Correction: A new family of fullerene derivatives: fullerene–curcumin conjugates for biological and photovoltaic applications

Castro, Edison; Cerón, Maira R.; Garcia, Andrea Hernandez; Kim, Quentin; Etcheverry-Berríos, Álvaro; Morel, Mauricio J.; Díaz-Torres, Raúl; Qian, Wenjie; Martinez, Zachary; Méndez, Lois; Perez, Frank; Santoyo, Christy A.; Gimeno-Muñoz, Raquel; Esper, Ronda; Gutierrez, Denisse A.; Varela-Ramı́rez, Armando; Aguilera, Renato J.; Llano, Manuel; Soler, Mónica; Aliaga‐Alcalde, Núria; Echegoyen, Luís

doi:10.1039/c9ra90002k

Cited by 3 publications

(8 citation statements)

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“…Due to the special properties of fullerenes, it is currently a prominent topic in many areas of nanomaterial research. There have been many experimental studies using this material to form a drug carrier system and have shown a significant improvement in the pharmacokinetic properties of the active substance 9,10 . Curcumin is a natural compound extracted from turmeric, which has many pharmacological properties such as antiviral, antibacterial, anti-cancer.…”

Section: Science and Technology Development Journal 24(si1):si51-si62mentioning

confidence: 99%

“…For fullerenes, there are also some computational simulation studies such as the structure, the antioxidant capacity of some polyphenols, and fullerene derivatives (C60) by using the computational chemistry method by Nguyen Minh Thong 12 . Castro E. Cerón and colleagues conducted an experimental study to create externally bound to fullerenes 10 . Although, as we can see in Figure 4, the fullerene derivative with curcumin by Castro E. Cerón et al 10 , the curcumin molecule binds outside the surface of the fullerene.…”

Section: Si52mentioning

confidence: 99%

“…Castro E. Cerón and colleagues conducted an experimental study to create externally bound to fullerenes 10 . Although, as we can see in Figure 4, the fullerene derivative with curcumin by Castro E. Cerón et al 10 , the curcumin molecule binds outside the surface of the fullerene. This makes curcumin more easily exposed to and destroyed by external factors.…”

Section: Si52mentioning

confidence: 99%

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Interaction of curcumin molecule with fullerene material by simulation method

Le,

Lam,

Tran

2021

Sci. Tech. Dev. J.

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The designs of target-drug delivery systems are attractively concerned due to their efficacy and safety. Fullerene is the first symmetrical carbon nanomaterial invented in the world. Due to the special properties of fullerene, it is an emergent topic in nanomaterials in recent years. Many experimental studies used this material to form the drug-carrier system and have shown a significant improvement in the pharmacokinetic properties of the active substance. Curcumin is a natural compound extracted from turmeric, with many pharmacological properties such as antiviral, antibacterial, and impact on cancer cells, etc. However, curcumin's pharmacological properties are hardly clinically demonstrated due to its water-solubility. A fullereo-curcuminoid derivative to HIV viruses and cancer cells was created, in which curcumin is out-bound to fullerene. HIV antiviral properties showed only moderate efficiency, and no anti-cancer effect was observed. Another disadvantage of the out-bound fullereo-curcuminoid derivative is that it is hard to control the number of curcumin-derivative molecules that bind out-surfaced fullerene, which is a critical problem we need to deal with since curcumin overdose causes side effects to the digestive system, skin, or headache. For the above reasons, we decided to conduct this research, focusing on the computational approach of in-bound fullereo-curcuminoid derivative systems for drug delivery, with adequate fullerene size to encapsulate curcumin molecules. This proposed model is promising not only to create a better anti-solvent shield for the curcumin molecule throughout the delivery path to the target cells but also to manipulate the curcumin dose since the fullerene shield may increase the efficiency of curcumin carrying. This research uses the computational simulation method to investigate the epidermal growth factor (EGF) receptor binding and the physicochemical parameters of the curcumin molecule encapsulated in fullerene. The density functional theory (DFT) calculation is conducted to observe the electrical and energetic properties of the curcumin-fullerene encapsulation system. The obtained system is then docked with the target receptor. After that, the size-modified defected gap will be created on the fullerene surface in the release process of the curcumin out of the fullerene. To interact with the target residues on the receptor will be observed by using MD simulation and their interaction stabilization.

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Section: Science and Technology Development Journal 24(si1):si51-si62mentioning

confidence: 99%

Section: Si52mentioning

confidence: 99%

Section: Si52mentioning

confidence: 99%

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Interaction of curcumin molecule with fullerene material by simulation method

Le,

Lam,

Tran

2021

Sci. Tech. Dev. J.

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“…Carbon nano materials (CNMs) including graphene quantum dots (GQDs), carbon nano tubes (CNTs), carbon nano onions (CNOs), and carbon dots (CDs) have been exploited for their wide- spread applications as sensors, in catalysis, tissue engineering and cancer therapy. − A relatively recent article revealed the ability of graphene quantum dots (GQDs) to inhibit the fibrillization of the Parkinson’s Disease (PD)-associated amyloid α-synuclein . The GQDs were able to directly interact with mature fibrils and trigger their disaggregation.…”

Section: Introductionmentioning

confidence: 99%

Carbon Quantum Dots for Treatment of Amyloid Disorders

Guerrero

Lopez-Velazquez

Ahlawat

et al. 2021

ACS Appl. Nano Mater.

