2023
DOI: 10.1038/s41598-023-30794-7
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Correction of haemorrhagic shock-associated coagulopathy and impaired haemostasis by plasma, prothrombin complex concentrates or an activated protein C-targeted DNA aptamer in mice

Abstract: Even with extensive transfusion support, trauma-induced bleeding often leads to death. Early intervention may improve outcomes, yet which blood products, factor concentrates, or other drugs constitute optimal treatment is unclear. Patients with acute traumatic coagulopathy (ATC), arising from trauma and haemorrhagic shock, have the worst prognosis. Here, multiple interventions were compared in a mouse model of ATC. After the trauma of tissue excision, anaesthetized mice were bled to 35 mm Hg mean arterial pres… Show more

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(2 citation statements)
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“…69 Previous clinical studies led to the treatment of sepsis with activated protein C. Although the potential clinical harm of this therapy was subsequently demonstrated to outweigh any potential benefits, 70 recent experimental data suggest that therapeutic manipulation of the protein C could have a future role in mitigation of TIC. 71…”
Section: Role Of Endothelium In Thromboinflammationmentioning
confidence: 99%
See 1 more Smart Citation
“…69 Previous clinical studies led to the treatment of sepsis with activated protein C. Although the potential clinical harm of this therapy was subsequently demonstrated to outweigh any potential benefits, 70 recent experimental data suggest that therapeutic manipulation of the protein C could have a future role in mitigation of TIC. 71…”
Section: Role Of Endothelium In Thromboinflammationmentioning
confidence: 99%
“…Recent studies also suggest that cell free histones, which are markedly elevated after injury and the ensuing inflammatory response, lead to inhibition of protein C activation 69 . Previous clinical studies led to the treatment of sepsis with activated protein C. Although the potential clinical harm of this therapy was subsequently demonstrated to outweigh any potential benefits, 70 recent experimental data suggest that therapeutic manipulation of the protein C could have a future role in mitigation of TIC 71 …”
Section: Role Of Endothelium In Thromboinflammationmentioning
confidence: 99%