Correction by the skin-to-chest wall distance in near-infrared spectroscopy and assessment of breast cancer responses to neoadjuvant chemotherapy

Asano, Yuko; Yoshizawa, Noriko; Ueda, Yoshihiro; Yoshimoto, Kenji; Mimura, Takashi; Ohmae, Etsuko; Wada, Hiroko; Ueda, Shigeto; Sendo, Toshiaki; Ogura, Hironao; Shiiya, Norihiko; Sakahara, Harumi

doi:10.1007/s10043-018-0486-4

Cited by 1 publication

(2 citation statements)

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“…used in our previous studies. [9][10][11][12] The TRS-21-6W system uses the time-correlated single-photon counting (TCSPC) method to acquire the time response profile of pulsed laser light penetrating the target tissue. The system includes two light source units, each containing three laser diodes (762, 802, and 838 nm for the first unit; 908, 936, and 976 nm for the second unit) that emit a light pulse with a full width at half maximum of ~100 to ~200 ps at a repetition rate of 5 MHz (custom-designed, Hamamatsu Photonics K.K.).…”

Section: Td-dos and Us Measurementsmentioning

confidence: 99%

“…8 We previously reported the possibility of combining TD-DOS with ultrasonography (US) by performing reflectance measurements with a three-wavelength TD-DOS system capable of determining the tissue concentration of oxyhemoglobin (O 2 Hb), deoxyhemoglobin (HHb), total hemoglobin (tHb), and tissue oxygen saturation. [9][10][11][12] We examined the relationships between these parameters and structural information for breast tissue. As a result, we found that tHb can be used as a biomarker to evaluate breast cancer, although the effect of the chest wall must be considered.…”

Section: Introductionmentioning

confidence: 99%

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Water and lipid content of breast tissue measured by six-wavelength time-domain diffuse optical spectroscopy

et al. 2022

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Significance: The water and lipid content of normal breast tissue showed mammary gland characteristics with less influence from the chest wall using six-wavelength time-domain diffuse optical spectroscopy (TD-DOS) in a reflectance geometry.Aim: To determine the depth sensitivity of a six-wavelength TD-DOS system and evaluate whether the optical parameters in normal breast tissue can distinguish dense breasts from nondense breasts.Approach: Measurements were performed in normal breast tissue of 37 breast cancer patients. We employed a six-wavelength TD-DOS system to measure the water and lipid content in addition to the hemoglobin concentration. The breast density in mammography and optical parameters were then compared. Results:The depth sensitivity of the system for water and lipid content was estimated to be ∼15 mm. Our findings suggest that the influence of the chest wall on the water content is weaker than that on the total hemoglobin concentration. In data with evaluation conditions, the water content was significantly higher (p < 0.001) and the lipid content was significantly lower (p < 0.001) in dense breast tissue. The water and lipid content exhibited a high sensitivity and specificity to distinguish dense from non-dense breasts in receiver-operating-characteristic curve analysis.Conclusions: With less influence from the chest wall, the water and lipid content of normal breast tissue measured by a reflectance six-wavelength TD-DOS system, together with ultrasonography, can be applied to distinguish dense from non-dense breasts.

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Section: Td-dos and Us Measurementsmentioning

confidence: 99%