Correction: Anemia in tuberculosis cases: A biomarker of severity?

Mendonça, Edson Beyker de; Schmaltz, Carolina AranaStanis; Sant’Anna, Flávia Marinho; Vizzoni, Alexandre Gomes; Mendes-de-Almeida, Daniela P.; Oliveira, Raquel; Rolla, Valéria Cavalcanti

doi:10.1371/journal.pone.0249545

Cited by 3 publications

(3 citation statements)

References 1 publication

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“…In Ethiopia, anemic TB patients had a 3.23 times higher risk of malnutrition than non-anemic TB patients (9). Iron deficiency is another major cause of TB anemia (12,13).…”

Section: Impact Of Anemia On Prognosis In Tuberculosis Patientsmentioning

confidence: 99%

“…The lungs were divided into 6 regions, with upper, middle, and lower zones on the left and right sides, to observe the infection zones in the lungs (11). The rate of cavity closure was calculated based on cavity reduction and closure status (12). The presence of pleural effusion, if any, and the effusion improvement were learned from previous CT reports.…”

Section: Computed Tomography (Ct) Findingsmentioning

confidence: 99%

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Impact of anemia on prognosis in tuberculosis patients

Luo¹,

Liu²,

Wu³

et al. 2022

Ann Transl Med

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Background: Anemia is one of the risk factors for tuberculosis (TB), and more than 90% of TB patients suffer from anemia. The majority tuberculosis patients who had poor prognosis experienced anemia during the course of treatment. The objective of our study is to analyse the influences of anemia on the prognosis of tuberculosis patients in terms of pulmonary M. tuberculosis loads, lung pathology, and clinical factors. Methods:In this retrospective cohort study, 155 TB patients in Shanghai were divided into the anemiatuberculosis (A-TB) group and non-anemia-tuberculosis (NA-TB) group. We analysed bacteria counts in sputum smear and sputum smear conversion time between two groups. We evaluated the pulmonary pathology of cavity and effusion in A-TB patients. Logistic regression analysis was performed to explore the potential correlations of anemia with sputum bacterial load and pulmonary pathology. We compared clinical factors including the immune factors and inflammatory cells.Results: Compared with the NA-TB (n=89) group, the A-TB group (n=66) had poorer improvement of lung injury in terms of cavity closure (4.7±3.59 vs. 10.56±7.42; P=0.036) and fluid improvement [4 (30.77%) vs. 12 (92.31%); P=0.001] during conventional treatment. At the start of treatment, the immune factors complement 4 (C4) [0.25 (0.19, 0.295) vs. 0.3086±0.076; P=0.006] and C-reactive protein (CRP) [3.2 (3.2, 21.5) vs. 19.5 (6.25, 78.35); P=0.016] were significantly higher in A-TB with NA-TB. During the course of treatment, the gradual decrease in the absolute number of lymphocytes (LYM#) (P=0.0012, r=−0.3400) and the gradual increase in the absolute number of monocytes (MONO#) (P=0.0050, r=0.2968), the absolute number of basophils (BASO#) (P=0.0213, r=0.2451), the red blood cell distribution width-coefficient (RDW-CV) (P=0.0136, r=0.2651), suggesting poor prognosis in anemic TB patients.Conclusions: Anemia is a risk factor for lung injury in TB patients. Inflammatory factors and inflammatory cells are increased during treatment in A-TB patients.

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“…In Ethiopia, anemic TB patients had a 3.23 times higher risk of malnutrition than non-anemic TB patients (9). Iron deficiency is another major cause of TB anemia (12,13).…”

Section: Impact Of Anemia On Prognosis In Tuberculosis Patientsmentioning

confidence: 99%

Section: Computed Tomography (Ct) Findingsmentioning

confidence: 99%

Impact of anemia on prognosis in tuberculosis patients

Luo¹,

Liu²,

Wu³

et al. 2022

Ann Transl Med

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“…6,7 Adanya disregulasi sistem imun mengakibatkan peningkatan sitokin proinflamasi yang menyebabkan penurunan sel progenitor eritroid yang menyebabkan anemia akibat adanya gangguan pembentukan eritrosit. 8 Selain leukosit dan eritrosit, trombosit juga berkorelasi dengan infeksi TBC. Trombositosis ditemukan pada TBC dan berkorelasi dengan beratnya penyakit.…”

Section: Pendahuluanunclassified

Perbedaan Gambaran Pemeriksaan Darah Lengkap Pre Dan Pasca Terapi Tuberkulosis Fase Intensif Pada Pediatri

