Correction of haemorheological disturbances in myocardial infarction by diquertin and ascorbic acid

Mb, Plotnikov; Алиев, О. И.; Maslov, M. Ju; Vasiliev, A. S.; Tjukavkina, N. A.

doi:10.1002/ptr.1082

Cited by 9 publications

(2 citation statements)

References 8 publications

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“…Additionally, the study explored the combined effects of diquertin and ascorbic acid in vivo (in living rats) during cerebral ischemia. This combination appeared to lessen the severity of high blood viscosity syndrome, potentially contributing to improved blood flow and red blood cell function (Plotnikov et al, 2003).…”

Section: Ascorbic Acid and Diquertinmentioning

confidence: 99%

Therapeutic potential of berries in age-related neurological disorders

Norouzkhani,

Afshari,

Sadatmadani

et al. 2024

Front. Pharmacol.

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Aging significantly impacts several age-related neurological problems, such as stroke, brain tumors, oxidative stress, neurodegenerative diseases (Alzheimer’s, Parkinson’s, and dementia), neuroinflammation, and neurotoxicity. Current treatments for these conditions often come with side effects like hallucinations, dyskinesia, nausea, diarrhea, and gastrointestinal distress. Given the widespread availability and cultural acceptance of natural remedies, research is exploring the potential effectiveness of plants in common medicines. The ancient medical system used many botanical drugs and medicinal plants to treat a wide range of diseases, including age-related neurological problems. According to current clinical investigations, berries improve motor and cognitive functions and protect against age-related neurodegenerative diseases. Additionally, berries may influence signaling pathways critical to neurotransmission, cell survival, inflammation regulation, and neuroplasticity. The abundance of phytochemicals in berries is believed to contribute to these potentially neuroprotective effects. This review aimed to explore the potential benefits of berries as a source of natural neuroprotective agents for age-related neurological disorders.

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Section: Ascorbic Acid and Diquertinmentioning

confidence: 99%

Therapeutic potential of berries in age-related neurological disorders

Norouzkhani,

Afshari,

Sadatmadani

et al. 2024

Front. Pharmacol.

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“…Diquertin ® is the first pharmaceutical product based on DHQ that has been registered in Russia. It was approved as an antioxidant in the treatment of acute pneumonia, chronic obstructive pulmonary disease, asthma, coronary heart disease, and supraventricular arrhythmia ( Kolhir et al, 1998 ; Plotnikov et al, 2003 ). The reference sample of DHQ was developed to standardize the active pharmaceutical ingredient (API) of Diquertin ® .…”

Section: Introductionmentioning

confidence: 99%

Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects

Terekhov,

Savina,

Pankov

et al. 2024

Front. Chem.

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Dihydroquercetin (DHQ) is a representative of flavonoids that is available on the market as a food supplement and registered as an active pharmaceutical ingredient. The structure of this compound is characterized by the presence of two chiral centers in positions 2 and 3 of the pyranone ring. Current regulatory documentation on DHQ lacks quantitative analysis of the stereoisomers of this flavanonol. This poses potential risks for consumers of DHQ-based dietary supplements and developers of new drugs. This review was conducted to systematize data on the pharmacology of DHQ stereoisomers and the possible methods of controlling them in promising chiral drugs. We found that relying on literature data of polarimetry for the identification of DHQ stereoisomers is currently impossible due to these heterogeneities. NMR spectroscopy allows to distinguishing between trans- and cis-DHQ using chemical shifts values. Only HPLC is currently characterized by sufficient enantioselectivity. Regarding pharmacology, the most active stereoisomer of DHQ should be identified, if the substituents in chiral centers both take part in binding with the biological target. The significant impact of stereochemical structure on the pharmacokinetics of DHQ isomers was reported. The question about these toxicity of these compounds remains open. The results of the conducted review of scientific literature indicate the necessity of revising the pharmacology of DHQ taking into account its stereoisomerism.

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Functional properties of dietary quercetin in cardiovascular health and disease

Xu,

Qu,

et al. 2024

Food Frontiers

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The increasing incidence of cardiovascular diseases has resulted in an escalating need for natural dietary supplements with cardioprotective properties. This review provides a thorough analysis of laboratory and clinical studies conducted on dietary quercetin, a widely available flavonoid, and its influence on the management of cardiovascular health and disease. The references cited in this review were obtained from reputable databases, including SciFinder, Web of Science, and ClinicalTrials.gov, with a specific focus on the period spanning from 1999 to 2023 pertaining to this subject matter. Notably, a bibliometric approach was used to analyze the bibliometric attribute trends of the research on quercetin associated with vascular health for the first time. Numerous investigations conducted on animal and human subjects at different phases of cardiac illness have consistently shown that the administration of quercetin substances improves cardiac function, suggesting the potential efficacy of quercetin in the management of heart disease. Evidently, the consumption of quercetin through dietary sources holds promise in conferring significant cardiovascular benefits through physiological mechanisms and biochemical signaling pathways, thus positioning it as a promising dietary contender for the prevention of cardiovascular disorders. Renewable food resources, including lovage leaves, elderberry, and radish leaves, which are abundant in quercetin, exhibit significant potential for the development and production of novel healthcare products with the objective of preventing cardiovascular disorders. This review is anticipated to provide valuable insights for the advancement of cardioprotective functional foods in the foreseeable future.

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Correction of haemorheological disturbances in myocardial infarction by diquertin and ascorbic acid

Cited by 9 publications

References 8 publications

Therapeutic potential of berries in age-related neurological disorders

Therapeutic potential of berries in age-related neurological disorders

Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects

Functional properties of dietary quercetin in cardiovascular health and disease

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