Correction: Oligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space

Letter to the Editor: Alcohol-induced extracellular ASC specks perpetuate liver inflammation and damage in alcohol-associated hepatitis even after alcohol cessation

“…ASC specks with a low degree of oligomerization are more prone to interaction with pro-caspase-1 and promote its activation. [2] Moreover, the ASC oligomers can change their structure independently of NLRP3 to promote the recruitment of pro-caspase-1. [3] Thus, to fully explain the different biological effects between macrophage-and hepatocyte-derived ASC specks, it is necessary to determine the oligomerization degree of ex-ASC specks in depth, which will have a notable impact on the final result.Third, in this research, MCC950 inhibition is not sufficient to prove that NLRP3 level in liver-derived ex-ASC specks is critical in amplifying systemic and liver inflammation in vivo.…”