Correction. An Approach toward the Complete FAB Analysis of Enzymic Digests of Peptides and Proteins

An investigation of secondary ion yield enhancement using Bin2+ (n=1, 3, 5) primary ions

“…and is due matrix effects [41]. However, it is not clear why suppression of certain secondary ions is occurring in these experiments.…”

Combined high resolution chromatographic techniques (FPLC and HPLC) and mass spectrometry-based identification of peptides and proteins in Grana Padano cheese

“…The mass signaIs shifted according to the mass value of the N-terminal residue and this procedure repeated once or twice allowed to identify unambiguously the peptides. Since a partial suppression of the signaIs taking place in FAB analysis (Naylor et al, 1986), having as upper detection limit about 3000 Da, ES/MS was used, especially for large peptides and proteins. These techniques were of utmost importance for identifying cheese protein and peptides characterized by a microheterogeneity such as the discrete phosphorylation and the simultaneous presence of closely related different!y long peptides.…”

Charge derivatization of peptides for analysis by mass spectrometry

“…Several types of derivatives were developed to improve the detection limits of peptide analytes. Some of these derivatives contained nonpolar functionalities to increase the surface activities of peptides during analysis by FAB and LSIMS (Falick & Maltby, 1989;Ligon, 1986;Naylor et al, 1986). Other derivatives generated preformed ions, which increased ionization efficiencies of many analytes during analysis by desorption/ionization techniques (Busch et al, 1982).…”