Iskandar,

Olivianto,

Syahfitri

et al. 2024

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Tuberculosis (TBC) merupakan penyakit kronis yang banyak ditemui di Indonesia. Terapi yang diperlukan untuk mengeradikasi bakteri penyebab TBC (Mycobacterium tuberculosis) membutuhkan waktu setidaknya 6 bulan, yaitu 2 bulan fase intensif diikuti 4 bulan fase lanjutan. Selama ini, monitoring hasil terapi dilakukan setelah fase intensif dengan melakukan pemeriksaan mikrobiologis. Namun, pemeriksaan mikrobiologis kurang sensitif dan lebih sulit dilakukan khususnya pada anak sehingga diperlukan pemeriksaan lain yang lebih sederhana. Penelitian ini bertujuan untuk mengetahui profil hematologi yaitu profil eritrosit, leukosit, dan trombosit pre dan pasca terapi fase intensif obat antituberkulosis pada anak. Penelitian observasional analitik berdesain kohort prospektif dilakukan terhadap 90 pasien anak. dengan TBC paru maupun ekstra paru di Poli Kesehatan Anak RSUD Dr. Saiful Anwar (RSSA) Malang pada Februari hingga Desember 2018. Hasil penelitian menggambarkan bahwa pada pasca terapi, jumlah leukosit (p = 0,036), neutrofil (p = 0,020), trombosit (p = 0,008), dan PCT (p = 0,015) lebih rendah namun jumlah limfosit (p = 0,037) lebih tinggi; sedangkan monosit, hemoglobin, indeks eritrosit, RDW, dan MPV tidak berbeda bermakna. Sekalipun demikian, jumlah leukosit, neutrofil, trombosit, plateletcrit (PCT) yang menurun serta jumlah limfosit yang lebih tinggi tidak berkorelasi dengan respons terapi pada TBC anak. Kesimpulan penelitian ini adalah terdapat penurunan leukosit, neutrofil, trombosit, PCT, dan peningkatan limfosit akan tetapi tidak berhubungan dengan respons pengobatan.

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The Relationship Between Natural Resistance –Associated Macrophage Protein 1 (NRAMP-1) Levels and Hb and Body Mass Index (BMI) in Tuberculosis Lymphadenitis Patients

Djannah,

Setijo Rahaju,

Nasrum Massi

et al. 2024

RJPT

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Backgrounds: Tuberculosis lymphadenitis (LnTB) is the most common extrapulmonary tuberculosis (EPTB). The NRAMP-1 gene is located in macrophages which functions to secrete iron needed by MTB to live. Enzyme-linked immunosorbent assay (Elisa) is a serological test commonly used in various immunology laboratories. Objectives: This study aimed to investigate the relationship of NRAMP-1 levels with Hb and BMI in tuberculosis lymphadenitis patients. Method: This study is a descriptive cross-sectional carried out from January to September 2021 on 50 LnTB patients. Blood was taken before treatment and then an ELISA examination was performed to determine NRAMP-1 levels, as well as an Hb examination. Nutritional status was determined by body mass index (BMI) assessment. Results: Of the 78 respondents, 34.6% are male and 65.4% are female. The mean age of the respondents in this study is 26.89. Histopathologically, it was found that 56.4% are well-organized granulomas and the respondent patients are mostly from Mataram with a percentage of 30.7%. The mean nodule complaint is 3.0064 cm. The mean NRAMP-1 level is 256.88, the mean Hb is 12.05, and the mean BMI is 20.31. After the spearman-rho test, it was found that the relationship between NRAMP-1 levels and Hb is p=0.018 and the relationship between NRAMP-1 levels and BMI is p=0.242. Conclusion: There is a relationship between NRAMP-1 levels and Hb. However, there is no significant relationship between NRAMP-1 levels and BMI.

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Correction: Anemia in tuberculosis cases: A biomarker of severity?

Cited by 3 publications

References 1 publication

Impact of anemia on prognosis in tuberculosis patients

Impact of anemia on prognosis in tuberculosis patients

Perbedaan Gambaran Pemeriksaan Darah Lengkap Pre Dan Pasca Terapi Tuberkulosis Fase Intensif Pada Pediatri

The Relationship Between Natural Resistance –Associated Macrophage Protein 1 (NRAMP-1) Levels and Hb and Body Mass Index (BMI) in Tuberculosis Lymphadenitis Patients

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