Correction: Grading of Atrophic Gastritis is Useful for Risk Stratification in Endoscopic Screening for Gastric Cancer

Kaji, Kyosuke; Hashiba, Atsushi; Uotani, Chika; Yamaguchi, Yasushi; Ueno, Toshio; Ohno, Kenji; Takabatake, Ichiro; Wakabayashi, Tokio; Doyama, Hisashi; Ninomiya, Itasu; Kiriyama, Masato; Ohyama, Shigekazu; Yoneshima, Manabu; Koyama, Nobu; Takeda, Yasuo

doi:10.14309/ajg.0000000000000206

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AG is a chronic disorder losing the oxyntic glands, which is characterized by lamina propria fibrosis or their replacement with pseudo-pyloric or IM [3]. Therefore, early supervision of AG could reduce the incidence of gastric cancer [4].…”

Section: Introductionmentioning

confidence: 99%

Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis patients without Helicobacter pylori infection: a case control study

Kong

Dang

et al. 2020

BMC Cancer

View full text Add to dashboard Cite

Background: Previous reports indicate that the methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism plays a role in gastric cancer. However, whether it influences the development and progression of atrophic gastritis remains ambiguous. We aimed to determine the possible relationship between MTHFR C677T polymorphism and the severity of atrophic gastritis. Methods: A total of 128 patients without Helicobacter pylori infection were included in the study. The severity of gastric atrophy was assessed by pathological diagnosis using OLGA and OLGIM Gastritis Staging System. MTHFR 677C > T genotyping was performed by digital fluorescence molecular hybridization. Categorical variables were analyzed by percentages using the χ 2 test. Results: In this study, the TT genotype was significantly more frequent among Helicobacter pylori-negative patients aged ≤44 years (age ≤ 44 years vs. > 44 years, P = 0.039). Patients with TT genotype showed a higher ratio of incisura with atrophy or intestinal metaplasia (TT vs. CC + CT, P = 0.02). Furthermore, TT genotype was associated with more severe lesions compared with the CC + CT genotypes (TT vs. CC + CT for atrophy: P = 0.07; for intestinal metaplasia: P = 0.01; for moderate-to-severe lesions: P = 0.01). OLGA and OLGIM stages III-IV were observed more frequently in patients with TT genotype compared with CC + CT genotypes (for OLGA: P = 0.003; for OLGIM: P = 0.036). Conclusions: The MTHFR 677C > T TT genotype showed an increased risk of moderate-to-severe lesions by OLGA and OLGIM stages, and these results indicate that MTHFR C677T polymorphism may act as a predictive marker for precancerous gastric lesions, especially in Helicobacter pylori-negative patients aged ≤44 years.

show abstract

Section: Introductionmentioning

confidence: 99%

Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis patients without Helicobacter pylori infection: a case control study

Kong

Dang

et al. 2020

BMC Cancer

View full text Add to dashboard Cite

show abstract

“…AG is a chronic disorder characterized by the loss of the oxyntic glands and is accompanied by fibrosis or fibromuscular proliferation in the lamina propria, or their replacement with pseudo-pyloric or IM [3,4]. Therefore, early supervision of AG could reduce the incidence of gastric cancer [5].…”

Section: Introductionmentioning

confidence: 99%

Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis: a case control study

Kong¹,

Ye²,

Dang³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Previous reports indicate that the methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism plays a role in gastric cancer. However, whether it influences the development and progression of atrophic gastritis remains unclear. We aim to determine the possible association between the MTHFR 677C > T polymorphism and the severity of atrophic gastritis. Methods A total 128 patients with atrophic gastritis were included in the study. The presence and severity of gastric atrophy was assessed by histology using OLGA and OLGIM Gastritis Staging System. MTHFR 677C > T genotyping was performed by digital fluorescence molecular hybridization. Categorical variables were analyzed by percentages using the χ2 test. Results In this study, the TT genotype was significantly more frequent among patients aged ≤ 44 years (age ≤ 44 years vs. >44 years, P = 0.039). Patients with the TT genotype showed a higher ratio of incisura with atrophy or intestinal metaplasia (TT vs. CC + CT, P = 0.02). Furthermore, the TT genotype was associated with more severe lesions compared with the CC + CT genotypes (TT vs. CC + CT for atrophy: odds ratio [OR] = 2.18, P = 0.07; for intestinal metaplasia: OR = 3.39, P = 0.02; for moderate-to-severe lesions: OR = 3.84, P = 0.02). OLGA and OLGIM stages III-IV were observed more frequently in patients with the TT genotype compared with the CC + CT genotypes (for OLGA: OR = 3.98, P = 0.004; for OLGIM: OR = 2.45, P = 0.04). Conclusions The MTHFR 677C > T TT genotype showed an increased risk of moderate-to-severe lesions by OLGA and OLGIM stages, and these results suggest that the MTHFR C677T polymorphism may serve as a predictive marker for precancerous gastric lesions, especially in patients aged ≤ 44 years.

show abstract

Gastritis: The clinico-pathological spectrum

Savarino

Sbaraglia

Bricca

et al. 2021

Digestive and Liver Disease

View full text Add to dashboard Cite

Correction: Grading of Atrophic Gastritis is Useful for Risk Stratification in Endoscopic Screening for Gastric Cancer

Cited by 4 publications

References 0 publications

Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis patients without Helicobacter pylori infection: a case control study

Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis patients without Helicobacter pylori infection: a case control study

Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis: a case control study

Gastritis: The clinico-pathological spectrum

Contact Info

Product

Resources

About