Correction

Abstract

Introduction Gastroesophageal reflux disease (GERD) influences patients' general health, daily and social functioning, and physical and emotional activities. It strongly affects the health-related quality of life with frequent interruptions during sleep, work, and social activities. GERD is defined as a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications. GERD symptoms are a major concern for many patients, as they cause a disturbance in physical, social and emotional health. In this study, we determine the prevalence of anxiety and depression in patients with GERD with and without chest pain. Methods In this cross-sectional study, a total of 258 consecutive patients with a diagnosis of GERD were included in this study. Of 258 participants, 112 had concerns about chest pain. Clinical presentations and comorbid disorders were evaluated by a previously validated gastroesophageal reflux symptom questionnaire. Depressive and anxious symptoms were assessed using a Hospital Anxiety/Depression Scale. Results A total of 107 (41.4%) participants had depression, 89 (34.4%) participants had anxiety, and 70 (27.13%) had both depression and anxiety. Depression and anxiety were significantly higher in patients with GERD and chest pain. Conclusion Anxiety and depression were significantly higher in patients with GERD, particularly those who also reported concerns of chest pain. Measures should be taken to reduce the stress and anxiety of GERD patients to cope with their daily life activities and improve their quality of life.

association of anxiety and depression among health specialties students with GERD in Makkah city, kingdom of Saudi Arabia (KSA). Cross-sectional study

“…Still, the correlation between the severity of symptoms of GERD and pathophysiological abnormalities is not significant. This supports the concept that psychological factors strongly affect GERD symptoms [31,33]. Limited studies globally have been investigating the relationship between depression and anxiety and GERD symptoms; however, no constant outcome from those studies [31,34].…”

“…Psychological factors complicate the treatment of functional GI disorder, resulting in poor outcomes [31][32]. Still, the correlation between the severity of symptoms of GERD and pathophysiological abnormalities is not significant.…”

Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder

“…Ample scientific reports indicated that the clinical characteristics of anxiety and GI dysfunctions coexist to a more significant extent [ 24 , 25 ]. To note, the pestilent symptoms of both anxiety and GI disorders have been mutually known to predispose and exacerbate the pathogenic signatures between them but the definitely combined etiology of these diseases remains obscure due to their co-morbid nature [ 24 , 26 , 27 ]. However, the experimental data on the shared biology and underlying synergistic pathomechanisms responsible for anxiety and GI disorders are highly limited.…”

Anxiety and depression in school-age patients with spinal muscular atrophy: a cross-sectional study

“…A study on Parkinson's disease (PD) patients showed that severe constipation and motor symptoms were closely related to depression; the researchers explained that involvement of the enteric plexus of the gastrointestinal tract and dorsal motor nucleus of the vagus (DMV) initially causes constipation in PD patients, and subsequent spread to the raphe nuclei and locus coeruleus leads to depressive mood [33]. Furthermore, gastroesophageal reflux reduces the quality of life of patients, so that the long-term course of disease promotes an increase in psychological pressure and damage to mental health, leading to anxiety and depression [6].…”

“…Somatic diseases play an extremely important role in the occurrence and development of mental disorders. Numerous studies have shown that patients with somatic diseases-including asthma, allergic rhinitis, stroke, multiple sclerosis, inflammatory bowel disease, leukemia, cancer, and other chronic diseasesfrequently suffer from anxiety and depression [5][6][7][8][9]. Anxiety is the most common mental health disorder in childhood; it is also among the earliest psychiatric conditions to manifest, at a median age of 11 years [10].…”