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Shah, Neha; Jadidi, Shaheen; Bajaj, Prempreet Singh

doi:10.7759/cureus.c45

Cited by 3 publications

(4 citation statements)

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“…CA is conditionally divided into primary and secondary. The primary one occurs in previously healthy cartilage under the influence of increased load, in the case of the secondary one, degradation of previously changed articular cartilage occurs under the influence of even a normal load [13]. According to the classification developed by the American College of Rheumatology, idiopathic (localized and generalized) CA belongs to primary, and forms that occur against the background or after suffered diseases or injuries (post-traumatic, dysplastic, dysmetabolic) belong to secondary [13].…”

Section: Introductionmentioning

confidence: 99%

Biochemical Markers of Blood Serum and Articular Cartilage in Different Forms of Idiopathic Coxarthrosis Progression

Magomedov,

Kalashnikov,

Polishchuk

et al. 2024

OTP

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Deformation due to arthrosis of the hip joint affects 40 % of the total number of patients with osteoarthritis, which is from 7 to 25 % of the adult population. For the activity of the pathological process evaluation we studied biochemical changes in the metabolism of collagen, namely: glycosaminoglycans (GAG), hydroxyproline (HP) fractions, collagenase, hyaluronidase activity, etc. Objective. To determine the biochemical changes in blood serum and articular cartilage depending on the form of progression of idiopathic coxarthrosis. Methods. 23 patients were examined (8 (34.8 %) men, 15 (65.2 %) women, age 45‒75 years and more) with idiopathic arthrosis of the hip joint IV stage (Kellgren–Lawrence). Progression forms of idiopathic coxarthrosis were distinguished: group I — rapid (the period from the initial to the final stage of the disease was 5 years and less), II — moderate (5‒10 years), III — slow (over 10 years). Collagenase activity, HP fractions, total GAG content were determined in patients’ blood serum, and collagen content was determined in the cartilage tissue of the femoral head. Results. Compared with the age reference norm in the blood serum of patients of group I activity collagenase increased to 114 %, in II and III — 122 and 135 %, respectively; the content of the free fraction of GP — up to 111, 169, 128 %, respectively; GAG concentrations — up to 110, 122, and 135 %, respectively; protein-bound HP was reduced to 60% in group II, up to 84 % — in group III. In cartilage tissue, the GAG content decreased in group III to 63 %, II — 55 %, I — 47 %; collagen — 32, 25, 24 % in accordance. Conclusions. The course of idiopathic coxarthrosis is determined by metabolic changes in the components of the organic basis of connective and cartilaginous tissues in blood serum. The most profound changes were found in the synthetic phase of HP metabolism, especially in the group with a rapid course disease. A decrease in the content of organic components of connective tissue (GAG and collagen) was determined

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Section: Introductionmentioning

confidence: 99%

Biochemical Markers of Blood Serum and Articular Cartilage in Different Forms of Idiopathic Coxarthrosis Progression

Magomedov,

Kalashnikov,

Polishchuk

et al. 2024

OTP

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“…The pathogenesis of RA is not fully known due to the lack of knowledge regarding the etiology of this disease ( 3 ). The preliminary event in RA pathogenesis is believed to be the presence of immune complexes in the bloodstream, which is considered the pre-articular phase, during which the generation of autoantibodies against host tissue occurs ( 4 ). Notably, certain serological markers can be detected to diagnose disease initiation during this phase, such as citrulline antibodies ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Ubiquitin D promotes the progression of rheumatoid arthritis via activation of the p38 MAPK pathway

