Correction of the high blood viscosity syndrome by a mixture of diquertin and ascorbic acid <i>in vitro </i>and <i>in vivo</i>

Mb, Plotnikov; Алиев, О. И.; Maslov, M. Ju; Vasiliev, A. S.; Tjukavkina, N. A.

doi:10.1002/ptr.1113

Cited by 14 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The blood was collected from the common carotid artery under ether narcosis and stabilized with 3.8% sodium citrate (1:9 citrate/ blood ratio). The drug effects on blood viscosity were evaluated using the in vitro blood hyperviscosity model, reproduced by blood incubation at 44 o C. The type and intensity of shifts in individual hemorheological values in this model are comparable to changes developing in some pathological states, which suggests the use of this model for evaluation of hemorheological characteristics of drugs [13].Blood viscosity was measured on an AKP-2 rotation viscosimeter at shear rates of 5-300 sec -1 before and after 60-min incubation of the samples. Platelet-rich and platelet-poor plasma (PRP and PPP, respectively) were prepared and platelet count was evaluated [1].…”

mentioning

confidence: 99%

Effect of n-tyrosol on blood viscosity and platelet aggregation

Mb¹,

Чернышева²,

Smol’yakova³

et al. 2007

Bull Exp Biol Med

Self Cite

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Effect of n-tyrosol on blood viscosity and platelet aggregation

Mb¹,

Чернышева²,

Smol’yakova³

et al. 2007

Bull Exp Biol Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…The effect of vitamin C on viscosity in this in vitro study was consistent with the findings in human studies where blood viscosity was significantly inversely associated with acute ingestion and blood concentration of vitamin C 16 17 18 . Vitamin C was also shown to potentiate the effects of a therapeutic agent on rheological indicators including decreasing blood viscosity and erythrocyte aggregation, and increasing deformability of erythrocytes 19 . Our in vitro results represent the situation in vivo , and suggest that co-administration of vitamin C with artemether/lumefantrine may increase the risk of haemolysis and possible anaemia in patients with malaria.…”

Section: Resultsmentioning

confidence: 99%

In vitro effects of co-incubation of blood with artemether/lumefantrine & vitamin C on the viscosity & elasticity of blood

McKoy

Kong-Quee

Pepple

2016

Indian Journal of Medical Research

View full text Add to dashboard Cite

Background & objectives:The antimalarial combination drug artemether/lumefantrine has been shown to be effective against malaria parasite through its haemolytic action. This drug is sometimes co-administered with vitamin C in patients with malaria. Vitamin C is associated with antioxidant properties which would be expected to protect against haemolytic effects of this antimalarial drug. This study was designed to investigate in vitro effects of co-incubation of artemether/lumefantrine with vitamin C on the viscosity and elasticity of blood.Methods:Blood was collected from 12 healthy female volunteers with normal haemoglobin genotype (HbAA). A Bioprofiler was used to measure the viscosity and elasticity of untreated blood samples (control) and samples exposed to artemether/lumefantrine (0.06/0.36 mg/ml) alone and with low or high dose vitamin C (equivalent to adult doses of 100 or 500 mg).Results:Artemether/lumefantrine significantly (P<0.05) reduced viscosity of blood from 4.72 ± 0.38 to 3.78 ± 0.17 mPa.s. Addition of vitamin C (500 mg) further reduced blood viscosity to 2.67 ± 0.05 mPa.s. The elasticity of blood was significantly (P<0.05) reduced from 0.33 ± 0.04 mPa.s to 0.24 ± 0.03 mPa.s by the antimalarial drug, and further reduced to 0.13 ± 0.02 mPa.s in the presence of vitamin C (500 mg).Interpretation & conclusions:Co-incubation of blood with vitamin C and antimalarial combination drug potentiates the haemolytic effects of the latter on reducing blood viscosity and elasticity in vitro. This may possibly have implications in relation to haemolysis in patients receiving vitamin C supplementation with artemether/lumefantrine during malaria therapy.

show abstract

“…Additionally, the study explored the combined effects of diquertin and ascorbic acid in vivo (in living rats) during cerebral ischemia. This combination appeared to lessen the severity of high blood viscosity syndrome, potentially contributing to improved blood flow and red blood cell function ( Plotnikov et al, 2003 ).…”

Section: High Blood Viscosity Syndromementioning

confidence: 99%

Therapeutic potential of berries in age-related neurological disorders

Norouzkhani,

Afshari,

Sadatmadani

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Aging significantly impacts several age-related neurological problems, such as stroke, brain tumors, oxidative stress, neurodegenerative diseases (Alzheimer’s, Parkinson’s, and dementia), neuroinflammation, and neurotoxicity. Current treatments for these conditions often come with side effects like hallucinations, dyskinesia, nausea, diarrhea, and gastrointestinal distress. Given the widespread availability and cultural acceptance of natural remedies, research is exploring the potential effectiveness of plants in common medicines. The ancient medical system used many botanical drugs and medicinal plants to treat a wide range of diseases, including age-related neurological problems. According to current clinical investigations, berries improve motor and cognitive functions and protect against age-related neurodegenerative diseases. Additionally, berries may influence signaling pathways critical to neurotransmission, cell survival, inflammation regulation, and neuroplasticity. The abundance of phytochemicals in berries is believed to contribute to these potentially neuroprotective effects. This review aimed to explore the potential benefits of berries as a source of natural neuroprotective agents for age-related neurological disorders.

show abstract

Correction of the high blood viscosity syndrome by a mixture of diquertin and ascorbic acid in vitro and in vivo

Cited by 14 publications

References 11 publications

Effect of n-tyrosol on blood viscosity and platelet aggregation

Effect of n-tyrosol on blood viscosity and platelet aggregation

In vitro effects of co-incubation of blood with artemether/lumefantrine & vitamin C on the viscosity & elasticity of blood

Therapeutic potential of berries in age-related neurological disorders

Contact Info

Product

Resources

About