Correction of F508del-CFTR Trafficking by the Sponge Alkaloid Latonduine Is Modulated by Interaction with PARP

Carlile, Graeme W.; Keyzers, Robert A.; Teske, Katrina A.; Robert, Renaud; Williams, David E.; Linington, Roger G.; Gray, Christopher A.; Centko, Ryan M.; Yan, Luping; Anjos, Suzana M.; Sampson, Heidi M.; Zhang, Donglei; Liao, Jie; Hanrahan, John W.; Andersen, Raymond J.; Thomas, David Y.

doi:10.1016/j.chembiol.2012.08.014

Cited by 44 publications

(45 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…bisacetylenic alcohol ( 191 ) [184]; conicasterol E ( 192 ) [185]; 6”-debromohamacanthin A ( 193 ) [186]; dieckol ( 194 ) [187]; fructigenine A ( 195 ) [188]; geoditin A ( 196 ) [189]; gorgosterol ( 197 ) [190]; gracilioether B ( 198 ) [191]; gracilioether K ( 199 ) [192]; herdmanine K ( 200 ) [193]; hyrtioreticulin A ( 201 ) [194]; new Kunitz-type protease inhibitor InHVJ ( 202 ) [195]; jaspamide ( 203 ) [196]; latonduine A ( 204 ) [197]; leucettine L41 ( 205 ) [169]; manzamine A ( 206 ) [198]; nahuoic acid A ( 207 ) [199]; namalide ( 208 ) [200]; ningalins C and D ( 209 , 210 ) [201]; octaphlorethol A ( 114 ) [120]; petrosaspongiolide M ( 211 ) [202]; petrosiol A ( 212 ) [203]; phidianidine A ( 213 ) [204]; Poly-APS ( 214 ) [205]; Pseudoceratina sp. dibromotyrosine ( 215 ) [206]; pseudopterosin A ( 216 ) [207]; sargachromanol G ( 217 ) [208]; S. graminifolium polysaccharide ( 218 ) [209]; S. patens phloroglucinol ( 219 ) [210]; S. xiamenensis benzopyran ( 220 ) [211]; theonellasterol ( 221 ) [212]; toluquinol ( 222 ) [213]; and U. lactuca fatty acid ( 223 ) [214].…”

Section: Marine Compounds With Miscellaneous Mechanisms Of Actionmentioning

confidence: 99%

Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2017

View full text Add to dashboard Cite

The peer-reviewed marine pharmacology literature from 2012 to 2013 was systematically reviewed, consistent with the 1998–2011 reviews of this series. Marine pharmacology research from 2012 to 2013, conducted by scientists from 42 countries in addition to the United States, reported findings on the preclinical pharmacology of 257 marine compounds. The preclinical pharmacology of compounds isolated from marine organisms revealed antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral and anthelmitic pharmacological activities for 113 marine natural products. In addition, 75 marine compounds were reported to have antidiabetic and anti-inflammatory activities and affect the immune and nervous system. Finally, 69 marine compounds were shown to display miscellaneous mechanisms of action which could contribute to novel pharmacological classes. Thus, in 2012–2013, the preclinical marine natural product pharmacology pipeline provided novel pharmacology and lead compounds to the clinical marine pharmaceutical pipeline, and contributed significantly to potentially novel therapeutic approaches to several global disease categories.

show abstract

Section: Marine Compounds With Miscellaneous Mechanisms Of Actionmentioning

confidence: 99%

Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2017

View full text Add to dashboard Cite

show abstract

“…This approach has recently shown great promise. Screening efforts have yielded a number of compounds that may offer general therapeutic utility for misfolding diseases (Calamini et al, 2012; Carlile et al, 2012; Mu et al, 2008; Tardiff et al, 2013). Interestingly, the rescue afforded by PRs seems to arise through diverse biochemical mechanisms including the modulation of ER stress pathways (Ozcan et al, 2006; Ryno et al, 2013; Wiseman & Balch, 2005), the tuning of heat shock protein (HSP) expression and activity (Calamini et al, 2012), inhibition of the proteasome (Mu et al, 2008), and inhibition of ubiquitin ligases (Tardiff et al, 2013).…”

Section: Proteostasis and The Cellular Trafficking Of α-Helical Mementioning

confidence: 99%

The safety dance: biophysics of membrane protein folding and misfolding in a cellular context

Schlebach

Sanders

2014

Quart. Rev. Biophys.

View full text Add to dashboard Cite

Most biological processes require the production and degradation of proteins, a task that weighs heavily on the cell. Mutations that compromise the conformational stability of proteins place both specific and general burdens on cellular protein homeostasis (proteostasis) in ways that contribute to numerous diseases. Efforts to elucidate the chain of molecular events responsible for diseases of protein folding address one of the foremost challenges in biomedical science. However, relatively little is known about the processes by which mutations prompt the misfolding of α-helical membrane proteins, which rely on an intricate network of cellular machinery to acquire and maintain their functional structures within cellular membranes. In this review, we summarize the current understanding of the physical principles that guide membrane protein biogenesis and folding in the context of mammalian cells. Additionally, we explore how pathogenic mutations that influence biogenesis may differ from those that disrupt folding and assembly, as well as how this may relate to disease mechanisms and therapeutic intervention. These perspectives indicate an imperative for the use of information from structural, cellular, and biochemical studies of membrane proteins in the design of novel therapeutics and in personalized medicine.

show abstract

“…Using chemical proteomics, several PARPs, i.e., PARPs 1-4, as well as TNKS1 and 2, were identified as latonduine binders. Functional analysis revealed that in particular PARP-3 activity is inhibited by latonduines [235]. In accordance with this, another study revealed that inhibiting PARPs, and in particular PARP1, activities restores F508del-CFTR trafficking in different cell lines and mouse embryonic fibroblasts [236].…”

Section: A Role For Parylation In Protein Folding and The Unfolded Prmentioning

confidence: 69%

Multitasking Roles for Poly(ADP-ribosyl)ation in Aging and Longevity

Mangerich

Bürkle

2015

Cancer Drug Discovery and Development

View full text Add to dashboard Cite

Aging is a multifactorial process that depends on diverse molecular and cellular mechanisms, such as genome instability, epigenetic and transcriptional changes, loss of proteostasis, cell death and senescence, metabolic dysfunction, and inflammation. Enzymes of the family of poly(ADP-ribose) polymerases (PARPs) catalyze the synthesis of the biopolymer poly(ADP-ribose) (PAR), a drastic posttranslational modification that plays significant roles in all of these processes. On the one hand, poly(ADP-ribosyl)ation (PARylation) contributes to genome and proteome homeostasis, as it participates in chromatin remodeling, genome maintenance, cell cycle control, and the regulation of the ubiquitin-proteasome system. On the other hand, PARPs and PARylation interfere with cellular and organismic energy metabolism, and act as mediators of inflammation, senescence and cell death. Therefore, PARylation is discussed both as a longevity assurance factor on the one hand and an aging-promoting factor on the other hand. Here we highlight the mechanisms underlying the various roles of PARylation in longevity and aging with a focus on molecular and cellular mechanisms.

show abstract

Correction of F508del-CFTR Trafficking by the Sponge Alkaloid Latonduine Is Modulated by Interaction with PARP

Cited by 44 publications

References 39 publications

Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

The safety dance: biophysics of membrane protein folding and misfolding in a cellular context

Multitasking Roles for Poly(ADP-ribosyl)ation in Aging and Longevity

Contact Info

Product

Resources

About