Correction of intermittent hypoxia reduces inflammation in obese subjects with obstructive sleep apnea

Perrini, Sebastio; Cignarelli, Angelo; Quaranta, Vitaliano Nicola; Falcone, Vito Antonio; Kounaki, Stella; Porro, Stefania; Ciavarella, Alessandro; Ficarella, Romina; Barbaro, Maria Pia Foschino; Genchi, Valentina Annamaria; Nigro, Pasquale; Carratù, Pierluigi; Natalicchio, Annalisa; Laviola, Luigi; Resta, Onofrio; Giorgino, Francesco

doi:10.1172/jci.insight.94379

Cited by 58 publications

(59 citation statements)

References 57 publications

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“…Indeed, the excess of adipose tissue narrows breath airways but also is involved in the releases of cytokines [37]. In particular IL-1, IL-6 and TNF-α are not only proin ammatory cytokines but also a 'sleep-regulatory substances' [21,38]. TNF-α and IL-1b, whose secretion follows a circadian rhythm, with the highest TNF-α and IL-6 secretion during the night (between 01:00 and 02:00 hours), are involved in the physiological regulation of sleep in both animals and humans [39], playing an important role in the slow-wave sleep [40].…”

Section: Discussionmentioning

confidence: 99%

“…In both genders waist circumference has been reported to have a tight association with sleep disturbance [18]. This is because visceral adipose tissue is the main source of pro-in ammatory cytokines, such as interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF)-α that, beyond chronic low-grade in ammation [19,20], could have a role in sleep regulation such that they are called 'sleep-regulatory substances' [21,22]. Quarantine was also associated to a change of working modalities in most of the people.…”

Section: Introductionmentioning

confidence: 99%

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Does Sars-Cov-2 Threaten Our Dreams? Effect of Quarantine on Sleep Quality and Body Mass Index

Barrea

Pugliese

Framondi

et al. 2020

Preprint

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Background: COVID 19- related quarantine led to a sudden and radical lifestyle changes, in particular in eating habits. Objectives of the study were to investigate the effect of quarantine on sleep quality (SQ) and body mass index (BMI), and if change in SQ was related to working modalities.Materials: We enrolled 121 adults (age 44.9±13.3 years and 35.5% males). Anthropometric parameters, working modalities and physical activity were studied. Sleep quality was evaluated by the Pittsburgh Sleep Quality Index (PSQI). At baseline, the enrolled subjects were assessed in outpatient clinic and after 40 days of quarantine/lockdown by phone interview. Results: Overall, 49.6% of the subjects were good sleepers (PSQI < 5) at the baseline and significantly decreased after quarantine (p<0.001). In detail, sleep onset latency (p<0.001), sleep efficiency (p=0.03), sleep disturbances (p<0.001), and daytime dysfunction (p<0.001) significantly worsened. There was also a significant increase in BMI values in normal weight (p=0.023), in subjects grade I (p=0.027) and II obesity (p=0.020). In all cohort, physical activity was significantly increased (p=0.004). However, analyzing the data according gender difference, males significantly increased physical activity compared to females in which there was only a trend without reaching statistical significance (46.5% vs 74.4%; p=0.015 and 50.0% vs 64.1%, p=0.106; in males and females, respectively). Also, smart working activity resulted in a significant worsening of SQ, particularly in males (p<0.001). Conclusions: Quarantine was associated to a worsening of SQ, particularly in males doing smart working, and to an increase in BMI values.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Does Sars-Cov-2 Threaten Our Dreams? Effect of Quarantine on Sleep Quality and Body Mass Index

Barrea

Pugliese

Framondi

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Indeed, the excess of adipose tissue narrows breath airways but it is also involved in the releases of cytokines [37]. In particular IL-1, IL-6 and TNF-α are not only pro-in ammatory cytokines but also a 'sleep-regulatory substances' [21,38]. TNF-α and IL-1b, whose secretion follows a circadian rhythm, with the highest TNF-α and IL-6 secretion during the night (between 01:00 and 02:00 hours), are involved in the physiological regulation of sleep in both animals and humans [39], playing an important role in the slow-wave sleep [40].…”

Section: Sleep Qualitymentioning

confidence: 99%

“…In both genders waist circumference has been reported to have a tight association with sleep disturbance [18]. This is because visceral adipose tissue is the main source of pro-in ammatory cytokines, such as interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF)-α that, beyond chronic low-grade in ammation [19,20], could have a role in sleep regulation such that they are called 'sleep-regulatory substances' [21,22]. Quarantine was also associated with a change of working modalities in most of the people.…”

Section: Introductionmentioning

confidence: 99%

Does Sars-Cov-2 threaten our dreams? Effect of Quarantine on Sleep Quality and Body Mass Index

