“…Studies in the literatures (Velthuizen et al, 1998;Sled et al, 1998;Mangin, 2000) have theoretically proved that the model of a smooth multiplicative bias field and additive noise is reasonable. From a hardware perspective, the author in (Collewet et al, 2002) proposed a physics based model, which is different from the simple multiplicative model of bias field. This model is useful in in spin-echo T(1) images, but need some special parameters and references, and the results is still unreliable.…”