Correction for Shin et al., Histone Deacetylase Classes I and II Regulate Kaposi's Sarcoma-Associated Herpesvirus Reactivation

Shin, Hye Jin; DeCotiis, Jennifer; Giron, Mario; Palmeri, Diana; Lukac, David M.

doi:10.1128/jvi.00587-16

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“…Alternatively, KSHV reactivation from the latent state can be triggered by caspase 3-dependent apoptotic stress, in the absence of RTA activity [224,225]. KSHV can also chemically switch from latency to lytic replication by 12-Otetradecanoylphorbol-13-acetate (TPA), valproic acid (VPA), and sodium butyrate (NaB) [226,227]. Examples of oncogenic viral proteins in the lytic cycle include K1, K15, viral interleukin 6 (vIL-6), and viral G protein-coupled receptor (vGPCR).…”

Section: Kshv Lytic Lifecyclementioning

confidence: 99%

Cancers associated with human gammaherpesviruses

et al. 2021

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Epstein–Barr virus (EBV; human herpesvirus 4; HHV‐4) and Kaposi sarcoma‐associated herpesvirus (KSHV; human herpesvirus 8; HHV‐8) are human gammaherpesviruses that have oncogenic properties. EBV is a lymphocryptovirus, whereas HHV‐8/KSHV is a rhadinovirus. As lymphotropic viruses, EBV and KSHV are associated with several lymphoproliferative diseases or plasmacytic/plasmablastic neoplasms. Interestingly, these viruses can also infect epithelial cells causing carcinomas and, in the case of KSHV, endothelial cells, causing sarcoma. EBV is associated with Burkitt lymphoma, classic Hodgkin lymphoma, nasopharyngeal carcinoma, plasmablastic lymphoma, lymphomatoid granulomatosis, leiomyosarcoma, and subsets of diffuse large B‐cell lymphoma, post‐transplant lymphoproliferative disorder, and gastric carcinoma. KSHV is implicated in Kaposi sarcoma, primary effusion lymphoma, multicentric Castleman disease, and KSHV‐positive diffuse large B‐cell lymphoma. Pathogenesis by these two herpesviruses is intrinsically linked to viral proteins expressed during the lytic and latent lifecycles. This comprehensive review intends to provide an overview of the EBV and KSHV viral cycles, viral proteins that contribute to oncogenesis, and the current understanding of the pathogenesis and clinicopathology of their related neoplastic entities.

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