Dual-reflector antennas are widely used in astronomical observations and satellite communication. Structural deformations of the reflectors for radio telescopes are inevitable in operating conditions due to exterior loads, which will cause the surface deviation of the primary reflector and the displacement of the subreflector, then lead to the gain degradation and the misalignment. In this paper, the influence and correction of the misalignment of the dual-reflector antenna have been studied. From the perspective of the wavefront aberration, a method is proposed to correct the wavefront primary aberration by adjusting the subreflector position. The characteristics of wavefront errors caused by the structural deformation of the reflector have been analyzed, and the relationships between the position motions of the subreflector and the Seidel wavefront aberrations are derived. The adjustment quantities of the subreflector are also derived. The results show the suitable adjustment of the position of the subreflector in the lateral and axial directions can effectively correct the effects of the tilt and defocus of the primary aberrations caused by antenna structural deformations.