Correction of vitamin D deficiency in critically ill patients - VITdAL@ICU study protocol of a double-blind, placebo-controlled randomized clinical trial

Amrein, Karin; Schnedl, Christian; Berghold, Andrea; Pieber, Thomas R.; Dobnig, Harald

doi:10.1186/1472-6823-12-27

Cited by 28 publications

(17 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 Scandinavian diets contain more vitamin D due to higher fatty fish intake and dairy products supplementation with vitamin D. 11 The baseline prevalence of VDI amongst ICU patients is 30-40%. 12 In this study, we found that 84.6% of COVID-19 ICU patients had VDI, vs. 57.1% of floor patients. Strikingly, 100% of ICU patients less than 75 years old had VDI.…”

Section: Discussionmentioning

confidence: 53%

Vitamin D insufficiency is prevalent in severe COVID-19

Lau

Majumder

Torabi

et al. 2020

Preprint

149

142

View full text Add to dashboard Cite

Background: COVID-19 is a major pandemic that has killed more than 196,000 people. The COVID-19 disease course is strikingly divergent. Approximately 80-85% of patients experience mild or no symptoms, while the remainder develop severe disease. The mechanisms underlying these divergent outcomes are unclear. Emerging health disparities data regarding African American and homeless populations suggest that vitamin D insufficiency (VDI) may be an underlying driver of COVID-19 severity. To better define the VDI-COVID-19 link, we determined the prevalence of VDI among our COVID-19 intensive care unit (ICU) patients. Methods: In an Institutional Review Board approved study performed at a single, tertiary care academic medical center, the medical records of COVID-19 patients were retrospectively reviewed. Subjects were included for whom serum 25-hydroxycholecalcifoerol (25OHD) levels were determined. COVID-19-relevant data were compiled and analyzed. We determined the frequency of VDI among COVID-19 patients to evaluate the likelihood of a VDI-COVID-19 relationship. Results: Twenty COVID-19 patients with serum 25OHD levels were identified; 65.0% required ICU admission.The VDI prevalence in ICU patients was 84.6%, vs. 57.1% in floor patients. Strikingly, 100% of ICU patients less than 75 years old had VDI. Coagulopathy was present in 62.5% of ICU COVID-19 patients, and 92.3% were lymphocytopenic. Conclusions: VDI is highly prevalent in severe COVID-19 patients. VDI and severe COVID-19 share numerous associations including hypertension, obesity, male sex, advanced age, concentration in northern climates, coagulopathy, and immune dysfunction. Thus, we suggest that prospective, randomized controlled studies of VDI in COVID-19 patients are warranted.

show abstract

Section: Discussionmentioning

confidence: 53%

Vitamin D insufficiency is prevalent in severe COVID-19

Lau

Majumder

Torabi

et al. 2020

Preprint

149

142

View full text Add to dashboard Cite

show abstract

“…The primary outcome in this study was hospital LOS with multiple secondary outcomes. 37 The authors of the VITdAL@ICU study found that there was no statistically significant difference in hospital LOS or ICU LOS between intervention group and placebo group. There was no significant difference between the 2 groups for incidence of mortality, causes of death, severity of disease, or mechanical ventilation.…”

Section: Clinical Trialsmentioning

confidence: 96%

“…6,7,18,19,22,24,[36][37][38][39][40] The timing of when 25(OH)D level was checked relative to critical care initiation seemed to have an influence on the prevalence of deficiency. When vitamin D level was assessed within 7-365 days before ICU admission, the incidence of deficiency tended to be lower 6,18-20 compared with checking 25(OH)D levels closer to the time of ICU admission.…”

Section: Prevalence Of Deficiency In Critical Illnessmentioning

confidence: 99%

Outcomes of Vitamin D Supplementation in Adults Who are Deficient and Critically Ill: A Review of the Literature

Williams

Heuberger

2016

American Journal of Therapeutics

View full text Add to dashboard Cite

Vitamin D deficiency is known to be common in the general population and has been linked to all-cause mortality. The classically recognized role of vitamin D is its involvement in calcium and phosphorous homeostasis and bone health. Recent evidence suggests that vitamin D may also play a role in other nonskeletal processes, such as anti-proliferation, immunity, regulation of hormone section, and muscle strength. An extensive literature review of vitamin D and critical illness from 2000 to 2015 (PubMed and CINAL) produced multiple observational studies revealing a high prevalence of vitamin D deficiency in intensive care patients. Many of these studies have indicated that there is an association between vitamin D deficiency and clinical outcomes such as mortality, sepsis, duration of mechanical ventilation, and length of stay. This review article provides an overview of vitamin D physiology in adults, a summary of observational studies on vitamin D deficiency in critical illness, and an examination of the few clinical trials on vitamin D supplementation in intensive care patients.

show abstract

“…The VITdAL@ICU trial is an investigator-initiated, noncommercial, prospective, randomized, controlled trial comparing high-dose oral cholecalciferol (vitamin D,) versus placebo treatment in a mixed population of 480 critically ill patients with low 25OHD levels (< 20 ng/mL) at the time of admission to the ICU study enrollment. Patients will receive an initial bolus dose of 540,000 IU of vitamin D, and 90,000 IU of vitamin D^ on a monthly basis for 5 months resulting in a total treatment observation period of 6 months (25). My hope is that this study will shed much needed light on the role of vitamin D in improving outcome in our critically ill patients.…”

mentioning

confidence: 98%

Vitamin D—Do Our Patients Need Not Just a Room With a View, but One With Sunshine?*

Murray¹

2014

Critical Care Medicine

View full text Add to dashboard Cite

Correction of vitamin D deficiency in critically ill patients - VITdAL@ICU study protocol of a double-blind, placebo-controlled randomized clinical trial

Cited by 28 publications

References 63 publications

Vitamin D insufficiency is prevalent in severe COVID-19

Vitamin D insufficiency is prevalent in severe COVID-19

Outcomes of Vitamin D Supplementation in Adults Who are Deficient and Critically Ill: A Review of the Literature

Vitamin D—Do Our Patients Need Not Just a Room With a View, but One With Sunshine?*

Contact Info

Product

Resources

About