volume of 0.26 mL (0.26 mL of diluent added to a 1.5 mL syringe of CaHA‐CMC), or off‐label dilution ratios of 1:1, 1:2, 1:3, 1:4, and 1:6 8–11 . In practice, CaHA‐CMC is considered dilute at a 1:1 ratio and hyperdilute above a 1:1 dilution ratio.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dilutional rheology of Radiesse: Implications for regeneration and vascular safety

McCarthy,

Soares,

Chandawarkar

et al. 2024

J of Cosmetic Dermatology

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BackgroundCalcium hydroxylapatite‐carboxymethylcellulose (CaHA‐CMC) injectables have emerged as dual‐purpose fillers with bioregenerative and direct filling capabilities.AimsThis study investigates the rheological properties of CaHA‐CMC and its CMC carrier gel at various dilutions.MethodsThe storage modulus (G′), loss modulus (G″), complex viscosity (η*), loss factor (tan δ), cohesivity, and extrusion force were evaluated for a range of CaHA‐CMC aqueous dilutions with an oscillatory rheometer, drop weight testing, and force analysis, respectively.ResultsResults revealed a significant decrease in G′, η*, and increase in tan(δ) with increasing dilution, indicating a decline in the product's direct filling capabilities. Cohesivity decreased dramatically with dilution, potentially enhancing tissue biointegration and the product's biostimulatory effects. The CMC gel carrier displayed inelastic and non‐resilient properties, with rheological changes differing from CaHA‐CMC. Dilutional rheology was also correlated with previously published dilution‐dependent biostimulatory data where hyperdiluted CaHA‐CMC (>1:2) demonstrated a regenerative profile and diluted or hypodiluted mixtures retained meaningful filling properties and increased regeneration.ConclusionsThese findings offer a continuum for tailoring the product's rheological profile to match specific tissue requirements. Customizable rheology allows CaHA‐CMC to be tuned for either filling and contouring or optimal regenerative effects. Importantly, safety implications related to vascular occlusion suggest that dilutional rheomodulation decreases the risk of vascular events. In conclusion, this study highlights the significant impact of aqueous dilution on the rheological properties of CaHA‐CMC and its carrier gel. The findings support the clinical application of tailored dilutions to achieve desired outcomes, providing versatility and safety for aesthetic applications.

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