Correction: TLR4 downregulation by the RNA-binding protein PUM1 alleviates cellular aging and osteoarthritis

Yoon, Dong Suk; Lee, Kyoung-Mi; Choi, Yoorim; Ko, Eun A.; Lee, Na-Hyun; Cho, Sehee; Park, Kwang Hwan; Lee, Jung Hwan; Kim, Hae‐Won; Lee, Jin Woo

doi:10.1038/s41418-022-00945-w

Cited by 5 publications

(4 citation statements)

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“… 3 , 27 , 28 TLR4 downregulation by PUM1 alleviates cellular senescence in human mesenchymal stem cells. 29 The role of TLR4 as a molecular initiator of cellular senescence is consistent with our results in hDPCs but inconsistent with the inhibitory effects of TLR4 on the senescence of other cell types, including skin fibroblasts and endothelial cells. 30 , 31 The reason for this discrepancy is unclear, but may be related to the cell type- and context-dependent effects of TLR4 signaling.…”

Section: Discussionsupporting

confidence: 46%

“…Substantial progress has been made in understanding of the role of TLR4 in senescence/aging. 3 , 27 , 28 , 29 For example, the activation of TLR4 by LPS or S100A9 accelerates senescence of placental mesenchymal stem cells, human dental pulp stem cells, or bone marrow stromal cells. 3 , 27 , 28 TLR4 downregulation by PUM1 alleviates cellular senescence in human mesenchymal stem cells.…”

Section: Discussionmentioning

confidence: 99%

“…TLR4 is implicated in the pathogenesis of pulpitis, 36 , 37 , 38 and evidence indicates its important role in cellular senescence/aging. 29 , 39 , 40 . Although many studies have shown that visfatin-induced inflammatory responses mediate the TLR4/NF-κB pathway, no previous reports had shown whether TLR4 acts on visfatin-induced cellular senescence.…”

Section: Discussionmentioning

confidence: 99%

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Involvement of the visfatin/toll-like receptor 4 signaling axis in human dental pulp cell senescence: Protection via toll-like receptor 4 blockade

Park

Jang

et al. 2023

Journal of Dental Sciences

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Section: Discussionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Involvement of the visfatin/toll-like receptor 4 signaling axis in human dental pulp cell senescence: Protection via toll-like receptor 4 blockade

Park

Jang

et al. 2023

Journal of Dental Sciences

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“…The RBP PUM1 binds the 3´-untranslated region of Toll-like receptor 4 (TLR4) to clear TLR4 mRNA translation and monitor the activity of nuclear factor-κB (NF-κB), a master regulator of the aging process in human mesenchymal stem cells. PUM1 also protects human chondrocytes to avoid chondrogenic phenotype loss and alleviates cellular osteoarthritis [ 29 ]. The loss of functional RBP muscle blind-like protein 1 (MBNL1) in response to its nuclear seclusion by mutant transcripts containing pathogenic expanded CUG repeats (CUGexp) leads to Myotonic dystrophy type 1 [ 30 ].…”

Section: General Roles Attributed To Rna-binding Proteinsmentioning

confidence: 99%

Roles of RNA-binding proteins in neurological disorders, COVID-19, and cancer

2022

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RNA-binding proteins (RBPs) have emerged as important players in multiple biological processes including transcription regulation, splicing, R-loop homeostasis, DNA rearrangement, miRNA function, biogenesis, and ribosome biogenesis. A large number of RBPs had already been identified by different approaches in various organisms and exhibited regulatory functions on RNAs’ fate. RBPs can either directly or indirectly interact with their target RNAs or mRNAs to assume a key biological function whose outcome may trigger disease or normal biological events. They also exert distinct functions related to their canonical and non-canonical forms. This review summarizes the current understanding of a wide range of RBPs’ functions and highlights their emerging roles in the regulation of diverse pathways, different physiological processes, and their molecular links with diseases. Various types of diseases, encompassing colorectal carcinoma, non-small cell lung carcinoma, amyotrophic lateral sclerosis, and Severe acute respiratory syndrome coronavirus 2, aberrantly express RBPs. We also highlight some recent advances in the field that could prompt the development of RBPs-based therapeutic interventions.

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Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy

Lin,

Huang,

Jiao

et al. 2024

Bioengineering & Transla Med

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Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a huge burden on the health care system worldwide. Although traditional therapy and targeted cartilage cell therapy have made significant progress in the treatment of OA and cartilage regeneration, there are still many problems. Mesenchymal stem cells from various tissues are the most studied cell type and have been used in preclinical and clinical studies of OA, because they are more widely available, have a greater capacity for in vitro expansion, and have anti‐inflammatory and immunomodulatory properties compared to autologous chondrocytes. This article will systematically review the latest developments in these areas. It may provide new insights for improving OA and cartilage regeneration.

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Correction: TLR4 downregulation by the RNA-binding protein PUM1 alleviates cellular aging and osteoarthritis

Cited by 5 publications

References 0 publications

Involvement of the visfatin/toll-like receptor 4 signaling axis in human dental pulp cell senescence: Protection via toll-like receptor 4 blockade

Involvement of the visfatin/toll-like receptor 4 signaling axis in human dental pulp cell senescence: Protection via toll-like receptor 4 blockade

Roles of RNA-binding proteins in neurological disorders, COVID-19, and cancer

Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy

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