Correction: Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults

Diemert, David; Freire, Janaína de Moura; Valente, Vanderson; Fraga, Carlo Geraldo; Talles, Frederico; Grahek, Shannon; Campbell, Doreen; Jariwala, Amar; Periago, María Victoria; Enk, Martin Johannes; Gazzinelli, Maria Flávia; Bottazzi, María Elena; Hamilton, Robert H.; Brelsford, Jill; Yakovleva, Anna; Li, Guangzhao; Peng, Jianping; Corrêa-Oliveira, Rodrigo; Hotez, Peter J.; Bethony, Jeffrey M.

doi:10.1371/journal.pntd.0008670

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Structural and Functional Generalities Of Gstσ1

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2024

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“…Another, GST-1 from Necator americanus (Na-GST-1) belonging to the nu class, has also been identified as a vaccine candidate, and phase 1 clinical trials have been performed in Brazil, the United States, and Gabon [ 83 , 84 , 85 ].…”

Section: Structural and Functional Generalities Of Gstσmentioning

confidence: 99%

Sigma-Class Glutathione Transferases (GSTσ): A New Target with Potential for Helminth Control

Sánchez Pérez,

Zubillaga,

García-Gutiérrez

et al. 2024

TropicalMed

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Glutathione transferases (GSTs EC 2.5.1.18) are critical components of phase II metabolism, instrumental in xenobiotics’ metabolism. Their primary function involves conjugating glutathione to both endogenous and exogenous toxic compounds, which increases their solubility and enables their ejection from cells. They also play a role in the transport of non-substrate compounds and immunomodulation, aiding in parasite establishment within its host. The cytosolic GST subfamily is the most abundant and diverse in helminths, and sigma-class GST (GSTσ) belongs to it. This review focuses on three key functions of GSTσ: serving as a detoxifying agent that provides drug resistance, functioning as an immune system modulator through its involvement in prostaglandins synthesis, and acting as a vaccine antigen.

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Section: Structural and Functional Generalities Of Gstσmentioning

confidence: 99%