Correction: The Effect of Protandim® Supplementation on Athletic Performance and Oxidative Blood Markers in Runners

Ueberschlag, Seteena L.; Seay, James R.; Roberts, Alexandra H.; DeSpirito, Pamela C.; Stith, Jeremy M.; Folz, Rodney J.; Carter, Kathleen A.; Weiss, Edward P.; Zavorsky, Gerald S.

doi:10.1371/journal.pone.0241520

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…Moreover, the pharmaceutical activation of NRF2 is thought to be a promising strategy to protect the liver from damage caused by various chemicals [ 286 ]. Protandim, an herbal dietary supplement, induces the expression of the endogenous antioxidant enzymes SOD and catalase by activating NRF2 [ 287 , 288 ]. A newly synthesized drug, bardoxolone methyl, also attenuates chronic kidney diseases via its activation of NRF2 [ 289 ].…”

Section: Therapeutic Targets In Aldmentioning

confidence: 99%

Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease

Yan

et al. 2023

J Transl Med

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Alcoholism is a widespread and damaging behaviour of people throughout the world. Long-term alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading cause of chronic liver disease. Many metabolic enzymes, including alcohol dehydrogenases such as ADH, CYP2E1, and CATacetaldehyde dehydrogenases ALDHsand nonoxidative metabolizing enzymes such as SULT, UGT, and FAEES, are involved in the metabolism of ethanol, the main component in alcoholic beverages. Ethanol consumption changes the functional or expression profiles of various regulatory factors, such as kinases, transcription factors, and microRNAs. Therefore, the underlying mechanisms of ALD are complex, involving inflammation, mitochondrial damage, endoplasmic reticulum stress, nitrification, and oxidative stress. Moreover, recent evidence has demonstrated that the gut-liver axis plays a critical role in ALD pathogenesis. For example, ethanol damages the intestinal barrier, resulting in the release of endotoxins and alterations in intestinal flora content and bile acid metabolism. However, ALD therapies show low effectiveness. Therefore, this review summarizes ethanol metabolism pathways and highly influential pathogenic mechanisms and regulatory factors involved in ALD pathology with the aim of new therapeutic insights.

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Section: Therapeutic Targets In Aldmentioning

confidence: 99%

Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease

Yan

et al. 2023

J Transl Med

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Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu

Garay¹

2021

Expert Opinion on Investigational Drugs

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Correction: The Effect of Protandim® Supplementation on Athletic Performance and Oxidative Blood Markers in Runners

Cited by 2 publications

References 2 publications

Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease

Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease

Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu

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