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Prion-like amyloids self-template and form toxic oligomers, protofibrils, and fibrils from their soluble monomers; a phenomenon that has been implicated in the onset and progress of neurodegenerative disorders such as Alzheimer's (AD), Parkinson's (PD), Huntington's, and systemic lysozyme amyloidosis. Carbon quantum dots (CQDs), sourced from Na−citrate as a carbon precursor were synthesized and characterized before being tested for their ability to intervene in amyloidogenic (fibrilforming) trajectories. Hen-egg white lysozyme (HEWL) served as a model amyloidogenic protein. A pulse-chase lysozyme fibrilforming assay developed to examine the impact of CQDs on the HEWL amyloid-fibril-forming trajectory used ThT fluorescence as a reporter of mature fibril presence. The results revealed that the Na−citrate-derived CQDs were able to intervene at multiple points along the fibril-forming trajectory by preventing the conversion of both monomeric and oligomeric HEWL intermediates into mature fibrils. In addition, and importantly, the carbon nano material (CNM) was able to dissolve oligomeric HEWL into monomeric HEWL and provoke the disaggregation of mature HEWL fibrils. These results suggest that Na−citrate CQD's intervene in amyloidogenesis by multiple mechanisms. The gathered data, coupled with cell-line results demonstrating the relatively low cytotoxicity of Na−citrate CQDs, suggest that this emerging CNM has the potential to intervene both prophylactically and therapeutically in protein misfolding diseases. The aforementioned findings are likely to enable Na−citrate CQDs to eventually transition to both cell-line and preclinical models of protein-misfolding-related disorders. Importantly, the study outcomes positions Na−citrate CQDs as an important class of chemical, nanotechnological, and biobased interventional tools in neuroscience.

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“…In recent decades, graphitic nanomaterials such as fullerene, carbon nanotubes, and graphene have been widely used in bioanalysis and biomedicine due to their unique physical and chemical properties, versatile natures, and negligible toxicities . To date, a variety of graphitic nanomaterial‐based applications have facilitated the development of biomedical applications, such as carbon quantum‐dot‐based biosensors and imaging systems, graphene oxide‐based biosensors and drug delivery systems, and carbon nanotube‐based therapy applications .…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Multifunctional Graphitic Nanocapsules for Raman Detection, Imaging, and Therapy

Liu

Zhu

et al. 2019

Small Methods

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To date, a variety of graphitic nanomaterial-based applications have facilitated the development of biomedical applications, such as carbon quantumdot-based biosensors and imaging systems, [14][15][16][17] graphene oxide-based biosensors [18][19][20][21][22] and drug delivery systems, [20,[23][24][25] and carbon nanotube-based therapy applications. [26][27][28][29] Compared with other widely used nanomaterials, graphitic nanomaterials show superior fluorescence quenching performance, larger Raman scattering cross-sections than conventional organic Raman tags, [30] and better biocompatibility. [31] With the goal of broadening their applications, great attention has been focused on integrating graphitic materials with other inorganic nanomaterials such as noble metals [32,33] and magnetic nanomaterials. [34,35] Such graphitic nanomaterial-metal hybrid nanostructures make full use of the excellent properties of both graphitic and metal nanomaterials, and have much wider application prospect in bioanalysis. [36] However, most of the reported hybrid nanostructures, in which metal nanomaterials are exposed on the surface of graphitic nanomaterials encounter difficulty in maintaining their morphologies and stable properties under harsh conditions, such as long-term laser irradiation or strong acidic environments, which might cause inaccurate bioanalytical results and even potential biotoxicity. [37][38][39] Therefore, it is critical to prepare novel graphitic nanomaterials with superstability to meet the demands of reliable bioanalysis and biomedicine.As a type of novel graphite nanomaterial with a core-shell structure, superior physicochemical properties, good biocompatibility, superior stability, and controllable size, graphitic nanocapsules have been extensively applied in biosensing, [40,41] bioimaging, [42,43] drug delivery, [43,44] and cancer treatment. [45] Benefiting from the large surface area of the outside graphitic shell, graphitic nanocapsules supply superior nanoplatforms for drugs and targeting-molecule loading, which further broadens their biomedical applications. [42,44,46] In addition, the graphitic shell of graphitic nanocapsules possesses several unique Raman scattering bands and can act as a Raman signal tag or stable internal standard (IS) for accurate surface enhanced Raman scattering (SERS) analysis. [46,47] Particularly, the 2D band (≈2650 cm −1 ) within the cellular Raman-silent region is beneficial to avoiding the interference signals from Benefiting from their unique physicochemical properties, graphitic nanocapsules with a core-shell structure have attracted tremendous interest in bioanalysis and biomedicine recently. Using rational design, various types of graphitic nanocapsules with controllable properties are prepared to meet the demands of different biomedical applications. Graphitic nanocapsules exhibit excellent stability and superior capacity for loading nucleic acids, proteins, small molecules, and drugs due to the large specific surface area of their graphitic shells. Moreover, usin...

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Correction: A new family of fullerene derivatives: fullerene–curcumin conjugates for biological and photovoltaic applications

Abstract: Correction for ‘A new family of fullerene derivatives: fullerene–curcumin conjugates for biological and photovoltaic applications’ by Edison Castro et al., RSC Adv., 2018, 8, 41692–41698.

Cited by 3 publications

References 0 publications

Interaction of curcumin molecule with fullerene material by simulation method

Interaction of curcumin molecule with fullerene material by simulation method

Carbon Quantum Dots for Treatment of Amyloid Disorders

Recent Advances in Multifunctional Graphitic Nanocapsules for Raman Detection, Imaging, and Therapy

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