et al. 2023

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Ubiquitin D (UBD), a member of the ubiquitin-like modifier family, has been reported to be highly expressed in various types of cancer and its overexpression is positively associated with tumor progression. However, the role and mechanism of UBD in rheumatoid arthritis (RA) remain elusive. In the present study, the gene expression profiles of GSE55457 were downloaded from the Gene Expression Omnibus database to assess differentially expressed genes and perform functional enrichment analyses. UBD was overexpressed by lentivirus transfection. The protein level of UBD, p-p38 and p38 in RA-fibroblast-like synoviocytes (FLSs) were examined by western blotting. Cell Counting Kit-8 and flow cytometry assays were used to detect the functional changes of RA-FLSs transfected with UBD and MAPK inhibitor SB202190. The concentrations of inflammatory factors (IL-2, IL-6, IL-10 and TNF-α) were evaluated using ELISA kits. The results revealed that UBD was overexpressed in RA tissues compared with in the healthy control tissues. Functionally, UBD significantly accelerated the viability and proliferation of RA-FLSs, whereas it inhibited their apoptosis. Furthermore, UBD significantly promoted the secretion of inflammatory factors (IL-2, IL-6, IL-10 and TNF-α). Mechanistically, elevated UBD activated phospohorylated-p38 in RA-FLSs. By contrast, UBD overexpression and treatment with the p38 MAPK inhibitor SB202190 not only partially relieved the UBD-dependent effects on cell viability and proliferation, but also reversed its inhibitory effects on cell apoptosis. Furthermore, SB202190 partially inhibited the effects of UBD overexpression on the enhanced secretion of inflammatory factors. The present study indicated that UBD may mediate the activation of p38 MAPK, thereby facilitating the proliferation of RA-FLSs and ultimately promoting the progression of RA. Therefore, UBD may be considered a potential therapeutic target and a promising prognostic biomarker for RA.

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“…[1,2] Initially, OA patients experience deterioration in the cartilage resulting in inflammation and destruction of the joints surround-ing tissues, including the cartilage, synovium, and bone. [3][4][5] It is not possible to restore the health of the damaged cartilage, and therefore, it is essential to properly manage OA. Generally, OA treatment is primarily directed at alleviating pain and elevating functionality.…”

Section: Introductionmentioning

confidence: 99%

“…It is a progressive and chronic musculoskeletal condition [1,2] . Initially, OA patients experience deterioration in the cartilage resulting in inflammation and destruction of the joints surrounding tissues, including the cartilage, synovium, and bone [3–5] . It is not possible to restore the health of the damaged cartilage, and therefore, it is essential to properly manage OA.…”

Section: Introductionmentioning

confidence: 99%

Clinical therapeutic effects of combined diacerein and glucosamine in the treatment of osteoarthritis

Wang

Wei-xing²,

Chen³

et al. 2021

Medicine

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Background: Osteoarthritis (OA) has been identified as a common musculoskeletal condition. As a chronic condition, OA adversely impact the hip and knee joints. Surgical treatment for hip and knee osteoarthritis is associated with high financial and long recovery processes. Therefore, patients are continually searching for alternative methods of treatment. Diacerein is regarded as symptom-modifying, slow-acting drug that could most likely change the disease structure of OA. The present systematic review protocol explains methods utilized to evaluate the clinical therapeutic effects of combining diacerein and glucosamine to treat OA.Methods: The authors will conduct a search for randomized controlled trials comparing diacerein plus glucosamine with diacerein alone, glucosamine alone, or another treatment in patients with OA. The search will be done in the following online-based databases: EMBASE, MEDLINE, Cochrane Library, Web of Science, China National Knowledge Infrastructure, and WanFang Database. All related RCTs included from inception to September 29, 2021 are included. Two authors will independently conduct data abstraction and quality assessment, and the comparative analysis will compare the results. The present meta-analysis will be performed with the RevMan software (version 5.3), where the results will be expressed as relative risk, mean differences, or standardized mean differences with 95% confidence intervals.Results: This study will be conducted to evaluate the clinical therapeutic effects of combined diacerein and glucosamine in the treatment of OA. Conclusion:The summary presented in the study will ascertain whether diacerein plus glucosamine intervention is an efficient and feasible method of treatment for OA patients.

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Cited by 3 publications

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Biochemical Markers of Blood Serum and Articular Cartilage in Different Forms of Idiopathic Coxarthrosis Progression

Biochemical Markers of Blood Serum and Articular Cartilage in Different Forms of Idiopathic Coxarthrosis Progression

Ubiquitin D promotes the progression of rheumatoid arthritis via activation of the p38 MAPK pathway

Clinical therapeutic effects of combined diacerein and glucosamine in the treatment of osteoarthritis

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