Correction to: Antiinflammatory constituents of Atractylodes chinensis rhizome improve glomerular lesions in immunoglobulin A nephropathy model mice

Ishii, Toshinari; Okuyama, Tetsuya; Noguchi, Nao; Nishidono, Yuto; Okumura, Tadayoshi; Kaibori, Masaki; Tanaka, Ken; Terabayashi, Susumu; Ikeya, Yukinobu; Nishizawa, Mikio

doi:10.1007/s11418-020-01405-w

Cited by 7 publications

(4 citation statements)

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“…Furthermore, ATL-III can reduce chronic kidney disease-induced inflammation and muscle atrophy by inhibiting the PI3K-Akt pathway (Wang et al, 2019). And then, ATL-III also reduces the production of proinflammatory mediators NO, reduces the levels of TNF and IL, and then relieves the damage to renal cells (Ishii et al, 2020). Therefore, rhizoma Atractylodis has been used for clinical prevention and treatment of renal injury after Covid-19 infection (He et al, 2020).…”

Section: Atractylodesmentioning

confidence: 99%

Research on Vietnamese Medicinal Plants With Potential in the Treatment of Covid-19 Disease

Le¹

2022

Khoa học và Phát triển

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Natural products have been considered the primary source of healthcare among the majority of the world’s population. In the therapeutic management of Covid-19, products of natural origin are a promising and potential medicinal source to treat this disease. Our research methodology is based on a review of recent articles reporting on the effect of medicinal plants on Covid-19. In this review, literature searches on medicinal plants which used to treat and prevent Covid-19 disease were conducted. From this research, several medicinal plants have received much research attention such as Astragalus mongholicus Bunge; Astragalus membranaceus (Fisch.) Bunge; Atractylodes lancea (Thunb.) DC.; Atractylodes chinensis (DC.) Koidz.; Atractylodes japonica Koidz.; and Atractylodes macrocephala Koidz.; Andrographis paniculata; Lonicera japonica; Scutellaria baicalensis Georgi. However, the definitive roles of these medicinal plants in cytokine storms and post-infection complications still need further investigation. And then, quality control and standardisation of medicinal plants-based products also need to be emphasized. Further investigations on differential effects as well as the quality and safety of herbal medicines should be required to ascertain their role in Covid-19 therapeutic management. Furthermore, herbal mixtures, medicinal plants, natural products, or their combination with possible anti-SARS-CoV-2 effects may hold promise and effectiveness in preventive and therapeutic support for Covid-19.

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Section: Atractylodesmentioning

confidence: 99%

Research on Vietnamese Medicinal Plants With Potential in the Treatment of Covid-19 Disease

Le¹

2022

Khoa học và Phát triển

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“…Paeoniflorin [4] and isoliquiritigenin [5] are widely known to have hepatoprotective potential. Furthermore, glycyrrhizin, another component of Glycyrrhizae Radix [6], and a certain fraction of Sojyutu extract [7] have been reported…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective and anti-inflammatory profile of sokeikakketsuto and makyoyokukanto in primary cultured rat hepatocytes

Sakaguchi

Okuyama

Kotsuka

et al. 2022

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Background: Sokeikakketsuto (SOK) is a Kampo medicine that can mitigate several types of pain, including arthralgia, neuralgia, low back pain, and myalgia, which may be introduced for the treatment of neuropathic pain in anti-cancer therapy. Considering that several Kampo medicines are known to have hepatoprotective and anti-inflammatory effects, we investigated the pharmacological mechanism of SOK in hepatocytes. Additionally, we examined another Kampo medicine, makyoyokukanto (MAK), as a reference as it has been reported to have similar efficacy for neuropathic pain.Methods: SOK or MAK was incubated with rat primary cultured hepatocytes treated with interleukin (IL)-1β. The induction of inducible nitric oxide synthase (iNOS), nitric oxide (NO) production, iNOS signaling pathways, and the expression of other inflammatory mediators was investigated.Results: IL-1β activated iNOS induction, followed by NO production. SOK and MAK reduced the expression of iNOS mRNA and its protein and decreased NO production. SOK and MAK also decreased the levels of tumor necrosis factor (TNF)-α and increased the levels of IL-6 and IL-1β. Transfection experiments with iNOS promoter-luciferase constructs revealed that MAK reduced iNOS mRNA synthesis and stability; however, SOK only reduced mRNA synthesis. Both medicines suppressed the activation of nuclear factor (NF)-κB but did not block the upregulation of type I IL-1 receptor in two essential signaling pathways.Conclusions: SOK and MAK could prevent NO production by inhibiting iNOS gene expression, partly through NF-κB activation, in inflamed hepatocytes. However, both medicines may have different mechanisms of action in the treatment of injured organs.

