Correction: Amino acids regulate mTORC1 by an obligate two-step mechanism.

Abstract

In the originally published Fig. 1A, the immunoblots for total S6K were an inadvertent copy of the S6K immunoblots in Fig. 2A. The mistake was caused by confusion over file names during creation of the figure. This error has now been corrected. The bar graphs in the original Fig. 1, B and C, are based on quantitation of multiple blots and are correct as shown. This correction does not affect the results or conclusions of this work.

d-Serine Mediates Cellular Proliferation for Kidney Remodeling

“…Because genetic ablation of either p18 or Rheb was sufficient to suppress D-serine-dependent mTOR activation, D-serine activates mTORC1 through signals from both L-amino acids and PI3K/Rheb. The combination of amino acids is necessary for the full activation of mTORC1 (39), and D-serine is likely to assist mTROC1 activation as a key constituent of amino acids.…”