Barrea

Pugliese

Framondi

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: COVID 19- related quarantine led to a sudden and radical lifestyle changes, in particular in eating habits. Objectives of the study were to investigate the effect of quarantine on sleep quality (SQ) and body mass index (BMI), and if change in SQ was related to working modalities.Materials: We enrolled 121 adults (age 44.9±13.3 years and 35.5% males). Anthropometric parameters, working modalities and physical activity were studied. Sleep quality was evaluated by the Pittsburgh Sleep Quality Index (PSQI) questionnaire. At baseline, the enrolled subjects were assessed in outpatient clinic and after 40 days of quarantine/lockdown by phone interview. Results: Overall, 49.6% of the subjects were good sleepers (PSQI < 5) at the baseline and significantly decreased after quarantine (p<0.001). In detail, sleep onset latency (p<0.001), sleep efficiency (p=0.03), sleep disturbances (p<0.001), and daytime dysfunction (p<0.001) significantly worsened. There was also a significant increase in BMI values in normal weight (p=0.023), in subjects grade I (p=0.027) and II obesity (p=0.020). In all cohort, physical activity was significantly decreased (p=0.004). However, analyzing the data according gender difference, males significantly decreased physical activity as well as females in which there was only a trend without reaching statistical significance (53.5% vs 25.6%; p=0.015 and 50.0% vs 35.9%, p=0.106; in males and females, respectively). In addition, smart working activity resulted in a significant worsening of SQ, particularly in males (p<0.001). Conclusions: Quarantine was associated to a worsening of SQ, particularly in males doing smart working, and to an increase in BMI values.

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“…Patients with OSA are at greater risk for metabolic dysfunction including insulin resistance, type 2 diabetes mellitus, dyslipidemia, and display evidence of adipose tissue inflammation and dysfunction [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Of note, both IH and SF have been independently associated with metabolic dysfunction, and acute exposures to IH were shown to decrease insulin sensitivity in healthy human volunteers [ 16 , 17 ]. In addition, studies in both rodents and humans have consistently reported that exposures to IH affects whole-body metabolic homeostasis, but the underlying mechanism(s) and the metabolic organs involved remain unclear [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ].…”

Section: Sleep-disordered Breathingmentioning

confidence: 99%

Exosome and Macrophage Crosstalk in Sleep-Disordered Breathing-Induced Metabolic Dysfunction

Kheirandish‐Gozal

Gozal

2018

IJMS

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Obstructive sleep apnea (OSA) is a highly prevalent worldwide public health problem that is characterized by repetitive upper airway collapse leading to intermittent hypoxia, pronounced negative intrathoracic pressures, and recurrent arousals resulting in sleep fragmentation. Obesity is a major risk factor of OSA and both of these two closely intertwined conditions result in increased sympathetic activity, oxidative stress, and chronic low-grade inflammation, which ultimately contribute, among other morbidities, to metabolic dysfunction, as reflected by visceral white adipose tissue (VWAT) insulin resistance (IR). Circulating extracellular vesicles (EVs), including exosomes, are released by most cell types and their cargos vary greatly and reflect underlying changes in cellular homeostasis. Thus, exosomes can provide insights into how cells and systems cope with physiological perturbations by virtue of the identity and abundance of miRNAs, mRNAs, proteins, and lipids that are packaged in the EVs cargo, and are secreted from the cells into bodily fluids under normal as well as diseased states. Accordingly, exosomes represent a novel pathway via which a cohort of biomolecules can travel long distances and result in the modulation of gene expression in selected and targeted recipient cells. For example, exosomes secreted from macrophages play a critical role in innate immunity and also initiate the adaptive immune response within specific metabolic tissues such as VWAT. Under normal conditions, phagocyte-derived exosomes represent a large portion of circulating EVs in blood, and carry a protective signature against IR that is altered when secreting cells are exposed to altered physiological conditions such as those elicited by OSA, leading to emergence of IR within VWAT compartment. Consequently, increased understanding of exosome biogenesis and biology should lead to development of new diagnostic biomarker assays and personalized therapeutic approaches. Here, the evidence on the major biological functions of macrophages and exosomes as pathophysiological effectors of OSA-induced metabolic dysfunction is discussed.

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Correction of intermittent hypoxia reduces inflammation in obese subjects with obstructive sleep apnea

Abstract: In obese subjects with obstructive sleep apnea (OSA), chronic intermittent hypoxia (CIH) may be linked to systemic and adipose tissue inflammation

Cited by 58 publications

References 57 publications

Does Sars-Cov-2 Threaten Our Dreams? Effect of Quarantine on Sleep Quality and Body Mass Index

Does Sars-Cov-2 Threaten Our Dreams? Effect of Quarantine on Sleep Quality and Body Mass Index

Does Sars-Cov-2 threaten our dreams? Effect of Quarantine on Sleep Quality and Body Mass Index

Exosome and Macrophage Crosstalk in Sleep-Disordered Breathing-Induced Metabolic Dysfunction

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