Correction: Accuracy of a screening tool for medication adherence: A systematic review and meta-analysis of the Morisky Medication Adherence Scale-8

Moon, Sun Jae; Lee, Weon-Young; Hwang, Jin-soo; Hong, Yeon Pyo; Morisky, Donald E.

doi:10.1371/journal.pone.0196138

Cited by 10 publications

(15 citation statements)

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“…Finally, the MMAS-8 has been used in 12 RCTs of treatments for acute coronary syndrome, diabetes mellitus, hypertension, chronic heart failure, and malignant neoplasms. 6 There have been some criticisms of the MMAS-8. Moon et al stated, “for a cut-off value of 6, the MMAS-8 in a meta-analysis showed the pooled sensitivity and specificity in 12 studies were 0.43 (95% CI, 0.33 to 0.53) and 0.73 (95% CI, 0.68 to 0.78), respectively,” so as with any other score, there is not a uniform association with outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Moon et al stated, “for a cut-off value of 6, the MMAS-8 in a meta-analysis showed the pooled sensitivity and specificity in 12 studies were 0.43 (95% CI, 0.33 to 0.53) and 0.73 (95% CI, 0.68 to 0.78), respectively,” so as with any other score, there is not a uniform association with outcomes. 6 Finally, Muntner et al assessed what was the minimal detectable change for scores on the MMAS-8; and, their results suggested that within-person changes in MMAS-8 scores of 2 or more points over time might represent a real change in antihypertensive medication adherence. 21 …”

Section: Discussionmentioning

confidence: 99%

“…Also, as Moon et al stated, “for a cut-off value of 6, the MMAS-8 in a meta-analysis showed the pooled sensitivity and specificity in 12 studies were 0.43 (95% CI, 0.33 to 0.53) and 0.73 (95% CI, 0.68 to 0.78), respectively,” so as with any other score, there is not a uniform association with outcomes. 6 Another issue is the validity of the MMAS in chronic disease (and more particularly in chronic kidney disease) and correlation to specific clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Using a cut-point of less than 6 on the MMAS-8, the sensitivity and specificity of the 8-item scale for identifying low vs. higher adherers were estimated to be 93% and 53%, respectively. 6 One of the a priori areas of focus in the SPRINT trial was the influence of medication adherence on clinical outcomes, so we assessed whether lower medication adherence was predictive of worse BP control and more frequent cardiovascular outcomes, regardless of the intervention assignment.…”

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confidence: 99%

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Is Medication Adherence Predictive of Cardiovascular Outcomes and Blood Pressure Control? The Systolic Blood Pressure Intervention Trial (SPRINT)

Glasser

Vitolins

Rocco

et al. 2021

American Journal of Hypertension

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Background Adherence to study medications is crucial to evaluating treatment effects in clinical trials. Objective To assess whether in the SPRINT Trial, adherence and cardiovascular outcomes are associated regardless of intervention assignment. Methods This study included 9361 participants aged ≥ 50 years, recruited from 102 clinics. Participants were randomized to a Standard Treatment Group (targeted SBP <140 mmHg) or an Intensive Treatment Group (targeted SBP <120 mmHg) and followed for incident cardiovascular events until the study was halted early for benefit. The 8-item Morisky Medication Adherence Scale (MMAS-8) was administered at baseline, and at the 12 and 48-month (or close out) visit. Results Adjusting for covariates, there was no association between the baseline 8-item MMAS-8 and the likelihood of the primary composite endpoint, any of the secondary endpoints, or BP control. Low adherence was associated with a higher BMI, SBP, DBP, and PHQ-9, and high adherence was associated with a higher MOCA. There was no difference in the MMAS-8 over time by treatment arm assignment. For the Primary outcome (a composite of myocardial infarction, other acute coronary syndromes, stroke, heart failure, or death from cardiovascular causes), baseline odds ratios (95% confidence intervals) for the Low vs Medium and vs High; and, for Medium vs High MMAS-8 were 1.02 (0.82-1.28), 1.07 (0.85-1.34), and 1.05 (0.88-1.250). Conclusion In SPRINT, medication adherence as measured using the MMAS-8 was not associated with outcomes or BP control.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Is Medication Adherence Predictive of Cardiovascular Outcomes and Blood Pressure Control? The Systolic Blood Pressure Intervention Trial (SPRINT)

