Correction: Clustering of Ca2+ transients in interstitial cells of Cajal defines slow wave duration

Abstract

All tissues were perfused and maintained with KRB solution containing (mmol/liter): 120.35 NaCl, 15.5 NaHCO 3 , 5.9 KCl, 1.2 MgCl 2 , 1.2 NaH 2 PO 4 , 2.5 CaCl 2 , and 11.5 glucose. The KRB solution warmed to a physiological temperature of 37 ± 0.2°C and bubbled with a mixture of 97% O 2 -3% CO 2 . For experiments using external solutions with zero [Ca 2+ ] o , CaCl 2 was omitted and 1 mM EGTA was added to the solution. NNC 55-0396 and TTA-A2 were purchased from Alomone Labs, nicardipine was purchased from Sigma-Aldrich, thapsigargin, isradipine, and ryanodine were purchased from Tocris Bioscience, and multiple batches of Xestospongin C (XeC) were purchased from Cayman Chemical.All versions of this article have been corrected. Correction

Transcriptome analysis of PDGFRα+ cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFRα+ cell hyperplasia

“…PαC mediate inhibitory purinergic neurotransmission in GI smooth muscles [ 10 , 11 ]. In general, due to the coupling of Ca 2+ -activated Cl - channels to Ca 2+ release events in ICC [ 12 – 14 ] and coupling of SK3 channels to Ca 2+ -release events in PαC [ 11 , 15 , 16 ], stimuli initiating Ca 2+ release in these cells will have opposite effects on the excitability of the SIP syncytium: Ca 2+ mobilization in ICC and PαC will exert excitatory and inhibitory effects on the SMC component of the SIP syncytium.…”

Ca2+signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the colon

“…T-type Ca 2+ channels are an important source for Ca 2+ entry in pacemaker ICC of the small intestine[56][57][58]. T-type channel antagonists (Ni 2+ and mibefradil) reduced the rate-of-rise of the upstroke component of the slow waves and higher concentrations attenuated slow wave activity[56,59,60].…”