Correction: Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli

Norris, Callie A.; He, Mu; Kang, Liang‐I; Ding, Michael Q.; Radder, Josiah E.; Haynes, Meagan; Yang, Yu Hsuan Carol; Paranjpe, Shirish; Bowen, William C.; Orr, Anne; Michalopoulos, George K.; Stolz, Donna B.; Mars, Wendy M.

doi:10.1371/journal.pone.0224498

Cited by 3 publications

(1 citation statement)

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“…Induction of Ifng (IFNγ) also is associated with the proliferative phase of liver regeneration [ 61 ]. Similarly, the hepatocyte-expressed Il6 (IL-6) gene is rapidly induced by partial hepatectomy in rats [ 62 ]. The induction of Ifng and Il6 gene expression in male Klf9 KO livers and that of the Il6 gene in female Klf9 KO livers may indicate a normally suppressive effect of KLF9 on liver cell proliferation, an effect that might be predicted to lead to larger livers in Klf9 KO mice as was observed here.…”

Section: Discussionmentioning

confidence: 99%

Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet

Brown

Alhallak

Simmen

et al. 2022

Cancers

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Obesity, oxidative stress, and inflammation are risk factors for hepatocellular carcinoma (HCC). We examined, in mice, the effects of Krüppel-like factor 9 (KLF9) knockout on: adiposity, hepatic and systemic oxidative stress, and hepatic expression of pro-inflammatory and NOX/DUOX family genes, in a high-fat diet (HFD) context. Male and female Klf9+/+ (wild type, WT) and Klf9−/− (knockout, KO) mice were fed HFD (beginning at age 35 days) for 12 weeks, after which liver and adipose tissues were obtained, and serum adiponectin and leptin levels, liver fat content, and markers of oxidative stress evaluated. Klf9−/− mice of either sex did not exhibit significant alterations in weight gain, adipocyte size, adipokine levels, or liver fat content when compared to WT counterparts. However, Klf9−/− mice of both sexes had increased liver weight/size (hepatomegaly). This was accompanied by increased hepatic oxidative stress as indicated by decreased GSH/GSSG ratio and increased homocysteine, 3-nitrotyrosine, 3-chlorotyrosine, and 4HNE content. Decreased GSH to GSSG ratio and a trend toward increased homocysteine levels were observed in the corresponding Klf9−/− mouse serum. Gene expression analysis showed a heightened pro-inflammatory state in livers from Klf9−/− mice. KLF9 suppresses hepatic oxidative stress and inflammation, thus identifying potential mechanisms for KLF9 suppression of HCC and perhaps cancers of other tissues.

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Section: Discussionmentioning

confidence: 99%

Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet

Brown

Alhallak

Simmen

et al. 2022

Cancers

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Hepatocyte Transplantation Rebalances Cytokines for Hepatic Regeneration in Rats with Ataxia Telangiectasia Mutated Pathway-Related Acute Liver Failure

Jaber¹,

Sharma²,

Gupta³

2023

The American Journal of Pathology

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Bone-organ axes: bidirectional crosstalk

Deng,

Wang,

Wang

et al. 2024

Military Med Res

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In addition to its recognized role in providing structural support, bone plays a crucial role in maintaining the functionality and balance of various organs by secreting specific cytokines (also known as osteokines). This reciprocal influence extends to these organs modulating bone homeostasis and development, although this aspect has yet to be systematically reviewed. This review aims to elucidate this bidirectional crosstalk, with a particular focus on the role of osteokines. Additionally, it presents a unique compilation of evidence highlighting the critical function of extracellular vesicles (EVs) within bone-organ axes for the first time. Moreover, it explores the implications of this crosstalk for designing and implementing bone-on-chips and assembloids, underscoring the importance of comprehending these interactions for advancing physiologically relevant in vitro models. Consequently, this review establishes a robust theoretical foundation for preventing, diagnosing, and treating diseases related to the bone-organ axis from the perspective of cytokines, EVs, hormones, and metabolites.

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Correction: Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli

Cited by 3 publications

References 1 publication

Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet

Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet

Hepatocyte Transplantation Rebalances Cytokines for Hepatic Regeneration in Rats with Ataxia Telangiectasia Mutated Pathway-Related Acute Liver Failure

Bone-organ axes: bidirectional crosstalk

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