Correction: Poly(<i>N</i>-isopropyl acrylamide)–poly(ethylene glycol)–poly(<i>N</i>-isopropyl acrylamide) as a thermoreversible gelator for topical administration

Haddow, Peter; McAuley, William J.; Kirton, Stuart; Cook, Michael T.

doi:10.1039/d0ma90026e

Cited by 3 publications

(8 citation statements)

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“…4C, Table 1, and table S1). Like in all thermosensitive polymers ( 54 , 55 ), onset of gelation shifts to lower temperatures with increasing solution concentration (Fig. 4C).…”

Section: Resultsmentioning

confidence: 68%

Injectable bottlebrush hydrogels with tissue-mimetic mechanical properties

et al. 2022

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Injectable hydrogels are desired in many biomedical applications due to their minimally invasive deployment to the body and their ability to introduce drugs. However, current injectables suffer from mechanical mismatch with tissue, fragility, water expulsion, and high viscosity. To address these issues, we design brush-like macromolecules that concurrently provide softness, firmness, strength, fluidity, and swellability. The synthesized linear-bottlebrush-linear (LBL) copolymers facilitate improved injectability as the compact conformation of bottlebrush blocks results in low solution viscosity, while the thermoresponsive linear blocks permit prompt gelation at 37°C. The resulting hydrogels mimic the deformation response of supersoft tissues such as adipose and brain while withstanding deformations of 700% and precluding water expulsion upon gelation. Given their low cytotoxicity and mild inflammation in vivo, the developed materials will have vital implications for reconstructive surgery, tissue engineering, and drug delivery applications.

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“…4C, Table 1, and table S1). Like in all thermosensitive polymers ( 54 , 55 ), onset of gelation shifts to lower temperatures with increasing solution concentration (Fig. 4C).…”

Section: Resultsmentioning

confidence: 68%

Injectable bottlebrush hydrogels with tissue-mimetic mechanical properties

et al. 2022

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“…Thermogelling PNIPAM‐PEG‐PNIPAM, in which T gel is less concentration dependent compared to Poloxamer copolymers, forms more stable hydrogels at body temperature. [ 44 ] These block copolymers exhibit also different solubilizing abilities of hydrophobic drugs. Progesterone, a hydrophobic hormone, showed better solubility in NIPAM copolymer (≈1.5 fold) than in the Poloxamer hydrogel.…”

Section: Recent Advances In the Design Of Hydrophobized Hydrogels As ...mentioning

confidence: 99%

“…After 72 h, ≈75% of entrapped progesterone was delivered from 20% w/v Poloxamer 407, whereas 25% of the drug was released from NIPAM‐based hydrogel. [ 44 ] The increased drug solubilization along with the decreased rate of its release observed for NIPAM copolymer was ascribed to a higher degree of polymerization of microphase separated NIPAM domains (DP = 196), whereas DP of poly(propylene oxide) was equal to 65 in Poloxamer. The amphiphilic structure of both copolymers also facilitated the capture of a hydrophilic drug (tenofovir disoproxil fumarate), which was located in the external areas of their micelles.…”

Section: Recent Advances In the Design Of Hydrophobized Hydrogels As ...mentioning

confidence: 99%

“…PNIPAM 98 ‐PEG 122 ‐PNIPAM 98 aqueous solutions at a concentration between 20% and 50% (w/v) display the gelation temperature above 30 °C, however below 40 °C. [ 44 ] Moreover, the hydrogels based on PNIPAM 98 ‐PEG 122 ‐PNIPAM 98 displayed a higher resistance to dissolution in comparison to Poloxamer systems.…”

Section: The Construction Strategies Of Hydrophobized Hydrogelsmentioning

confidence: 99%

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Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications

Gosecka

Gosecki

Jaworska‐Krych

2023

Adv Funct Materials

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Hydrogels, as 3D networks containing huge amount of water, display similarity to soft tissues, and thus they are of wide interest in tissue engineering. Hydrogels, due to biocompatibility and porous structure, are valuable therapeutic platforms for hydrophilic drugs. Over the last decade, there has been a strong emphasis on the development of hydrogel platforms with the ability to increase the solubility of hydrophobic drugs. However, the pronounced discrepancy between the hydrophilic character of hydrogels and the hydrophobic nature of numerous pharmacologically active compounds is problematic. In recent years, different strategies are applied using special polymer constructs or composite materials exploiting the advanced scientific knowledge in the area of polymer and lipid‐based nano‐ and microcarriers hydrophobization of the hydrogel turns out to be not only valuable in terms of achieving the ability to dissolve poorly soluble drugs in water, but also proves to be crucial in obtaining bioadhesion in wet conditions, but also, unexpected abnormal water swelling behavior, as well as in mechanical properties such as the dissipation mechanism and self‐healable hydrogel properties. This review is mainly focused on recent advances in the usage of hydrophobized hydrogels in biomedical applications.

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“…LCST of the PNIPAM polymer can be changed by copolymerization of the NIPAM monomer with various polymers such as poly (ethylene glycol), poly (acrylic acid) and cellulose, etc. [19][20][21] The copolymerization with hydrophobic polymers results a decrease in LCST of the PNIPAM. On the other hand, copolymerization with hydrophilic polymers leads to an increase in LCST due to the overall increase in hydrophilicity of the molecule and hence an increase in the hydrogen-bonding interactions between the polymer and water molecules.…”

Section: Introductionmentioning

confidence: 99%

P(NIPAM–co-MAM) Kopolimer Bitim İşlemi ile Sıcaklığa ve pH'a Duyarlı Akıllı Pamuklu Kumaşların Geliştirilmesi

Genç¹,

Aksoy²

2022

Tekstil Ve Konfeksiyon

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In this study, fabrication of smart polymer and cotton fabrics with temperature-and pH-responsive as well as antibacterial activity was aimed. For this aim, random poly(N-isopropylacrylamide-comethacrylamide) P(NIPAM-co-MAM) copolymers containing different ratio of NIPAM/MAM monomers were synthesized through free radical addition polymerization method via 2,2'-azobis (2 methylpropionamide) dihydrochloride as an initiator. Analysis results showed that the copolymers were synthesized successfully and their LCST values were in the range of 33°C to 41°C. A selected sample of the synthesized copolymers was applied to the cotton fabric via double-bath impregnation method and thermo-responsive wetting property of the fabric was examined via wetting time and water uptake tests, contact angle measurement. The test results indicated that hydrophilic character of the fabric changed to the hydrophobic character reversibly depending on change in temperature. Besides, the fabric exhibited pH-responsive water absorption ability. The fabric could manage water vapor permeability via changing its pore size as well as hydrophilic character depending on temperature. Besides, it was concluded that the fabric had strong antibacterial activity against S.aureus bacteria.

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Correction: Poly(N-isopropyl acrylamide)–poly(ethylene glycol)–poly(N-isopropyl acrylamide) as a thermoreversible gelator for topical administration

Abstract: Correction for ‘Poly(N-isopropyl acrylamide)–poly(ethylene glycol)–poly(N-isopropyl acrylamide) as a thermoreversible gelator for topical administration’ by P. Haddow et al., Mater. Adv., 2020, 1, 371–386, DOI: 10.1039/D0MA00080A.

Cited by 3 publications

References 0 publications

Injectable bottlebrush hydrogels with tissue-mimetic mechanical properties

Injectable bottlebrush hydrogels with tissue-mimetic mechanical properties

Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications

P(NIPAM–co-MAM) Kopolimer Bitim İşlemi ile Sıcaklığa ve pH'a Duyarlı Akıllı Pamuklu Kumaşların Geliştirilmesi

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