Correction to: A non-canonical Δ9-desaturase synthesizing palmitoleic acid identified in the thraustochytrid Aurantiochytrium sp. T66

Rau, E-Ming; Aasen, Inga Marie; Ertesvåg, Helga

doi:10.1007/s00253-021-11562-x

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“…Rau and his colleague also find that the Δ9-desaturase from Aurantiochytrium sp . T66 could accept palmitic acid and stearic acid as substrates ( 59 ). The reasonable explanation for substrate preference was also given out through homology modeling and docking in the last paragraph.…”

Section: Vital Desaturase In ω-6 and ω-3 Pathwaymentioning

confidence: 99%

Key Enzymes in Fatty Acid Synthesis Pathway for Bioactive Lipids Biosynthesis

et al. 2022

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Dietary bioactive lipids, one of the three primary nutrients, is not only essential for growth and provides nutrients and energy for life's activities but can also help to guard against disease, such as Alzheimer's and cardiovascular diseases, which further strengthen the immune system and maintain many body functions. Many microorganisms, such as yeast, algae, and marine fungi, have been widely developed for dietary bioactive lipids production. These biosynthetic processes were not limited by the climate and ground, which are also responsible for superiority of shorter periods and high conversion rate. However, the production process was also exposed to the challenges of low stability, concentration, and productivity, which was derived from the limited knowledge about the critical enzyme in the metabolic pathway. Fortunately, the development of enzymatic research methods provides powerful tools to understand the catalytic process, including site-specific mutagenesis, protein dynamic simulation, and metabolic engineering technology. Thus, we review the characteristics of critical desaturase and elongase involved in the fatty acids' synthesis metabolic pathway, which aims to not only provide extensive data for enzyme rational design and modification but also provides a more profound and comprehensive understanding of the dietary bioactive lipids' synthetic process.

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Section: Vital Desaturase In ω-6 and ω-3 Pathwaymentioning

confidence: 99%