Correction: p63α modulates c-Myc activity via direct interaction and regulation of MM1 protein stability

Abstract

Present:In the title and abstract, the 'β' symbol was mistakenly inserted instead of 'α'. The title should read p63α modulates c-Myc activity via direct interaction and regulation of MM1 protein stability All symbols of "β" in the ABSTRACT should be changed into "α". p63β modulates c-Myc activity via direct interaction and ABSTRACTBoth p53-related p63 and c-Myc are transcription factors playing key roles in cell proliferation, survival, development and tumorigenesis. In the present study, we identified that MM1, a c-Myc inhibitor, specifically binds to C-termini of p63α (including ΔNp63α and TAp63α). Further study demonstrates that p63α facilitates MM1 protein degradation via proteasomal pathway, resulting in elevation of c-Myc transactivation activity. Knockdown of ΔNp63α leads to decrease in c-Myc protein levels, concomitant with reduced expression of CDK4 and Cyclin D1, and impaired cell cycle progression, both of which are effectively reversed by simultaneous knockdown of MM1. Moreover, expression of p63 and CDK4 is concomitantly upregulated in B-cell acute lymphoblastic leukemia. Together, this study reveals a novel crosstalk between p63 and c-Myc that may play an important role in cell cycle progression and tumorigenesis.

Decreased c-Myc mRNA Stability via the MicroRNA 141-3p/AUF1 Axis Is Crucial for p63α Inhibition of Cyclin D1 Gene Transcription and Bladder Cancer Cell Tumorigenicity

“…In contrast to previous studies showing that c-Myc could be posttranslationally regulated (55), as well as our published study showing that c-Myc protein degradation is regulated by FBW7 in arsenite-treated cells (56), Han and colleagues report that c-Myc activity is modulated by p63␣ via direct protein-protein interaction in B-cell acute lymphoblastic leukemia (57). In our current study, we have demonstrated that p63␣ overexpression promotes c-Myc mRNA degradation, thereby inhibiting c-Myc protein expression in BC cells.…”