Correction of E.S.R. in Anaemia

Poole, J. C. F.; Summers, G. A. C.

doi:10.1136/bmj.1.4754.353

Cited by 21 publications

(5 citation statements)

References 5 publications

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“…3). In agreement to these results, the relation of ESR to haematocrit has been found to be inversely proportional by the majority of studies [11,[30][31][32][33][34], while the opposite dependence has been also reported [35]. Thereby in the clinical evaluation of ESR the haematocrit is simultaneously considered.…”

Section: Discussionsupporting

confidence: 59%

Red blood cell sedimentation rate measurements in a high aspect ratio microchannel

Passos

Louka

Vryonidis

et al. 2022

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BACKGROUND: The erythrocyte sedimentation rate (ESR) test is commonly used in clinical practice for monitoring, screening and diagnosing pathological conditions and diseases related to the inflammatory response of the immune system. Several ESR techniques have been developed over the years improving the reliability, the precision and the duration of the measurement. OBJECTIVE: In the present study a new low cost micro-ESR technique is described providing the major advantage of reducing the measurement time and the blood sample volume by multiple times compared to the commercial methods. METHODS: Blood samples were obtained from healthy donors within the age group of 24–28 years and the haematocrit was adjusted to 30%, 40% and 50% . The ESR of the samples was measured utilizing a surface tension driven (STD) microfluidic chip and a monitoring device. RESULTS: The evaluation of the method showed a high correlation (0.94, p < 10–5) at all haematocrit levels with the commercial instrument indicating the feasibility of the technique. CONCLUSIONS: This micro-ESR technique provides the potential for a simple, low cost and fast tool for ESR measurement using low blood volume acquired by finger prick.

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Section: Discussionsupporting

confidence: 59%

Red blood cell sedimentation rate measurements in a high aspect ratio microchannel

Passos

Louka

Vryonidis

et al. 2022

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“…However, this did not remain in the multivariate analysis in which we chose the cut off of 20 mm/h to be in line with the international classification [24]. Of note however in a developing country, with a high prevalence of iron deficiency [53] and infectious diseases ESR is frequently higher than 20 mm/h without any inflammation so this cut off is possibly not entirely valid for the subcontinent.…”

Section: Discussionmentioning

confidence: 99%

Factors impacting referral of JIA patients to a tertiary level pediatric rheumatology center in North India: a retrospective cohort study

et al. 2020

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Background: JIA studies demonstrate that there is a "window of opportunity" early in the disease course during which appropriate management improves outcomes. No data is available regarding patients' pathway, before first pediatric rheumatology (PR) evaluation in India, a country where health-care costs are self-paid by patients and where a significant shortage of pediatric rheumatologists (PRsts) is known. This study aimed to describe time from onset of symptoms to first PR visit of JIA patients to a tertiary center in India and factors that impact this. Methods: This retrospective study is from data collected at the PR center, Sir Ganga Ram Hospital (SGRH) in New Delhi. JIA patients fulfilling ILAR 2004 criteria and seen at least twice from 1st October 2013 to 30th September 2018 were included. Data collected were: demographic details, history of disease, referral practitioner, clinical and laboratory features, treatments. Mann-Whitney U-test, Chi square and logistic regression were used as appropriate to study factors that determined time to first PR visit. Results: Five hundred and twenty patients were included: 396 were diagnosed at this PR center (group A), 124 were previously diagnosed as JIA and managed by non PRsts before first PR visit (group B). Median time from symptom onset to first PR visit was 4.1 months and median distance travelled 119.5 km. Despite ongoing treatment, group B patients had more aggressive disease and resided further away as compared to Group A patients. On univariate analysis, factors that predicted PR visit within 3 months were private patients, short distance to travel, family history of inflammatory disease, history of fever, history of acute uveitis or high ESR. On multivariate analysis all these factors were significant except high ESR and acute uveitis. Conclusion: Time to first PR assessment at this center was comparable to that seen in western countries. Cost of care and long distance to the center delayed consultation; acuity of complaints and family history of rheumatologic condition hastened referral. Possible solutions to improve referral to PR centers would be to increase the number of PRsts and to improve medical insurance coverage.

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“…A sharp interface, indicating a gel-like collapse behavior, is observed. more, there is disagreement in how hematocrit φ 0 affects the ESR, where the majority of studies finds that the ESR decreases with φ 0 [36][37][38], while others support the opposite dependence [26].…”

mentioning

confidence: 99%

Erythrocyte sedimentation: Fracture and collapse of a high-volume-fraction soft-colloid gel

Darras,

Dasanna,

John

et al. 2021

Preprint

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The erythrocyte sedimentation rate is one of the oldest medical diagnostic methods whose physical mechanisms remain debatable up to date. Using both light microscopy and mesoscale cell-level simulations, we show that erythrocytes form a soft-colloid gel. Furthermore, the high volume fraction of erythrocytes, their deformability, and weak attraction lead to unusual properties of this gel. A theoretical model for the gravitational collapse is developed, whose predictions are in agreement with detailed macroscopic measurements of the interface velocity.

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Correction of E.S.R. in Anaemia

Cited by 21 publications

References 5 publications

Red blood cell sedimentation rate measurements in a high aspect ratio microchannel

Red blood cell sedimentation rate measurements in a high aspect ratio microchannel

Factors impacting referral of JIA patients to a tertiary level pediatric rheumatology center in North India: a retrospective cohort study

Erythrocyte sedimentation: Fracture and collapse of a high-volume-fraction soft-colloid gel

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