Correction: Corrigendum: Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice

si-young, cho; Kim, Juewon; Lee, Ji Hae; Sim, Ji Hyun; Cho, Dong−Hyun; Bae, Il-Hong; Lee, Hyunbok; Seol, Min A.; Shin, Hyun Mu; Kim, Taejoo; Kim, Dae-Yong; Lee, Su-Hyung; Shin, Song Seok; Im, Sungbin; Kim, Hang Rae

doi:10.1038/srep41667

Cited by 2 publications

(1 citation statement)

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“…Similar to silymarin, flaxseed lignan pretreatment also increased the richness and evenness of microbial diversity. Plant lignan has the ability to modulate the composition of intestinal microbes, and in turn, these microbes break down lignan to release bioactive metabolites [ 43 ]. As expected, the unabsorbed lignan was utilized as substrate by enterolactone-producing bacterial species, thus improving the gut microbiota diversity.…”

Section: Discussionmentioning

confidence: 99%

Flaxseed Lignan Alleviates the Paracetamol-Induced Hepatotoxicity Associated with Regulation of Gut Microbiota and Serum Metabolome

Ren,

Xu,

Qiao

et al. 2024

Nutrients

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This study examined the protective effect of flaxseed lignans on liver damage caused by an overdose of paracetamol (PAM). The findings demonstrated that administering 800 mg/kg/d flaxseed lignan prior to PAM significantly decreased the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBi) levels, while it increased liver superoxide dismutase (SOD) and glutathione (GSH) levels in mice. Flaxseed lignan renovated the gut microbiota dysbiosis induced by PAM by promoting the proliferation of sulfonolipid (SL) producing bacteria such as Alistipes and lignan-deglycosolating bacteria such as Ruminococcus while inhibiting the growth of opportunistic pathogen bacteria such as Acinetobacter and Clostridium. Furthermore, flaxseed lignan modulated the serum metabolomic profile after PAM administration, specifically in the taurine and hypotaurine metabolism, phenylalanine metabolism, and pyrimidine metabolism. The study identified eight potential biomarkers, including enterolactone, cervonyl carnitine, acutilobin, and PC (20:3(5Z, 8Z, 11Z)/20:0). Overall, the results suggest that flaxseed lignan can alleviate PAM-induced hepatotoxicity and may be beneficial in preventing drug-induced microbiome and metabolomic disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Flaxseed Lignan Alleviates the Paracetamol-Induced Hepatotoxicity Associated with Regulation of Gut Microbiota and Serum Metabolome

Ren,

Xu,

Qiao

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

The effect of abnormal lipid metabolism on immunosenescence of the colonic lamina propria in mice of different ages

Cong,

Zhang,

et al. 2024

Immunology Letters

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Correction: Corrigendum: Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice

Abstract: The original version of this Article contained an error in the spelling of Sin-Hyeog Im, which was incorrectly given as Sin-Hyeog Lm. This has now been corrected in the PDF and HTML versions of this Article.

Cited by 2 publications

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Flaxseed Lignan Alleviates the Paracetamol-Induced Hepatotoxicity Associated with Regulation of Gut Microbiota and Serum Metabolome

Flaxseed Lignan Alleviates the Paracetamol-Induced Hepatotoxicity Associated with Regulation of Gut Microbiota and Serum Metabolome

The effect of abnormal lipid metabolism on immunosenescence of the colonic lamina propria in mice of different ages

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