2006
DOI: 10.1159/000093196
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Correction of Endothelial Dysfunction in Diabetic Female Rats by Tetrahydrobiopterin and Chronic Insulin

Abstract: Diabetes-induced vascular dysfunction has mainly been studied in males. However, the mechanisms involved may not correspond to those in females. Here we analyzed the effects of tetrahydrobiopterin (BH4) and chronic insulin on the physiology of mesenteric arterioles of alloxan-diabetic female rats. The parameters studied were the mesenteric arteriolar reactivity (intravital microscopy), nitric oxide synthase (NOS) activity (conversion of L-arginine to L-citrulline), eNOS gene expression (RT-PCR), NO … Show more

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Cited by 30 publications
(30 citation statements)
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“…In diabetic rats, reduced levels of BH 4 have been reported. According to these results, BH 4 supplementation to diabetic rats improves the endotheliumdependent relaxation, suggesting that uncoupled eNOS plays a role in diabetic endothelial dysfunction (39). As previously described, oxidative stress may also impair DDAH activity, resulting in increasing levels of ADMA.…”
Section: Endothelial Dysfunction In Diabetes Mellitussupporting
confidence: 74%
See 1 more Smart Citation
“…In diabetic rats, reduced levels of BH 4 have been reported. According to these results, BH 4 supplementation to diabetic rats improves the endotheliumdependent relaxation, suggesting that uncoupled eNOS plays a role in diabetic endothelial dysfunction (39). As previously described, oxidative stress may also impair DDAH activity, resulting in increasing levels of ADMA.…”
Section: Endothelial Dysfunction In Diabetes Mellitussupporting
confidence: 74%
“…Although the nature of the pathogenic link between elevated circulating levels of glucose and cardiovascular complications is a source of debate, it is clearly recognized that hyperglycemia is responsible for the pathogenesis of vascular complica- tions associated with DM. It has been demonstrated that acute or chronic hyperglycemia can cause several changes in vascular function, including a decrease in endotheliumdependent relaxation (37)(38)(39), an increased contractile response of vascular smooth muscle (38,40,41) and a predisposition to the development of inflammatory, thrombotic and atherosclerotic events (42). The progression of vascular disease in DM is largely related to endothelial dysfunction mechanisms.…”
Section: Endothelial Dysfunction In Diabetes Mellitusmentioning
confidence: 99%
“…As uncoupled NOS is a large source of ROS, BH4 deficiency is an important mechanism in promoting oxidative stress. 46 Furthermore, oxidative stress decreases the bioavailability of BH4, furthering superoxide formation and decreasing NO production. Studies in diabetic rats have shown that BH4 supplementation ameliorated endothelium dysfunction.…”
Section: Animal Studiesmentioning
confidence: 99%
“…For instance, diabetic persons often have poor peripheral circulation, which leads to ischemic injury, impaired wound healing, and impaired vision, all of which involve altered endothelial cell function that relates to endothelial nitric oxide (NO) synthase (eNOS) and the generation of NO (2,21). Several studies have shown that HDL acting through its receptor, SR-BI, can stimulate eNOS to produce NO (4,16,24,36).…”
mentioning
confidence: 99%