Correction: Relative Importance and Additive Effects of Maternal and Infant Risk Factors on Childhood Asthma

Wu, Pingsheng; Feldman, Amy S.; Rosas‐Salazar, Christian; James, Kristina; Escobar, Gabriel J.; Gebretsadik, Tebeb; Li, Sherian Xu; Carroll, Kecia N.; Walsh, Eileen M.; Mitchel, Edward F.; Das, Suman; Kumar, Rajesh; Yu, Chang; Dupont, William D.; Hartert, Tina V.

doi:10.1371/journal.pone.0156473

Cited by 6 publications

(2 citation statements)

References 1 publication

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“…Wu et al identified dose-dependent relationships between risk of childhood asthma and maternal urinary tract infections (UTIs) during pregnancy or infant antibiotic use during the first year of life 15 . The increase in risk is presumably due to changes in the abundance and diversity of the host's commensal microbes, as demonstrated by Penders et al, who reported that antibiotic use in infancy was associated with decreased abundance of Bifidobacteria and Bacteroides 16 .…”

Section: Microbial Exposurementioning

confidence: 99%

“…For instance, homes with dogs contain richer more diverse bacterial communities compared to homes without pets 33 . Differences in microbial exposure are seen with increasing family size 15 as well as with certain activities of the occupants, particularly farming. It has long been recognized that the prevalence of allergic disease amongst the children of farmers is lower than in non-farming families 28, 34-36 .…”

Section: Microbial Exposurementioning

confidence: 99%

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Environmental determinants of allergy and asthma in early life

Burbank¹,

Sood²,

Kesic

et al. 2017

Journal of Allergy and Clinical Immunology

252

177

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Allergic disease prevalence has significantly increased in recent decades. Primary prevention efforts are being guided by the study of the exposome, or collective environmental exposures beginning during the prenatal period, to identify modifiable factors that impact allergic disease risk. In this review, we explore the evidence supporting a relationship between key components of the external exposome in the prenatal and early-life periods and their impact on atopy development, focused on microbial, allergen, and air pollution exposures. The abundance and diversity of microbial exposures during the first months and years of life have been linked with risk of allergic sensitization and disease. Indoor environmental allergen exposure during early life may also impact disease development, depending on the allergen type, dose, and timing of exposure. Recent evidence supports the role of ambient air pollution in allergic disease inception. The lack of clarity in the literature surrounding the relationship between environment and atopy reflects the complex interplay between cumulative environmental factors and genetic susceptibility, such that no one factor dictates disease development in all individuals. Understanding the impact of the summation of environmental exposures throughout a child's development is needed to identify cost-effective interventions that reduce atopy risk in children.

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Section: Microbial Exposurementioning

confidence: 99%

Section: Microbial Exposurementioning

confidence: 99%

Environmental determinants of allergy and asthma in early life

Burbank¹,

Sood²,

Kesic

et al. 2017

Journal of Allergy and Clinical Immunology

252

177

View full text Add to dashboard Cite

show abstract

Probiotics for the prevention of pediatric antibiotic-associated diarrhea: Summary of a Cochrane review

Bethel¹

2019

EXPLORE

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Early-Life Antibiotic Exposure and Childhood Asthma Trajectories: A National Population-Based Birth Cohort

Wang

et al. 2023

Antibiotics

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Introduction: Early-life antibiotic exposure is common and impacts the development of the child’s microbiome and immune system. Information on the impacts of early-life antibiotics exposure on childhood asthma is lacking. Methods: This study examined associations between early-life (0–24 months) antibiotics exposure with childhood (6–15 years) asthma trajectories through the Australian Longitudinal Study of Australian Children (LSAC) and their linked data from the Pharmaceutical Benefits Scheme. Asthma phenotypes were derived by group-based trajectory modeling. Results: Of 5107 LSAC participants, 4318 were included in the final analyses (84.6% retention). Four asthma phenotypes were identified: Always-low-risk (79.0%), early-resolving asthma (7.1%), early-persistent asthma (7.9%), and late-onset asthma (6.0%). Any early-life antibiotic exposure increased risk 2.3-fold (95% CI: 1.47–3.67; p < 0.001) for early-persistent asthma among all children. In subgroup analyses, early-persistent asthma risk increased by 2.7-fold with any second-generation cephalosporin exposure, and by 2-fold with any β-lactam other than cephalosporin or macrolide exposure. Conclusion: We concluded that early-life antibiotic exposure is associated with an increased risk of early-persistent childhood asthma. This reinforces scrutiny of early-life antibiotic use, particularly for common viral infections where no antibiotics are required.

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Correction: Relative Importance and Additive Effects of Maternal and Infant Risk Factors on Childhood Asthma

Cited by 6 publications

References 1 publication

Environmental determinants of allergy and asthma in early life

Environmental determinants of allergy and asthma in early life

Probiotics for the prevention of pediatric antibiotic-associated diarrhea: Summary of a Cochrane review

Early-Life Antibiotic Exposure and Childhood Asthma Trajectories: A National Population-Based Birth Cohort

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