Correction: Minimal model of interictal and ictal discharges “Epileptor-2”

Chizhov, Anton V.; Zefirov, Artyom V.; Amakhin, Dmitry V.; Smirnova, Elena Y.; Zaitsev, Aleksey V.

doi:10.1371/journal.pcbi.1007359

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“…Initiation and propagation of epileptic discharges in the cortex are partially determined by the local synaptic connectivity of coupled populations of glutamatergic and GABAergic neurons ( Chizhov et al. 2019 ).…”

Section: Resultsmentioning

confidence: 99%

Retrosplenial Cortex Contributes to Network Changes during Seizures in the GAERS Absence Epilepsy Rat Model

Wachsmuth

Datunashvili

Kemper

et al. 2021

Cerebral Cortex Communications

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Resting state-fMRI (rs-fMRI) was performed to explore brain networks in Genetic Absence Epilepsy Rats from Strasbourg (GAERS) and in non-epileptic controls (NEC) during monitoring of the brain state by simultaneous optical Ca2+-recordings. Graph theoretical analysis allowed for identification of acute and chronic network changes and revealed preserved small world topology before and after seizure onset. The most prominent acute change in network organization during seizures was the segregation of cortical regions from the remaining brain. Stronger connections between thalamic with limbic regions compared to pre-seizure state indicated network regularization during seizures. When comparing between strains, intra-thalamic connections were prominent in NEC, on local level represented by higher thalamic strengths and hub scores. Subtle differences were observed for retrosplenial cortex (RS), forming more connections beyond cortex in epileptic rats, and showing a tendency to lateralization during seizures. A potential role of RS as hub between subcortical and cortical regions in epilepsy was supported by increased numbers of parvalbumin-positive (PV+) interneurons together with enhanced inhibitory synaptic activity and neuronal excitability in pyramidal neurons. By combining multimodal fMRI data, graph theoretical methods, and electrophysiological recordings we identified the RS as promising target for modulation of seizure activity and/or comorbidities.

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Section: Resultsmentioning

confidence: 99%