Correction: Corrigendum: Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices

Mierke, Claudia Tanja; Fischer, Tony; Puder, Stefanie; Kunschmann, Tom; Soetje, Birga; Ziegler, Wolfgang

doi:10.1038/srep46435

Cited by 5 publications

(4 citation statements)

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“…Interaction between FAK and PI3 kinase induces effector Rac, which regulates cortical actin and lamellipodia in cell migration 13. Extracellular signal‐regulated kinase (ERK)/mitogen‐activated protein (MAP) kinase is another downstream signaling pathway of FAK, as active ERK increases actin–myosin contraction of cells 14.…”

Section: Resultsmentioning

confidence: 99%

Development of Biocompatible HA Hydrogels Embedded with a New Synthetic Peptide Promoting Cellular Migration for Advanced Wound Care Management

et al. 2018

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In the past few years, there have been many efforts underway to develop effective wound healing treatments for traumatic injuries. In particular, wound‐healing peptides (WHPs) and peptide‐grafted dressings hold great promise for novel therapeutic strategies for wound management. This study reports a topical formulation of a new synthetic WHP (REGRT, REG) embedded in a hyaluronic acid (HA)‐based hydrogel dressing for the enhancement of acute excisional wound repair. The copper‐free click chemistry is utilized to form biocompatible HA hydrogels by cross‐linking dibenzocyclooctyl‐functionalized HA with 4‐arm poly(ethylene glycol) (PEG) azide. The HA hydrogels are grafted with the REG peptide, a functional derivative of erythroid differentiation regulator1, displaying potent cell motility‐stimulating ability, thus sustainably releasing physiologically active peptides for a prolonged period. Combined with the traditional wound healing benefits of HA, the HA hydrogel embedded REG (REG‐HAgel) accelerates re‐epithelialization in skin wound healing, particularly by promoting migration of fibroblasts, keratinocytes, and endothelial cells. REG‐HAgels improve not only rate, but quality of wound healing with higher collagen deposition and more microvascular formation while being nontoxic. The peptide‐grafted HA hydrogel system can be considered as a promising new wound dressing formulation strategy for the treatment of different types of wounds with combinations of various natural and synthetic WHPs.

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Section: Resultsmentioning

confidence: 99%

Development of Biocompatible HA Hydrogels Embedded with a New Synthetic Peptide Promoting Cellular Migration for Advanced Wound Care Management

et al. 2018

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“…A fibroblast’s primary function is the maintenance of the extracellular matrix ( D’Urso and Kurniawan, 2020 ) through the strategic deposition and digestion of tissue. A key mechanism by which fibroblasts communicate with, migrate through, deform, and are deformed by their environment is through focal adhesions ( Mierke et al, 2017 ; Stutchbury et al, 2017 ; Tschumperlin et al, 2018 ). It is known that fibroblasts are able to react in response to a material’s stiffness by depositing more material, and it is hypothesized that the cell is able to measure local tissue stiffness by active contraction ( Engler et al, 2006 ).…”

Section: Discussionmentioning

confidence: 99%

Elucidating the interaction between stretch and stiffness using an agent-based spring network model of progressive pulmonary fibrosis

Hall,

Bates,

Krishnan

et al. 2024

Front. Netw. Physiol.

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Pulmonary fibrosis is a deadly disease that involves the dysregulation of fibroblasts and myofibroblasts, which are mechanosensitive. Previous computational models have succeeded in modeling stiffness-mediated fibroblasts behaviors; however, these models have neglected to consider stretch-mediated behaviors, especially stretch-sensitive channels and the stretch-mediated release of latent TGF-β. Here, we develop and explore an agent-based model and spring network model hybrid that is capable of recapitulating both stiffness and stretch. Using the model, we evaluate the role of mechanical signaling in homeostasis and disease progression during self-healing and fibrosis, respectively. We develop the model such that there is a fibrotic threshold near which the network tends towards instability and fibrosis or below which the network tends to heal. The healing response is due to the stretch signal, whereas the fibrotic response occurs when the stiffness signal overpowers the stretch signal, creating a positive feedback loop. We also find that by changing the proportional weights of the stretch and stiffness signals, we observe heterogeneity in pathological network structure similar to that seen in human IPF tissue. The system also shows emergent behavior and bifurcations: whether the network will heal or turn fibrotic depends on the initial network organization of the damage, clearly demonstrating structure’s pivotal role in healing or fibrosis of the overall network. In summary, these results strongly suggest that the mechanical signaling present in the lungs combined with network effects contribute to both homeostasis and disease progression.

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“…When addressing the mechanical properties of cells without the impact of cell adhesion, improved cell deformation/stretching biophysical techniques can be used, compromising an optical cell stretcher (Guck et al, 2005 ; Mierke et al, 2017 , 2020 ; Mierke, 2019b ) and microfluidics-based cell stretcher that represents a channel confinement for directional flowing or migrating cells (Huang et al, 2020 ; Yao et al, 2020 ).…”

Section: Development Establishment and Advancement Of Biophysical Techniquesmentioning

confidence: 99%

“…Due to the vastly high number of molecules that function in cell adhesion under physiological and pathological processes, the agglomeration of proteins within focal adhesion has been termed cancer cellular adhesome to discriminate them from randomly distributed surrounding proteins (Maziveyi and Alahari, 2017 ). The contributing proteins of the adhesome can be divided into four different branches of the basic adhesion system which includes the Talin-Vinculin (Mierke et al, 2008a , 2010 ; Golji et al, 2011 ; Wang et al, 2019 ; Boujemaa-Paterski et al, 2020 ), FAK-Paxillin (Hu et al, 2015 ; Mierke et al, 2017 ; Ripamonti et al, 2021 ), α-Actinin-Zyxin-VASP (Oldenburg et al, 2015 ), and ILK-PINCH-Kindlin biochemical signal transduction pathways (Honda et al, 2013 ; Horton et al, 2015 ; Kunschmann et al, 2017 ). All of them represent critical pathways or mechanosensory systems to respond to changes in the mechanical homoestatic stage of cells.…”

Section: Introductionmentioning

confidence: 99%

The Pertinent Role of Cell and Matrix Mechanics in Cell Adhesion and Migration

Mierke

2021

Front. Cell Dev. Biol.

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Correction: Corrigendum: Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices

Cited by 5 publications

References 0 publications

Development of Biocompatible HA Hydrogels Embedded with a New Synthetic Peptide Promoting Cellular Migration for Advanced Wound Care Management

Development of Biocompatible HA Hydrogels Embedded with a New Synthetic Peptide Promoting Cellular Migration for Advanced Wound Care Management

Elucidating the interaction between stretch and stiffness using an agent-based spring network model of progressive pulmonary fibrosis

The Pertinent Role of Cell and Matrix Mechanics in Cell Adhesion and Migration

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