Correction: An injectable hyaluronic acid/PEG hydrogel for cartilage tissue engineering formed by integrating enzymatic crosslinking and Diels–Alder “click chemistry”

Yu, Feng Lin; Cao, Xiaodong; Li, Yuli; Zeng, Lei; Yuan, Bo; Chen, Xiaofeng

doi:10.1039/c8py90106f

Cited by 3 publications

(3 citation statements)

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“…These hybrid polymer-based hydrogels, combining the potential chondrogenic tunable characteristics of both synthetic and natural polymers, can be designed to mimic key aspects of the native environment while precisely adjusting the hydrogel's mechanical, chemical and degradation properties 35 , 105 . For example, Yu et al fabricated two HA/PEG-based injectable hydrogels, both of which possess good mechanical properties and short gelation times, and the cells encapsulated in the hydrogels exhibit high metabolic viability and proliferation, thus indicating that both hydrogels have great potential in cartilage tissue engineering 39 , 106 . Additionally, Fu et al have prepared a novel injectable hydrogel that responds to thermal stimuli and comprises three components (triblock PEG-PCL-PEG copolymer, collagen, and nanohydroxyapatite) 107 .…”

Section: Design Of Injectable Hydrogelsmentioning

confidence: 99%

Exquisite design of injectable Hydrogels in Cartilage Repair

Chen

Deng

et al. 2020

Theranostics

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Cartilage damage is still a threat to human beings, yet there is currently no treatment available to fully restore the function of cartilage. Recently, due to their unique structures and properties, injectable hydrogels have been widely studied and have exhibited high potential for applications in therapeutic areas, especially in cartilage repair. In this review, we briefly introduce the properties of cartilage, some articular cartilage injuries, and now available treatment strategies. Afterwards, we propose the functional and fundamental requirements of injectable hydrogels in cartilage tissue engineering, as well as the main advantages of injectable hydrogels as a therapy for cartilage damage, including strong plasticity and excellent biocompatibility. Moreover, we comprehensively summarize the polymers, cells, and bioactive molecules regularly used in the fabrication of injectable hydrogels, with two kinds of gelation, i.e., physical and chemical crosslinking, which ensure the excellent design of injectable hydrogels for cartilage repair. We also include novel hybrid injectable hydrogels combined with nanoparticles. Finally, we conclude with the advances of this clinical application and the challenges of injectable hydrogels used in cartilage repair.

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Section: Design Of Injectable Hydrogelsmentioning

confidence: 99%

Exquisite design of injectable Hydrogels in Cartilage Repair

Chen

Deng

et al. 2020

Theranostics

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“…In addition to high coupling efficiency, DMTMM also has the advantages of easy removal of by‐products, good stability in water, selectively, and high reactivity in some cases in the aqueous solution 15,19,20 . The use of DMTMM for bioconjugations has been reported at both alkaline and acidic pH 20–24 . In recent years, the DMTMM‐mediated coupling for macromolecules has gradually increased, especially for the functional modification of hyaluronic acid 15,19,24–26 .…”

Section: Introductionmentioning

confidence: 99%

“…15,19,20 The use of DMTMM for bioconjugations has been reported at both alkaline and acidic pH. [20][21][22][23][24] In recent years, the DMTMM-mediated coupling for macromolecules has gradually increased, especially for the functional modification of hyaluronic acid. 15,19,[24][25][26] However, there are almost no reported studies have employed DMTMM for the amidation of CS so far.…”

Section: Introductionmentioning

confidence: 99%

DMTMM‐mediated grafting reaction of glucuronic acid on chitosan

Ye²,

Gong³

et al. 2022

J of Applied Polymer Sci

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Compared with traditional conjugates 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS), 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) is an emerging biological coupling reagent and has been used in the amidation of hyaluronic acid. In this paper, DMTMM was used to achieve the amidation of chitosan (CS) with glucuronic acid (GA) in an aqueous medium to generate a GA-CS derivative. The grafting efficacy was preliminarily compared with the EDC/NHS-mediated reaction. As a result, the substitution degree of 17.6% for DMTMM-mediated grafting and 13.1% for EDC/NHS chemistry indicated that DMTMM-mediated synthesis of GA-CS appeared to be more efficient. The reaction kinetics experiments showed that GA-CS derivative with a degree of substitution up to about 26.1% was obtained using equal molar ratios of DMTMM and GA exceeding CS at room temperature. These results indicate that employing DMTMM as a coupling agent is a feasible and promising strategy for the amidation modification of chitosan.

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