Correction: Exploration of surgical blood pressure management and expected motor recovery in individuals with traumatic spinal cord injury

Ehsanian, Reza; Haefeli, Jenny; Quach, Nhung; Kosarchuk, Jacob; Torres, Dolores; Stück, Ellen D.; Endo, Jessica; Crew, James; Dirlikov, Benjamin; Bresnahan, Jacqueline C.; Beattie, Michael S.; Ferguson, Adam R.; McKenna, Stephen L.

doi:10.1038/s41393-019-0400-3

Cited by 10 publications

(1 citation statement)

References 33 publications

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“…Blood pressure augmentation, on the other hand, prompts improved postoperative neurological outcomes, since it allows for higher spine resilience to an eventual decrease in blood supply throughout surgery 28. Data supporting adequate pressure ranges are largely limited by confounders and lack of comparative qualities,30,31 and there is a need for qualitative data with specific optimal MAP. Although the adult spinal cord is more resistant to hypoxic ischemic injury due to collateral supply and autoregulation mechanisms, patients with spinal cord stenosis are more vulnerable to injury and positional adverse effects due to mechanical compression leading to diminished perfusion 32.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Perioperative Approach to Complex Spine Deformity Management

Camargo

Abode-Iyamah²,

Shah³

et al. 2021

Clinical Spine Surgery: A Spine Publication

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Objective: Study perioperative strategies for optimizing neuroprotection in complex spine deformity correction surgery. Methods: We report the case of a patient with severe lumbar dextroscoliosis, thoracolumbar junction hyperkyphosis with a 40-degree Cobb angle levoconvex scoliosis who underwent spinal deformity correction with loss of neuromonitoring during surgery. We performed a literature review on perioperative management of complex spine deformity. Results: A 50-year-old man presented with lumbar pain and right L4 radiculopathy. Surgical intervention for deformity correction and decompression was indicated with T4−L4 posterior instrumentation L2/L3 and L3/L4 transforaminal lumbar interbody fusion. Surgery was aborted due to the loss of neuromonitoring. Postsurgery, the patient had left sensory deficit and the neurocritical care team clinically suspected and deduced the anatomic location of the spinal cord compression. Magnetic resonance imaging confirmed a T10−T11 hyperintensity suggestive of cord ischemia due to osteophyte compressing the spinal cord. The patient underwent a second corrective surgery with no intraoperative events and has no long-term neurological sequela. Conclusions: This case illustrates that a comprehensive perioperative approach and individualized risk factor assessment is useful in complex spine deformity surgery. Further research is needed to determine how this individualized comprehensive approach can lead to intraoperative and postoperative countermeasures that improved spine surgery outcomes. Level of Evidence: Level V.

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Section: Discussionmentioning

confidence: 99%

Comprehensive Perioperative Approach to Complex Spine Deformity Management

Camargo

Abode-Iyamah²,

Shah³

et al. 2021

Clinical Spine Surgery: A Spine Publication

View full text Add to dashboard Cite

show abstract

Excavating FAIR Data: the Case of the Multicenter Animal Spinal Cord Injury Study (MASCIS), Blood Pressure, and Neuro-Recovery

et al. 2021

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Meta-analyses suggest that the published literature represents only a small minority of the total data collected in biomedical research, with most becoming ‘dark data’ unreported in the literature. Dark data is due to publication bias toward novel results that confirm investigator hypotheses and omission of data that do not. Publication bias contributes to scientific irreproducibility and failures in bench-to-bedside translation. Sharing dark data by making it Findable, Accessible, Interoperable, and Reusable (FAIR) may reduce the burden of irreproducible science by increasing transparency and support data-driven discoveries beyond the lifecycle of the original study. We illustrate feasibility of dark data sharing by recovering original raw data from the Multicenter Animal Spinal Cord Injury Study (MASCIS), an NIH-funded multi-site preclinical drug trial conducted in the 1990s that tested efficacy of several therapies after a spinal cord injury (SCI). The original drug treatments did not produce clear positive results and MASCIS data were stored in boxes for more than two decades. The goal of the present study was to independently confirm published machine learning findings that perioperative blood pressure is a major predictor of SCI neuromotor outcome (Nielson et al., 2015). We recovered, digitized, and curated the data from 1125 rats from MASCIS. Analyses indicated that high perioperative blood pressure at the time of SCI is associated with poorer health and worse neuromotor outcomes in more severe SCI, whereas low perioperative blood pressure is associated with poorer health and worse neuromotor outcome in moderate SCI. These findings confirm and expand prior results that a narrow window of blood-pressure control optimizes outcome, and demonstrate the value of recovering dark data for assessing reproducibility of findings with implications for precision therapeutic approaches.

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Is Graphene Shortening the Path toward Spinal Cord Regeneration?

et al. 2022

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Along with the development of the next generation of biomedical platforms, the inclusion of graphene-based materials (GBMs) into therapeutics for spinal cord injury (SCI) has potential to nourish topmost neuroprotective and neuroregenerative strategies for enhancing neural structural and physiological recovery. In the context of SCI, contemplated as one of the most convoluted challenges of modern medicine, this review first provides an overview of its characteristics and pathophysiological features. Then, the most relevant ongoing clinical trials targeting SCI, including pharmaceutical, robotics/neuromodulation, and scaffolding approaches, are introduced and discussed in sequence with the most important insights brought by GBMs into each particular topic. The current role of these nanomaterials on restoring the spinal cord microenvironment after injury is critically contextualized, while proposing future concepts and desirable outputs for graphene-based technologies aiming to reach clinical significance for SCI.

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Correction: Exploration of surgical blood pressure management and expected motor recovery in individuals with traumatic spinal cord injury

Abstract: A correction to this paper has been published and can be accessed via a link at the top of the paper.

Cited by 10 publications

References 33 publications

Comprehensive Perioperative Approach to Complex Spine Deformity Management

Comprehensive Perioperative Approach to Complex Spine Deformity Management

Excavating FAIR Data: the Case of the Multicenter Animal Spinal Cord Injury Study (MASCIS), Blood Pressure, and Neuro-Recovery

Is Graphene Shortening the Path toward Spinal Cord Regeneration?

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