Glasser

Vitolins

Rocco

et al. 2021

American Journal of Hypertension

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“…Each answer is scored 0 or 1. The MMAS-8 has been previously used for a wide range of diseases and is validated for both DM and HTN [9,14,15]. More recently, the MMAS-8 was used in studies assessing self-reported adherence in Arabic speaking populations, such as the United Arab Emirates (UAE), Saudi Arabia, Jordan, and Palestine [5,9,[16][17][18].…”

Section: Cross-sectional Componentmentioning

confidence: 99%

Self-reported medication adherence among patients with diabetes or hypertension, Médecins Sans Frontières Shatila refugee camp, Beirut, Lebanon: A mixed-methods study

Mohamad

Moussally²,

Lakis³

et al. 2021

PLoS ONE

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Introduction Low adherence to medications, specifically in patients with Diabetes (DM) and Hypertension (HTN), and more so in refugee settings, remains a major challenge to achieving optimum clinical control in these patients. We aimed at determining the self-reported medication adherence prevalence and its predictors and exploring reasons for low adherence among these patients. Methods A mixed-methods study was conducted at Médecins Sans Frontières non-communicable diseases primary care center in the Shatila refugee camp in Beirut, Lebanon in October 2018. Data were collected using the validated Arabic version of the 8-items Morisky Medication Adherence Scale (MMAS-8) concurrently followed by in-depth interviews to explore barriers to adherence in patients with DM and/or HTN. Predictors of adherence were separately assessed using logistic regression with SPSS© version 20. Manual thematic content analysis was used to analyze the qualitative data. Results Of the 361 patients included completing the MMAS, 70% (n = 251) were moderately to highly adherent (MMAS-8 score = 6 to 8), while 30% (n = 110) were low-adherent (MMAS-8 score<6). Patients with DM-1 were the most likely to be moderately to highly adherent (85%; n = 29). Logistic regression analysis showed that patients with a lower HbA1C were 75% more likely to be moderately to highly adherent [(OR = 0.75 (95%CI 0.63–0.89), p-value 0.001]. Factors influencing self-reported moderate and high adherence were related to the burden of the disease and its treatment, specifically insulin, the self-perception of the disease outcomes and the level of patient’s knowledge about the disease and other factors like supportive family and healthcare team. Conclusion Adherence to DM and HTN was good, likely due to a patient-centered approach along with educational interventions. Future studies identifying additional factors and means addressing the barriers to adherence specific to the refugee population are needed to allow reaching optimal levels of adherence and design well-informed intervention programs.

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Association between adherence to oral therapies in cancer patients and clinical outcome: A systematic review of the literature

Lasala

Santoleri

2021

Brit J Clinical Pharma

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which considered the use of oral anticancer drugs for cancer patients and which correlated treatment adherence with a clinical outcome, were considered. Results:From the 42 studies considered in the systematic review, 14 were for oncological indications and 28 for haematological indications. There was considerable variance in calculation methods, outcomes considered, and in the definitions of adherence. However, it emerged that most studies reported a significant correlation between adherence to therapy and clinical outcome. Conclusion:As adherence to therapy is a key factor in achieving a better clinical outcome, future studies with large samples, robust endpoints and the use of at least two methods of assessing adherence would be desirable in order to produce more robust evidence.

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Correction: Accuracy of a screening tool for medication adherence: A systematic review and meta-analysis of the Morisky Medication Adherence Scale-8

Cited by 10 publications

References 1 publication

Is Medication Adherence Predictive of Cardiovascular Outcomes and Blood Pressure Control? The Systolic Blood Pressure Intervention Trial (SPRINT)

Is Medication Adherence Predictive of Cardiovascular Outcomes and Blood Pressure Control? The Systolic Blood Pressure Intervention Trial (SPRINT)

Self-reported medication adherence among patients with diabetes or hypertension, Médecins Sans Frontières Shatila refugee camp, Beirut, Lebanon: A mixed-methods study

Association between adherence to oral therapies in cancer patients and clinical outcome: A systematic review of the literature

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