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“…The main bioactive compounds in A. chinensis rhizome are used to treat digestive disorders, rheumatic diseases and night blindness [ 6 ]. Modern pharmacological studies have demonstrated that A. chinensis also has anti-inflammatory, anti-bacterial [ 11 , 20 ] and antitumor [ 13 ] properties. Although the sesquiterpenoid components of A. chinensis rhizome have important pharmacological activities, the molecular mechanisms underlying accumulation of bioactive sesquiterpenoids are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Comparative transcriptome analysis reveals sesquiterpenoid biosynthesis among 1-, 2- and 3-year old Atractylodes chinensis

et al. 2021

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Background Atractylodes chinensis (DC.) Koidz is a well-known medicinal plant containing the major bioactive compound, atractylodin, a sesquiterpenoid. High-performance liquid chromatography (HPLC) analysis demonstrated that atractylodin was most abundant in 3-year old A. chinensis rhizome, compared with those from 1- and 2-year old rhizomes, however, the molecular mechanisms underlying accumulation of atractylodin in rhizomes are poorly understood. Results In this study, we characterized the transcriptomes from rhizomes of 1-, 2- and 3-year old (Y1, Y2 and Y3, respectively) A. chinensis, to identify differentially expressed genes (DEGs). We identified 240, 169 and 131 unigenes encoding the enzyme genes in the mevalonate (MVA), methylerythritol phosphate (MEP), sesquiterpenoid and triterpenoid biosynthetic pathways, respectively. To confirm the reliability of the RNA sequencing analysis, eleven key gene encoding factors involved in the sesquiterpenoid and triterpenoid biosynthetic pathway, as well as in pigment, amino acid, hormone and transcription factor functions, were selected for quantitative real time PCR (qRT-PCR) analysis. The results demonstrated similar expression patterns to those determined by RNA sequencing, with a Pearson’s correlation coefficient of 0.9 between qRT-PCR and RNA-seq data. Differential gene expression analysis of rhizomes from different ages revealed 52 genes related to sesquiterpenoid and triterpenoid biosynthesis. Among these, seven DEGs were identified in Y1 vs Y2, Y1 vs Y3 and Y2 vs Y3, of which five encoded four key enzymes, squalene/phytoene synthase (SS), squalene-hopene cyclase (SHC), squalene epoxidase (SE) and dammarenediol II synthase (DS). These four enzymes directly related to squalene biosynthesis and subsequent catalytic action. To validate the result of these seven DEGs, qRT-PCR was performed and indicated most of them displayed lower relative expression in 3-year old rhizome, similar to transcriptomic analysis. Conclusion The enzymes SS, SHC, SE and DS down-regulated expression in 3-year old rhizome. This data corresponded to the higher content of sesquiterpenoid in 3-year old rhizome, and confirmed by qRT-PCR. The results of comparative transcriptome analysis and identified key enzyme genes laid a solid foundation for investigation of production sesquiterpenoid in A. chinensis.

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Correction to: Antiinflammatory constituents of Atractylodes chinensis rhizome improve glomerular lesions in immunoglobulin A nephropathy model mice

Cited by 7 publications

References 0 publications

Research on Vietnamese Medicinal Plants With Potential in the Treatment of Covid-19 Disease

Research on Vietnamese Medicinal Plants With Potential in the Treatment of Covid-19 Disease

Hepatoprotective and anti-inflammatory profile of sokeikakketsuto and makyoyokukanto in primary cultured rat hepatocytes

Comparative transcriptome analysis reveals sesquiterpenoid biosynthesis among 1-, 2- and 3-year old Atractylodes chinensis

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