Correction: Testosterone deficiency reduces the effects of late cardiac remodeling after acute myocardial infarction in rats

Corrêa, Rafaela de Araujo Fernandes; Júnior, Rogério Faustino Ribeiro; Mendes, Sara Bianca Oliveira; Santos, Priscila Mendonça dos; Silva, Miracle Vitória Albino da; Silva, Daniel Ferron; Biral, Igor Peixoto; Batista, Priscila Rossi de; Vassallo, Dalton Valentim; Bittencourt, Athelson Stefanon; Stefanon, Ivanita; Fernandes, Aurélia Araújo

doi:10.1371/journal.pone.0226664

Cited by 6 publications

(1 citation statement)

References 2 publications

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“…Testosterone has detrimental effects on post-MI remodeling and promotes LV hypertrophy [80]. Rats undergoing orchiectomy and (1 week later) MI had less LV hypertrophy and better contractility after 8 weeks than rats with MI alone [81]. Testosterone also induces neutrophil infiltration and the expression of p38 and SPAN/JNK, which are associated with the inflammatory response in the heart [82,83], and to an increased risk of cardiac rupture [82].…”

Section: Histology and Molecular Biologymentioning

confidence: 99%

Sex-related differences in ventricular remodeling after myocardial infarction

Aimo

Panichella

Barison

et al. 2021

International Journal of Cardiology

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Section: Histology and Molecular Biologymentioning

confidence: 99%

Sex-related differences in ventricular remodeling after myocardial infarction

Aimo

Panichella

Barison

et al. 2021

International Journal of Cardiology

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Hypotestosteronemia is an important factor for the development of hypertension: elevated blood pressure in orchidectomized conscious rats is reversed by different androgens

2019

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Serum dihydrotestosterone levels are associated with adverse myocardial remodeling in patients with severe aortic valve stenosis before and after aortic valve replacement

Schafstedde

Nordmeyer

Berger

et al. 2022

American Journal of Physiology-Heart and Circulatory Physiology

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Aims Animal studies show a pivotal role of dihydrotestosterone (DHT) in pressure overload induced myocardial hypertrophy and dysfunction. The aim of our study was to evaluate the role of DHT levels and myocardial hypertrophy and myocardial protein expression in patients with severe aortic valve stenosis (AS). Methods and Results 43 patients (median age 68 (41-80) years) with severe AS and indication for surgical aortic valve replacement (SAVR) were prospectively enrolled. Cardiac magnetic resonance imaging including analysis of left ventricular muscle mass (LVM), fibrosis and function and laboratory tests including serum DHT levels were performed before and after SAVR. During SAVR left ventricular (LV) biopsies were performed for proteomic profiling. Serum DHT levels correlated positively with indexed LVM (LVMi, R=0.64, p<0.0001) and fibrosis (R=0.49, p=0.0065) and inversely with LV function (R=-0.42, p=0.005) in patients with severe AS. DHT levels were associated with higher abundance of the hypertrophy (moesin (R=0.52, p=0.0083)) and fibrosis (vimentin (R=0.41, p=0.039)) associated proteins from LV myocardial biopsies. Higher serum DHT levels preoperatively were associated with reduced LV function (ejection fraction: R=-0.34, p=0.035, circulatory efficiency: R=-0.46, p=0.012, global longitudinal strain: R=0.49, p=0.01) and increased fibrosis (R=0.55, p=0.0022) after SAVR. Conclusions Serum DHT levels were associated with adverse myocardial remodeling and higher abundance in hypertrophy and fibrosis associated proteins in patients with severe AS. DHT may be a target to prevent or attenuate adverse myocardial remodeling in patients with pressure overload due to AS.

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Correction: Testosterone deficiency reduces the effects of late cardiac remodeling after acute myocardial infarction in rats

Cited by 6 publications

References 2 publications

Sex-related differences in ventricular remodeling after myocardial infarction

Sex-related differences in ventricular remodeling after myocardial infarction

Hypotestosteronemia is an important factor for the development of hypertension: elevated blood pressure in orchidectomized conscious rats is reversed by different androgens

Serum dihydrotestosterone levels are associated with adverse myocardial remodeling in patients with severe aortic valve stenosis before and after aortic valve replacement

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