Correction: Aljabali, A.A.A.; et al. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer via down Regulation of Nuclear p65 and HIF-1α. Cancers 2020, 12, 113

Aljabali, Alaa A. A.; Bakshi, Hamid A.; Hakkim, Faruck Lukmanul; Haggag, Yusuf A.; Al-Batanyeh, Khalid M.; Zoubi, Mazhar Salim Al; Al‐Trad, Bahaa; Nasef, Mohamed Mahmoud; Satija, Saurabh; Mehta, Meenu; Pabreja, Kavita; Mishra, Vijay; Khan, Mohammed Naeem; Abobaker, Salem; Azzouz, Ibrahim M.; Dureja, Harish; Pabari, Ritesh M.; Dardouri, Ashref Ali K.; Kesharwani, Prashant; Gupta, Gaurav; Shukla, Shakti D.; Prasher, Parteek; Charbe, Nitin; Negi, Poonam; Kapoor, Deepak; Chellappan, Dinesh Kumar; Silva, Mateus Webba da; Thompson, Paul D.; Dua, Kamal; McCarron, Paul A.; Tambuwala, Murtaza M.

doi:10.3390/cancers12123587

Cited by 10 publications

(2 citation statements)

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“…Storage and transport also present challenges, including denaturation, oxidation, and aggregation [67,[190][191][192]. Several strategies have been developed to mitigate these challenges, including nanoencapsulation and PEGylation to prevent premature interactions and extend circulation half-life [193][194][195]. Modifying nanoparticle size and shape, utilizing enzyme-inhibiting coatings, and employing cryopreservation and lyophilization address issues related to immune evasion, enzymatic degradation, and structural integrity [196,197].…”

Section: Stability and Longevitymentioning

confidence: 99%

Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems

Wang,

et al. 2023

Preprint

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Biomimetic delivery systems (BDSs), inspired by the intricate designs of biological systems, have emerged as a groundbreaking paradigm in nanomedicine, offering unparalleled advantages in therapeutic delivery. These systems, encompassing platforms such as liposomes, protein-based nanoparticles, extracellular vesicles, and polysaccharides, are lauded for their targeted delivery, minimized side effects, and enhanced therapeutic outcomes. However, the translation of BDSs from research settings to clinical applications is fraught with challenges, including reproducibility concerns, physiological stability, and rigorous efficacy and safety evaluations. Furthermore, the innovative nature of BDSs demands a reevaluation and evolution of existing regulatory and ethical frameworks. This review provides an overview of BDSs, delve into the multifaceted translational challenges and present emerging solutions, underscored by real-world case studies. Emphasizing the potential of BDSs to redefine healthcare, we advocate for sustained interdisciplinary collaboration and research. As our understanding of biological systems deepens, the future of BDSs in clinical translation appears promising, with a focus on personalized medicine and refined patient-specific delivery systems.

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Section: Stability and Longevitymentioning

confidence: 99%

Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems

Wang,

et al. 2023

Preprint

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“…Benefiting from hydrophobic interaction-derived self-assembly, pH-sensitive Dox prodrug has been loaded by HSA, which has been shown to enable comparable antitumor efficacy and reduced cardiotoxicity versus free Dox . In addition, other drugs such as curcumin, , piceatannol, and methotrexate, with the aid of BSA carrier, also achieved higher cytotoxicity on tumor cells as compared with an equivalent dose of free one.…”

Section: Serum Albumin Engineered Nanomedicine For Cancer Treatmentmentioning

confidence: 99%

Protein-Based Nanomedicine for Therapeutic Benefits of Cancer

Zhang

Song

et al. 2021

ACS Nano

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Proteins, a type of natural biopolymer that possess many prominent merits, have been widely utilized to engineer nanomedicine for fighting against cancer. Motivated by their ever-increasing attention in the scientific community, this review aims to provide a comprehensive showcase on the current landscape of protein-based nanomedicine for cancer therapy. On the basis of role differences of proteins in nanomedicine, protein-based nanomedicine engineered with protein therapeutics, protein carriers, enzymes, and composite proteins is introduced. The cancer therapeutic benefits of the protein-based nanomedicine are also discussed, including small-molecular therapeutics-mediated therapy, macromolecular therapeutics-mediated therapy, radiation-mediated therapy, reactive oxygen species-mediated therapy, and thermal effect-mediated therapy. Lastly, future developments and potential challenges of protein-based nanomedicine are elucidated toward clinical translation. It is believed that protein-based nanomedicine will play a vital role in the battle against cancer. We hope that this review will inspire extensive research interests from diverse disciplines to further push the developments of protein-based nanomedicine in the biomedical frontier, contributing to ever-greater medical advances.

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Harnessing the Power of Nanomaterials to Alleviate Tumor Hypoxia in Favor of Cancer Therapy

Rashidzadeh

Mozafari

Ghaffarlou

et al. 2022

Harnessing Materials for X-Ray Based Cancer Therapy and Imaging

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Correction: Aljabali, A.A.A.; et al. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer via down Regulation of Nuclear p65 and HIF-1α. Cancers 2020, 12, 113

Abstract: The authors wish to make the following corrections to this paper [...]

Cited by 10 publications

References 1 publication

Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems

Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems

Protein-Based Nanomedicine for Therapeutic Benefits of Cancer

Harnessing the Power of Nanomaterials to Alleviate Tumor Hypoxia in Favor of Cancer Therapy

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