Purpose: To develop a method for shot-by-shot distortion correction of single-shot echo-planar imaging (EPI) that is capable of correcting each image individually using a distortion measurement performed during acquisition of the image itself.
Materials and Methods:The recently-introduced method known as two reduced acquisitions interleaved (TRAIL) was extended to measure the distribution of the main magnetic field B 0 with each shot. This corresponded to a map of distortion, and allowed distortion to be corrected in the acquired images.
Results:Distortion-corrected images were demonstrated in the human brain. The distortion field could be directly visualized using the "stripe" distribution imposed by the TRAIL pulse sequence. This confirmed the success of the correction. Over a time-course measurement of 10 images, variance was reduced by using shot-by-shot distortion correction compared to correction with a constant field map.
Conclusion:Shot-by-shot distortion correction may be performed for EPI images acquired using an extension of the TRAIL technique, ensuring that the correction reflects the actual distortion pattern and not merely a previously measured, but possibly no longer valid, distortion field. This avoids errors due to changes in the distortion field or misregistration of a previously measured distortion map resulting from subject motion. ECHO-PLANAR IMAGING (EPI) (1,2) can acquire images very rapidly with a high signal-to-noise ratio (SNR) per unit time. For many applications of EPI, very high main magnetic fields (B 0 ) allow increases in SNR, blood oxygen level-dependent (BOLD) responses, or T1 to be exploited. However, higher magnetic fields also bring greater problems-in particular an increased sensitivity to magnetic susceptibility differences between tissues or between tissue and air, which cause strong variations in B 0 and can thus degrade image quality. The T2* relaxation times are reduced, resulting in rapid signal decay during the EPI readout. Also the susceptibility-related inhomogeneities in B 0 correspond to local variations in the Larmour frequency ( 0 ), which leads to image distortions along the phase-encode direction. For time-course studies, another problem is that the B 0 distribution depends on the subject orientation, therefore, the distortion can change if the subject moves (3-5). These problems have prevented many further applications of single-shot EPI. Effective methods to correct distortion are therefore needed.There are several algorithms that can measure and correct EPI distortion resulting from susceptibility effects (4 -10). One simple algorithm compares two separate images acquired traversing k-space in opposite directions along the phase-encode (PE) direction (6). Other approaches use a field map measurement, since the displacement field at any given point is proportional to the susceptibility-induced change in B 0 (7). A B 0 field map can be calculated from the phase change between two or more separately acquired gradient-echo or EPI images with different echo tim...