Correction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3

He, Chuan-Hua; Park, Jin Wook; Lee, Jae Hyun; Kamle, Suchitra; Ma, Bing; Akosman, Bedia; Cotez, Roberto; Chen, Emily; Zhou, Y.; Herzog, Erica L.; Ryu, C. Hyun; Peng, Xueyan; Rosas, Iván O.; Poli, Sergio; Bostwick, Carol Feghali; Choi, Augustine M.K.; Elias, Jack A.; Lee, Chang-Min

doi:10.26508/lsa.202302065

Cited by 1 publication

(3 citation statements)

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“…Chitinases, including Chitinase 1 (CHIT1), chitinase 3-like-1 (CHI3L1) are implicated in the regulation of fibrosis, a pathological condition characterized by the excessive accumulation of ECM proteins leading to scarring and organ damage ( 94 , 95 ). Lee et al.…”

Section: Implant Materials and Inflammationmentioning

confidence: 99%

“…Lee et al. demonstrated that CHIT1 is required for the development of pulmonary fibrosis, and TGF-β1 plays a critical role in this process ( 94 ). They used wild type and CHIT1 null mutant mice, and demonstrated that TGF-β1 stimulated the production of ECM proteins such as fibronectin and type 1 collagen in a CHIT1 dependent manner.…”

Section: Implant Materials and Inflammationmentioning

confidence: 99%

“…They used wild type and CHIT1 null mutant mice, and demonstrated that TGF-β1 stimulated the production of ECM proteins such as fibronectin and type 1 collagen in a CHIT1 dependent manner. Furthermore, the fibrotic responses were exaggerated in mice lungs in which both CHIT1 and TGF-β1 were expressed simultaneously compared to mice in which each factors were expressed individually ( 94 ). CHI3L1 has been implicated in fibrosis and inflammation, particularly in diseases characterized by tissue remodeling.…”

Section: Implant Materials and Inflammationmentioning

confidence: 99%

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Modelling of macrophage responses to biomaterials in vitro: state-of-the-art and the need for the improvement

Piatnitskaia,

Rafikova,

Bilyalov

et al. 2024

Front. Immunol.

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The increasing use of medical implants in various areas of medicine, particularly in orthopedic surgery, oncology, cardiology and dentistry, displayed the limitations in long-term integration of available biomaterials. The effective functioning and successful integration of implants requires not only technical excellence of materials but also consideration of the dynamics of biomaterial interaction with the immune system throughout the entire duration of implant use. The acute as well as long-term decisions about the efficiency of implant integration are done by local resident tissue macrophages and monocyte-derived macrophages that start to be recruited during tissue damage, when implant is installed, and are continuously recruited during the healing phase. Our review summarized the knowledge about the currently used macrophages-based in vitro cells system that include murine and human cells lines and primary ex vivo differentiated macrophages. We provided the information about most frequently examined biomarkers for acute inflammation, chronic inflammation, foreign body response and fibrosis, indicating the benefits and limitations of the model systems. Particular attention is given to the scavenging function of macrophages that controls dynamic composition of peri-implant microenvironment and ensures timely clearance of microorganisms, cytokines, metabolites, extracellular matrix components, dying cells as well as implant debris. We outline the perspective for the application of 3D systems for modelling implant interaction with the immune system in human tissue-specific microenvironment avoiding animal experimentation.

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Section: Implant Materials and Inflammationmentioning

confidence: 99%

Section: Implant Materials and Inflammationmentioning

confidence: 99%

Section: Implant Materials and Inflammationmentioning

confidence: 99%

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